دورية أكاديمية
أعرض في EDS

Is opium use related to the increased risk of oral cavity cancers? A case-control study in Iran.

التفاصيل البيبلوغرافية
العنوان: Is opium use related to the increased risk of oral cavity cancers? A case-control study in Iran.
المؤلفون: Naghibzadeh-Tahami A; Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran., Karamoozian A; Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran., Iranpour A; HIV/STI Surveillance Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran., Mirshekarpour H; Clinical Research Unit, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran., Zahedi MJ; Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran., Enhesari A; Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran., Haghdoost AA; Social Determinants of Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran. Electronic address: ahaghdoost@gmail.com.
المصدر: Cancer epidemiology [Cancer Epidemiol] 2024 Aug; Vol. 91, pp. 102602. Date of Electronic Publication: 2024 Jun 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101508793 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1877-783X (Electronic) Linking ISSN: 18777821 NLM ISO Abbreviation: Cancer Epidemiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam : Elsevier
مواضيع طبية MeSH: Mouth Neoplasms*/epidemiology , Mouth Neoplasms*/etiology , Opium*/adverse effects, Humans ; Case-Control Studies ; Male ; Female ; Iran/epidemiology ; Middle Aged ; Risk Factors ; Opium Dependence/epidemiology ; Adult ; Aged ; Incidence
مستخلص: Background: Oral cavity cancers (OCCs) are the sixth most prevalent cancers in the world. There are strong evidences showing the risk of the cigarette smoking, alcohol use, poor oral hygiene and some types of diets in OCCs; however, few studies explored the relationship between opium and its derivatives (O&D) use and OCCs incidence. The aim of this study was to investigate the relationship between consumption of O&D and the incidence of OCCs.
Methods: In a case-control; 133 patients with OCCs and 266 healthy controls matched by age, sex, and place of residence were included. Data, including cigarette smoking, O&D, alcohol and others tobacco (Nass, pipe and hookah) use and diet, were collected using a structured questionnaire. The relation between the use of O&D and OCCs was evaluated using conditional logistic regression.
Results: Opium ever-use was associated with an increased risk of OCCs (Adjusted Odds Ratio (AOR) =2.36, 95 % CI: 1.16-4.78). A dose-response relation was observed between the amount of daily O&D use and OCCs; and the relation was stronger in high users (AOR for low users = 1.38, 95 %CI: 0.58-3.24 and AOR for high users = 4.85, 95 % CI:1.79-13.11). Those who used opium for more than 18 years were highly at risk of OCCs (AOR= 5.04, 95 % CI, 2.00-12.68). Also, OCCs was higher among subjects starting the use of O&D at younger ages (≤ 50 years old vs never users AOR = 3.32, 95 % CI: 1.19-9.23). The smoking method of consuming O&D increased the odds of getting OCCs more than twice (AOR= 2.02, 95 % CI, 1.03-3.94), and using both smoking and oral consumption simultaneously, increased the odds of getting OCCs more than 8 times (AOR= 8.57, 95 % CI, 1.68-43.70). Also, the use of other tobacco products (Nass, pipe and hookah) increases the odds of getting OCCs by 4 times (AOR= 3.90, 95 % CI, 1.12-13.57) CONCLUSIONS: The results showed that opium use is probably a dose related risk factor for oral cavity cancers. Therefore, it is necessary to implement preventive policies to control the use of opioids.
Competing Interests: Declaration of Competing Interest The authors declare that they have no Conflict of interests
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: Case-control; Opioids; oral cavity neoplasm
المشرفين على المادة: 8008-60-4 (Opium)
تواريخ الأحداث: Date Created: 20240625 Date Completed: 20240714 Latest Revision: 20240714
رمز التحديث: 20240715
DOI: 10.1016/j.canep.2024.102602
PMID: 38917615
قاعدة البيانات: MEDLINE
الوصف
تدمد:1877-783X
DOI:10.1016/j.canep.2024.102602