دورية أكاديمية
أعرض في EDS

Potential diagnostic biomarkers for immunogenic cell death in elderly female patients with ischemic stroke: identification and analysis.

التفاصيل البيبلوغرافية
العنوان: Potential diagnostic biomarkers for immunogenic cell death in elderly female patients with ischemic stroke: identification and analysis.
المؤلفون: Qin L; School of Nursing, Hunan University of Chinese Medicine, Changsha, 410208, Hunan, People's Republic of China.; Key Laboratory of Hunan Province for Prevention and Treatment of Integrated Traditional Chinese and Western Medicine On Cardiocerebral Diseases, Hunan University of Chinese Medicine, Changsha, 410208, Hunan, People's Republic of China., Li S; Key Laboratory of Hunan Province for Prevention and Treatment of Integrated Traditional Chinese and Western Medicine On Cardiocerebral Diseases, Hunan University of Chinese Medicine, Changsha, 410208, Hunan, People's Republic of China., Cao X; School of Nursing, Hunan University of Chinese Medicine, Changsha, 410208, Hunan, People's Republic of China., Huang T; School of Nursing, Hunan University of Chinese Medicine, Changsha, 410208, Hunan, People's Republic of China., Liu Y; School of Nursing, Hunan University of Chinese Medicine, Changsha, 410208, Hunan, People's Republic of China., Chen O; School of Nursing, Hunan University of Chinese Medicine, Changsha, 410208, Hunan, People's Republic of China. 003861@hnucm.edu.cn.
المصدر: Scientific reports [Sci Rep] 2024 Jun 24; Vol. 14 (1), pp. 14553. Date of Electronic Publication: 2024 Jun 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Ischemic Stroke*/genetics , Ischemic Stroke*/immunology , Ischemic Stroke*/diagnosis , Immunogenic Cell Death* , Chemokine CCL20*/genetics , Chemokine CCL20*/metabolism, Humans ; Female ; Aged ; Biomarkers ; Nomograms ; Gene Regulatory Networks ; Machine Learning ; Gene Expression Profiling ; ROC Curve ; Aged, 80 and over
مستخلص: Ischemic stroke (IS) is of increasing concern given the aging population and prevalence of unhealthy lifestyles, with older females exhibiting higher susceptibility. This study aimed to identify practical diagnostic markers, develop a diagnostic model for immunogenic cell death (ICD)-associated IS, and investigate alterations in the immune environment caused by hub genes. Differentially expressed genes associated with ICD in IS were identified based on weighted gene co-expression network analysis and the identification of significant modules. Subsequently, machine learning algorithms were employed to screened hub genes, which were further assessed using Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and Gene Set Enrichment Analysis. A nomogram mode lwas then constructed for IS diagnosis, and its diagnostic value was assessed using a receiver operating characteristic curve. Finally, alterations in immune cell infiltration were assessed within patients with IS, and the pan-cancer expression patterns of hub genes were evaluated. Three hub genes associated with ICD (PDK4, CCL20, and FBL) were identified. The corresponding nomogram model for IS diagnosis could effectively identify older female patients with IS (area under the curve (AUC) = 0.9555). Overall, the three hub genes exhibit good diagnostic value (AUC > 0.8). CCL20 and FBL are significantly associated with the extent of immune cells infiltration. Moreover, a strong link exists between hub gene expression and pan-cancer prognosis. Cumulatively, these results indicate that ICD-related hub genes critically influence IS progression in older females, presenting novel diagnostic and therapeutic targets for personalized treatment.
(© 2024. The Author(s).)
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معلومات مُعتمدة: 82374437 the National Natural Science Foundation of China; 81904180 the National Natural Science Foundation of China; grant number 22JBZ041 Disciplinary Reveal System project of Hunan University of Chinese Medicine; grant number B202319018677 Scientific Research Project of Hunan Provincial Health Commission; grant number A2024001 Project of Hunan Provincial Administration of Traditional Chinese Medicine; grant number 2023JJ50035 Hunan Provincial Natural Science Foundation of China; grant number 2024JJ8124 Hunan Provincial Natural Science Foundation of China
فهرسة مساهمة: Keywords: Diagnostic biomarkers; Differentially expressed genes; Immunogenic cell death; Ischemic stroke; Older female patients
المشرفين على المادة: 0 (Chemokine CCL20)
0 (Biomarkers)
0 (CCL20 protein, human)
تواريخ الأحداث: Date Created: 20240624 Date Completed: 20240624 Latest Revision: 20240627
رمز التحديث: 20240627
مُعرف محوري في PubMed: PMC11196739
DOI: 10.1038/s41598-024-65390-w
PMID: 38914792
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-024-65390-w