دورية أكاديمية
Diagnostic performance of classification criteria for systemic lupus erythematosus: A validation study from Singapore.
| العنوان: | Diagnostic performance of classification criteria for systemic lupus erythematosus: A validation study from Singapore. |
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| المؤلفون: | Teh KL; Rheumatology and Immunology Service, Department of Paediatric Subspecialties, KK Women's and Children's Hospital, Singapore.; Duke-NUS Medical School, Singapore., Das L; Rheumatology and Immunology Service, Department of Paediatric Subspecialties, KK Women's and Children's Hospital, Singapore., Huang J; Rheumatology and Immunology Service, Department of Paediatric Subspecialties, KK Women's and Children's Hospital, Singapore., Book YX; Rheumatology and Immunology Service, Department of Paediatric Subspecialties, KK Women's and Children's Hospital, Singapore., Hoh SF; Department of Nursing, KK Women's and Children's Hospital, Singapore., Gao X; Department of Nursing, KK Women's and Children's Hospital, Singapore., Arkachaisri T; Rheumatology and Immunology Service, Department of Paediatric Subspecialties, KK Women's and Children's Hospital, Singapore.; Duke-NUS Medical School, Singapore. |
| المصدر: | Annals of the Academy of Medicine, Singapore [Ann Acad Med Singap] 2024 May 10; Vol. 53 (5), pp. 277-285. Date of Electronic Publication: 2024 May 10. |
| نوع المنشور: | Journal Article; Validation Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academy Of Medicine, Singapore Country of Publication: Singapore NLM ID: 7503289 Publication Model: Electronic Cited Medium: Internet ISSN: 2972-4066 (Electronic) Linking ISSN: 03044602 NLM ISO Abbreviation: Ann Acad Med Singap Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Singapore : Academy Of Medicine, Singapore Original Publication: Singapore. |
| مواضيع طبية MeSH: | Lupus Erythematosus, Systemic*/diagnosis , Lupus Erythematosus, Systemic*/classification , Sensitivity and Specificity*, Humans ; Singapore ; Female ; Male ; Child ; Case-Control Studies ; Adolescent ; Retrospective Studies ; Age of Onset |
| مستخلص: | Introduction: Classification criteria for systemic lupus erythematosus (SLE) include American College of Rheumatology (ACR) 1997, Systemic Lupus Erythematosus International Collaborating Clinics (SLICC) 2012 and European Alliance of Associations for Rheumatology (EULAR)/ACR 2019 criteria. Their performance in an Asian childhood-onset SLE (cSLE) population remains unclear as the clinical manifestations differ. We aim to evaluate the diagnostic performance in a cSLE cohort in Singapore. Method: Cases were physician-diagnosed cSLE, while controls were children with mixed and undifferentiated connective tissue disease that posed an initial diagnostic challenge. Data were retrospec-tively reviewed to establish the 3 criteria fulfilled at diagnosis and over time. Results: The study population included 120 cSLE cases and 36 controls. At diagnosis, 102 (85%) patients fulfilled all criteria. SLICC-2012 had the highest sensitivity (97.5%, 95% confidence interval [CI] 92.3-99.5), while ACR-1997 had the highest specificity (91.7%, 95% CI 77.5-98.3). All criteria had diagnostic accuracies at more than 85%. Over time, 113 (94%) fulfilled all criteria. SLICC-2012 remained the criteria with the highest sensitivity (99.2%, 95% CI 95.4-99.9), while ACR-1997 had the highest specificity (75.0%, 95% CI 57.8-87.9). Only SLICC-2012 and ACR-1997 had more than 85% diagnostic accuracy over time. Using a cutoff score of ≥ 13 for EULAR/ACR-2019 criteria resulted in improved diagnostic performance. Conclusion: SLICC-2012 criteria had the highest sensitivity early in the disease course in this first study evaluating the SLE classification criteria performance in a Southeast Asian cSLE cohort, while the ACR-1997 criteria had the highest specificity. Using a cutoff score of ≥ 13 for EULAR/ACR-2019 improved the diagnostic performance. Competing Interests: The authors have declared no conflicts of interest. |
| فهرسة مساهمة: | Keywords: classification criteria; paediatrics; rheumatology; systemic lupus erythematosus; validation |
| تواريخ الأحداث: | Date Created: 20240626 Date Completed: 20240626 Latest Revision: 20240626 |
| رمز التحديث: | 20240626 |
| DOI: | 10.47102/annals-acadmedsg.2023216 |
| PMID: | 38920219 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2972-4066 |
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| DOI: | 10.47102/annals-acadmedsg.2023216 |