دورية أكاديمية
Synthesis, antibacterial and antibiofilm activity of new 1,2,3,5-tetrazine derivatives from coupling reactions of diazonium salt of 2-amino-6-nitrobenzothiazole with diverse substituted 2-aminobenzothiazole derivatives.
| العنوان: | Synthesis, antibacterial and antibiofilm activity of new 1,2,3,5-tetrazine derivatives from coupling reactions of diazonium salt of 2-amino-6-nitrobenzothiazole with diverse substituted 2-aminobenzothiazole derivatives. |
|---|---|
| المؤلفون: | Tsemeugne J; University of Yaounde 1, Cameroon. tsemeugne@yahoo.fr., Atuh Bah Y; Laboratory of Natural Products and Applied Organic Synthesis (LANAPOS), Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P.O. Box 812 Yaounde, Republic of Cameroon. yetinyatuh@gmail.com., Tsopmene UJ; Laboratory of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, PO Box 67 Dschang, Cameroon. ulrichtsopmene@gmail.com., Tontsa Tsamo A; Laboratory of Natural Products and Applied Organic Synthesis (LANAPOS), Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P.O. Box 812 Yaounde, Republic of Cameroon. armelletsamo@yahoo.fr., Ndefo Ndefonganga J; Laboratory of Natural Products and Applied Organic Synthesis (LANAPOS), Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P.O. Box 812 Yaounde, Republic of Cameroon. jeromendefo07@gmail.com., Mkounga P; Laboratory of Natural Products and Applied Organic Synthesis (LANAPOS), Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P.O. Box 812 Yaounde, Republic of Cameroon. mpierrendi@yahoo.fr., Fondjo Sopbué E; sopbue@yahoo.fr., Dzoyem JP; Laboratory of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, PO Box 67 Dschang, Cameroon. jean.dzoyem@univ-dschang.org., Nkengfack AE; Laboratory of Natural Products and Applied Organic Synthesis (LANAPOS), Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P.O. Box 812 Yaounde, Republic of Cameroon. ankengf@yahoo.fr. |
| المصدر: | Acta chimica Slovenica [Acta Chim Slov] 2024 Jun 10; Vol. 71 (2), pp. 353-362. Date of Electronic Publication: 2024 Jun 10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Slovenian Chemical Society Country of Publication: Slovenia NLM ID: 101247110 Publication Model: Electronic Cited Medium: Internet ISSN: 1580-3155 (Electronic) Linking ISSN: 13180207 NLM ISO Abbreviation: Acta Chim Slov Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Ljubljana : Slovenian Chemical Society, |
| مواضيع طبية MeSH: | Biofilms*/drug effects , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemical synthesis , Microbial Sensitivity Tests* , Staphylococcus aureus*/drug effects , Escherichia coli*/drug effects , Benzothiazoles*/pharmacology , Benzothiazoles*/chemistry , Benzothiazoles*/chemical synthesis, Diazonium Compounds/chemistry ; Diazonium Compounds/pharmacology |
| مستخلص: | The coupling reaction of diazonium ion of 2-amino-6-nitrobenzothiazole at 0-5 °C with distinctly substituted 2-aminobenzothiazole derivatives produced new 1,2,3,5-tetrazine derivatives. It was found that diazotized 2-amino-6-nitrobenzo[d]thiazol reacts with the ring nitrogen atom of varyingly substituted 2-aminobenzothiazole derivatives to yield tetrazine nucleus. The benzene ring of benzothiazole bearing electron donor group and annelated to the tetrazine was further substituted in situ by other 6-nitrobenzo[d]thiazol-2-yl) diazinyl to yield the final product. The structure of the prepared compounds was elucidated using their physical, elemental, and spectroscopic data. The synthesized compounds were tested for their antimicrobial and antibiofilm activities against Staphylococcus aureus and Escherichia coli bacteria. Two of the synthesis tetrazine derivatives exhibited interesting antibiofilm potential. |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Benzothiazoles) 0 (Diazonium Compounds) 0 (aminobenzothiazole compound) |
| تواريخ الأحداث: | Date Created: 20240626 Date Completed: 20240626 Latest Revision: 20240708 |
| رمز التحديث: | 20240708 |
| DOI: | 10.17344/acsi.2023.8550 |
| PMID: | 38919107 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1580-3155 |
|---|---|
| DOI: | 10.17344/acsi.2023.8550 |