دورية أكاديمية
أعرض في EDS

Converging cytokine and metabolite networks shape asymmetric T cell fate at the term human maternal-fetal interface.

التفاصيل البيبلوغرافية
العنوان: Converging cytokine and metabolite networks shape asymmetric T cell fate at the term human maternal-fetal interface.
المؤلفون: Maurice NJ; Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA.; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA., Erickson JR; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA., DeJong CS; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA., Mair F; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA., Taber AK; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA., Frutoso M; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA., Islas LV; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA., Vigil AB; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA., Lawler RL; Immune Monitoring Core, Fred Hutchinson Cancer Center, Seattle, WA., McElrath MJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA.; Department of Medicine, University of Washington, Seattle, WA., Newell EW; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA., Sullivan LB; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA., Shree R; Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Washington, Seattle, WA., McCartney SA; Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Washington, Seattle, WA.
المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 12. Date of Electronic Publication: 2024 Jun 12.
نوع المنشور: Journal Article; Preprint
اللغة: English
بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
مستخلص: Placentation presents immune conflict between mother and fetus, yet in normal pregnancy maternal immunity against infection is maintained without expense to fetal tolerance. This is believed to result from adaptations at the maternal-fetal interface (MFI) which affect T cell programming, but the identities (i.e., memory subsets and antigenic specificities) of T cells and the signals that mediate T cell fates and functions at the MFI remain poorly understood. We found intact recruitment programs as well as pro-inflammatory cytokine networks that can act on maternal T cells in an antigen-independent manner. These inflammatory signals elicit T cell expression of co-stimulatory receptors necessary for tissue retention, which can be engaged by local macrophages. Although pro-inflammatory molecules elicit T cell effector functions, we show that additional cytokine (TGF-β1) and metabolite (kynurenine) networks may converge to tune T cell function to those of sentinels. Together, we demonstrate an additional facet of fetal tolerance, wherein T cells are broadly recruited and restrained in an antigen-independent, cytokine/metabolite-dependent manner. These mechanisms provide insight into antigen-nonspecific T cell regulation, especially in tissue microenvironments where they are enriched.
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معلومات مُعتمدة: K12 HD000849 United States HD NICHD NIH HHS; R21 AI144677 United States AI NIAID NIH HHS; F31 HD098769 United States HD NICHD NIH HHS; R01 CA264646 United States CA NCI NIH HHS; F99 CA245735 United States CA NCI NIH HHS; TL1 TR002318 United States TR NCATS NIH HHS
تواريخ الأحداث: Date Created: 20240625 Latest Revision: 20240703
رمز التحديث: 20240703
مُعرف محوري في PubMed: PMC11195144
DOI: 10.1101/2024.06.10.598377
PMID: 38915597
قاعدة البيانات: MEDLINE
الوصف
تدمد:2692-8205
DOI:10.1101/2024.06.10.598377