دورية أكاديمية
أعرض في EDS

Spatial control of perilacunar canalicular remodeling during lactation.

التفاصيل البيبلوغرافية
العنوان: Spatial control of perilacunar canalicular remodeling during lactation.
المؤلفون: Sieverts M; Department of Mechanical Engineering, University of Utah, Salt Lake City, UT, 84112, USA., Yee C; Department of Orthopedic Surgery, University of California, San Francisco, CA, 94131, USA., Nemani M; Department of Orthopedic Surgery, University of California, San Francisco, CA, 94131, USA., Parkinson DY; Advanced Light Source, Lawrence Berkeley Laboratory, Berkeley, CA, 94720, USA., Alliston T; Department of Orthopedic Surgery, University of California, San Francisco, CA, 94131, USA., Acevedo C; Department of Mechanical Engineering, University of Utah, Salt Lake City, UT, 84112, USA. claire.acevedo@gmail.com.; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, 84112, USA. claire.acevedo@gmail.com.; Department of Mechanical and Aerospace Engineering, University of California San Diego, San Diego, CA, 92161, USA. claire.acevedo@gmail.com.
المصدر: Scientific reports [Sci Rep] 2024 Jun 25; Vol. 14 (1), pp. 14655. Date of Electronic Publication: 2024 Jun 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Lactation*/physiology , Osteocytes*/metabolism , Osteocytes*/physiology , Bone Remodeling*/physiology , X-Ray Microtomography*, Animals ; Female ; Mice ; Matrix Metalloproteinase 13/metabolism
مستخلص: Osteocytes locally remodel their surrounding tissue through perilacunar canalicular remodeling (PLR). During lactation, osteocytes remove minerals to satisfy the metabolic demand, resulting in increased lacunar volume, quantifiable with synchrotron X-ray radiation micro-tomography (SRµCT). Although the effects of lactation on PLR are well-studied, it remains unclear whether PLR occurs uniformly throughout the bone and what mechanisms prevent PLR from undermining bone quality. We used SRµCT imaging to conduct an in-depth spatial analysis of the impact of lactation and osteocyte-intrinsic MMP13 deletion on PLR in murine bone. We found larger lacunae undergoing PLR are located near canals in the mid-cortex or endosteum. We show lactation-induced hypomineralization occurs 14 µm away from lacunar edges, past a hypermineralized barrier. Our findings reveal that osteocyte-intrinsic MMP13 is crucial for lactation-induced PLR near lacunae in the mid-cortex but not for whole-bone resorption. This research highlights the spatial control of PLR on mineral distribution during lactation.
(© 2024. The Author(s).)
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معلومات مُعتمدة: 5T42OH008414-16 United States OH NIOSH CDC HHS; R01DE019284 United States NH NIH HHS; AR066262 United States NH NIH HHS; DE-AC02-05CH11231 U.S. Department of Energy
المشرفين على المادة: EC 3.4.24.- (Matrix Metalloproteinase 13)
تواريخ الأحداث: Date Created: 20240625 Date Completed: 20240625 Latest Revision: 20240625
رمز التحديث: 20240626
DOI: 10.1038/s41598-024-63645-0
PMID: 38918485
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-024-63645-0