دورية أكاديمية
T-cell exhaustion in multiple myeloma.
| العنوان: | T-cell exhaustion in multiple myeloma. |
|---|---|
| المؤلفون: | Żyłka K; The Department of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Poznań, Poland., Kubicki T; The Department of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Poznań, Poland.; Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL, USA., Gil L; The Department of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Poznań, Poland., Dytfeld D; The Department of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Poznań, Poland. |
| المصدر: | Expert review of hematology [Expert Rev Hematol] 2024 Jul; Vol. 17 (7), pp. 295-312. Date of Electronic Publication: 2024 Jun 26. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 101485942 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1747-4094 (Electronic) Linking ISSN: 17474094 NLM ISO Abbreviation: Expert Rev Hematol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Abingdon, Oxford : Taylor & Francis Original Publication: London : Expert Reviews |
| مواضيع طبية MeSH: | Multiple Myeloma*/therapy , Multiple Myeloma*/immunology , T-Lymphocytes*/immunology , T-Lymphocytes*/metabolism , Receptors, Chimeric Antigen*/metabolism , Receptors, Chimeric Antigen*/immunology , Immunotherapy, Adoptive*/methods , Immunotherapy, Adoptive*/adverse effects , Antibodies, Bispecific*/therapeutic use, Humans ; T-Cell Exhaustion |
| مستخلص: | Introduction: Chimeric Antigen Receptor (CAR) T-cells and Bispecific Antibodies (BsAb) are the leading platforms for redirecting the immune system against cells expressing the specific antigen, revolutionizing the treatment of hematological malignancies, including multiple myeloma (MM). In MM, drug-resistant relapses are the main therapy-limiting factor and the leading cause of why the disease is still considered incurable. T-cell-engaging therapies hold promise in improving the treatment of MM. However, the effectiveness of these treatments may be hindered by T-cell fitness. T-cell exhaustion is a condition of a gradual decline in effector function, reduced cytokine secretion, and increased expression of inhibitory receptors due to chronic antigen stimulation. Areas Covered: This review examines findings about T-cell exhaustion in MM in the context of T-cell redirecting BsAbs and CAR-T treatment. Expert Opinion: The fitness of T-cells has become an important factor in the development of T-cell redirecting therapies. The way T-cell exhaustion relates to these therapies could affect the further development of CAR and BsAbs technologies, as well as the strategies used for clinical use. Therefore, this review aims to explore the current understanding of T-cell exhaustion in MM and its relationship to these therapies. |
| فهرسة مساهمة: | Keywords: BsAbs; CAR-T; Multiple myeloma; T-cell exhaustion; T-lymphocytes; bispecific antibodies; chimeric antigen receptor; hematologic neoplasms |
| المشرفين على المادة: | 0 (Receptors, Chimeric Antigen) 0 (Antibodies, Bispecific) |
| تواريخ الأحداث: | Date Created: 20240626 Date Completed: 20240626 Latest Revision: 20240626 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1080/17474086.2024.2370552 |
| PMID: | 38919090 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1747-4094 |
|---|---|
| DOI: | 10.1080/17474086.2024.2370552 |