دورية أكاديمية
Application of Delta T1 maps for quantitative and objective assessment of extent of resection and survival prediction in glioblastoma.
| العنوان: | Application of Delta T1 maps for quantitative and objective assessment of extent of resection and survival prediction in glioblastoma. |
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| المؤلفون: | Laing BR; Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Prah MA; Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Best BJ; Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Krucoff MO; Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Mueller WM; Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Schmainda KM; Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. |
| المصدر: | Neurosurgery practice [Neurosurg Pract] 2024 Mar; Vol. 5 (1). Date of Electronic Publication: 2024 Jan 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 9918609288906676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2834-4383 (Electronic) Linking ISSN: 28344383 NLM ISO Abbreviation: Neurosurg Pract Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Philadelphia, Pennsylvania] : Wolters Kluwer Health, Inc., [2023]- |
| مستخلص: | Background and Objectives: Gross-total resection (GTR) and low residual tumor volume (RTV) have been associated with increased survival in glioblastoma. Largely due to the subjectivity involved, the determination of GTR and RTV remains difficult in the postoperative setting. In response, the objective of this study is to evaluate the clinical efficacy of an easy-to-use MRI metric, called delta T1 (dT1), to quantify extent of resection (EOR) and RTV, in comparison to radiologist impression, to predict overall survival (OS) in glioblastoma patients. Methods: 59 patients who underwent resection of glioblastoma were retrospectively identified. Delta T1 (dT1) images, automatically created from the difference between calibrated post- and pre-contrast T1-weighted images, were used to quantify EOR and RTV. Kaplan-Meier survival estimates were determined for EOR categories, an RTV cutoff of 5cm 3 and radiologist interpretation of EOR. Multivariate Cox proportional hazard regression analysis was used to evaluate RTV and EOR along with effects related to sex, KPS, MGMT, and age on OS. Results: Kaplan-Meier analysis revealed a statistically significant difference in median OS for a dT1-determined RTV cutoff of 5 cm 3 (P=.0024, HR=2.18 (1.232-3.856)), but not for radiological impression (P=0.666) or dT1-determined EOR (P=0.0803), which was limited to a comparison between partial and subtotal resections. Furthermore, when covariates were accounted for in multivariate Cox regression, significant differences in OS were retained for dT1-determined RTV. Additionally, a significantly strong yet short-term effect of MGMT methylation status on OS was revealed for each RTV and EOR model. Conclusion: The utility of dT1 maps to quantify EOR and RTV in glioblastoma and predict survival, suggests an emerging role for dT1s with relevance for intraoperative MRI, neuro-navigation and postoperative disease surveillance. |
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| معلومات مُعتمدة: | R01 CA221938 United States CA NCI NIH HHS; R01 CA255123 United States CA NCI NIH HHS; U01 CA176110 United States CA NCI NIH HHS; UH3 CA255133 United States CA NCI NIH HHS |
| فهرسة مساهمة: | Keywords: Delta T1; RANO-resect; extent of resection (EOR); glioblastoma; residual tumor volume (RTV) |
| تواريخ الأحداث: | Date Created: 20240626 Latest Revision: 20240628 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC11198967 |
| PMID: | 38919518 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2834-4383 |
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