دورية أكاديمية
أعرض في EDS

Bacterial profile and antibiotic susceptibility patterns in patients with secondary peritonitis: a cross-sectional study in Uganda.

التفاصيل البيبلوغرافية
العنوان: Bacterial profile and antibiotic susceptibility patterns in patients with secondary peritonitis: a cross-sectional study in Uganda.
المؤلفون: Godefroy NB; Department of Surgery, Faculty of Clinical Medicine and Dentistry, Kampala International University Western Campus, Ishaka-Bushenyi, Uganda. nyenkegodefroy@yahoo.fr., Muhumuza J; Department of Surgery, Faculty of Clinical Medicine and Dentistry, Kampala International University Western Campus, Ishaka-Bushenyi, Uganda. joshuablessed7@gmail.com., Molen SF; Department of Surgery, Faculty of Clinical Medicine and Dentistry, Kampala International University Western Campus, Ishaka-Bushenyi, Uganda., Waziri MA; Department of Surgery, Faculty of Clinical Medicine and Dentistry, Kampala International University Western Campus, Ishaka-Bushenyi, Uganda.; Department of General Surgery, State Specialist Hospital, Borno State, Shehu Laminu Way, P.M.B, Maiduguri, 1014, Nigeria., Kagenderezo BP; Department of Surgery, Faculty of Clinical Medicine and Dentistry, Kampala International University Western Campus, Ishaka-Bushenyi, Uganda., Vahwere BM; Department of Surgery, Faculty of Clinical Medicine and Dentistry, Kampala International University Western Campus, Ishaka-Bushenyi, Uganda., Sikakulya FK; Department of Surgery, Faculty of Clinical Medicine and Dentistry, Kampala International University Western Campus, Ishaka-Bushenyi, Uganda., Mauricio W; Department of Surgery, Faculty of Clinical Medicine and Dentistry, Kampala International University Western Campus, Ishaka-Bushenyi, Uganda., Wandabwa J; Department of Surgery, Hoima Regional Referral Hospital, Hoima, Uganda., Francois BK; Department of Internal Medicine, Faculty of Clinical Medicine and Dentistry, Kampala International University Western Campus, Ishaka-Bushenyi, Uganda., Agwu E; Department of Microbiology, Faculty of Clinical Medicine and Dentistry, Kampala International University Western Campus, Ishaka-Bushenyi, Uganda., Okedi XF; Department of Surgery, Faculty of Clinical Medicine and Dentistry, Kampala International University Western Campus, Ishaka-Bushenyi, Uganda.
المصدر: Perioperative medicine (London, England) [Perioper Med (Lond)] 2024 Jun 24; Vol. 13 (1), pp. 62. Date of Electronic Publication: 2024 Jun 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101609072 Publication Model: Electronic Cited Medium: Print ISSN: 2047-0525 (Print) Linking ISSN: 20470525 NLM ISO Abbreviation: Perioper Med (Lond) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2012]-
مستخلص: Introduction: Secondary peritonitis is the second leading cause of sepsis worldwide. Drug resistance to peritoneal cavity bacterial infection remains a public health threat, especially in resource-limited settings in Africa, including Uganda. This study aimed to determine the antibacterial susceptibility patterns and factors associated with secondary peritonitis among patients with acute abdomen who underwent surgery at a Regional Referral Hospital in Uganda.
Methods: This was a cross-sectional study conducted at Hoima Regional Referral Hospital (HRRH) that enrolled 126 patients with acute abdomen. Clinical samples were aseptically collected at laparotomy from patients with secondary peritonitis for culture and sensitivity using standard Microbiological methods. Binary logistic regression was used to identify factors associated with secondary peritonitis among patients with acute abdomen.
Results: The majority of the patients were males (61.9%) with a mean age of 37.9(SD ± 21.8). Secondary peritonitis was found in 57(45.2%) of the patients. Gram-negative bacteria were the most commonly isolated organisms with Escherichia coli (35.8%) and Klebsiella spp (17.0%) predominating. Imipenem 88.8%(8/9), Amikacin 88.8%(8/9), Ciprofloxacin 44.4%(4/9) and Gentamicin 44.4%(4/9) demonstrated sensitivity to the different isolated organisms at varying degrees. Being a male (AOR = 3.658; 95% CI = 1.570-8.519, p = 0.003) and presenting 3 days after onset of symptoms (AOR = 2.957; 95% CI = 1.232-7.099, p = 0.015) were independently associated with secondary peritonitis.
Conclusion: Imipenem, Amikacin, Ciprofloxacin, and Gentamicin should be considered for empirical therapy in cases of secondary peritonitis. Patients, more especially males with abdominal pain should be encouraged to present early to the hospital to minimize progression to secondary peritonitis.
(© 2024. The Author(s).)
References: Am J Trop Med Hyg. 2020 Jun;102(6):1296-1305. (PMID: 32228795)
World J Emerg Surg. 2012 Mar 08;7:4. (PMID: 22401289)
Pain. 1999 Dec;83(3):419-425. (PMID: 10568849)
J Med Life. 2008 Jan-Mar;1(1):66-71. (PMID: 20108482)
Int J Surg Protoc. 2023 Feb 06;27(1):9-17. (PMID: 36818423)
Cureus. 2021 May 28;13(5):e15301. (PMID: 34221758)
Surg Infect (Larchmt). 2018 May/Jun;19(4):382-387. (PMID: 29621001)
BMJ Open. 2020 Jan 8;10(1):e034326. (PMID: 31919127)
J Clin Pathol. 1982 May;35(5):555-60. (PMID: 7085900)
Int J Hepatol. 2014;2014:917856. (PMID: 24778884)
World J Emerg Surg. 2016 Jul 15;11:33. (PMID: 27429642)
Infect Drug Resist. 2021 Oct 05;14:4107-4117. (PMID: 34675556)
Ther Adv Infect Dis. 2019 Jul 31;6:2049936119865796. (PMID: 31391942)
Trop Doct. 2020 Jan;50(1):15-19. (PMID: 31739759)
BMC Emerg Med. 2016 Oct 21;16(1):41. (PMID: 27769180)
Niger J Clin Pract. 2006 Dec;9(2):169-73. (PMID: 17319352)
World J Emerg Surg. 2015 Oct 06;10:47. (PMID: 26448784)
Scand J Surg. 2021 Jun;110(2):139-149. (PMID: 33406974)
Surgery. 2016 Dec;160(6):1645-1656. (PMID: 27712880)
Afr J Infect Dis. 2014;8(1):9-13. (PMID: 24653811)
فهرسة مساهمة: Keywords: Bacteria isolates; Risk factors; Secondary peritonitis; Susceptibility
تواريخ الأحداث: Date Created: 20240624 Latest Revision: 20240627
رمز التحديث: 20240627
مُعرف محوري في PubMed: PMC11197276
DOI: 10.1186/s13741-024-00425-4
PMID: 38915124
قاعدة البيانات: MEDLINE
الوصف
تدمد:2047-0525
DOI:10.1186/s13741-024-00425-4