دورية أكاديمية
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Organ-Specific Gene Expression Control Using DNA Origami-Based Nanodevices.

التفاصيل البيبلوغرافية
العنوان: Organ-Specific Gene Expression Control Using DNA Origami-Based Nanodevices.
المؤلفون: Liu Y; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210 People's Republic of China., Wang R; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210 People's Republic of China., Chen Q; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210 People's Republic of China., Chang Y; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210 People's Republic of China., Chen Q; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210 People's Republic of China., Fukumoto K; Institute for Protein Research, Osaka University, Osaka 565-0871, Japan.; RIKEN Center for Biosystems Dynamics Research, Yokohama 230-0045, Japan., Wang B; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210 People's Republic of China., Yu J; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210 People's Republic of China., Luo C; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210 People's Republic of China., Ma J; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210 People's Republic of China., Chen X; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210 People's Republic of China.; Zhejiang Provincial Key Laboratory of Pancreatic Disease Hangzhou, Zhejiang University School of Medicine First Affiliated Hospital, Zhejiang 310009, People's Republic of China., Murayama Y; RIKEN Center for Biosystems Dynamics Research, Yokohama 230-0045, Japan., Umeda K; Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan., Kodera N; Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan., Harada Y; Institute for Protein Research, Osaka University, Osaka 565-0871, Japan., Sekine SI; RIKEN Center for Biosystems Dynamics Research, Yokohama 230-0045, Japan., Li J; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210 People's Republic of China.; Gene Editing Center, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, People's Republic of China., Tadakuma H; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210 People's Republic of China.; Gene Editing Center, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, People's Republic of China.
المصدر: Nano letters [Nano Lett] 2024 Jul 10; Vol. 24 (27), pp. 8410-8417. Date of Electronic Publication: 2024 Jun 26.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101088070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-6992 (Electronic) Linking ISSN: 15306984 NLM ISO Abbreviation: Nano Lett Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : American Chemical Society, c2001-
مواضيع طبية MeSH: DNA*/chemistry , Nanotechnology*/methods, Animals ; Mice ; Nanostructures/chemistry ; Nanoparticles/chemistry ; RNA, Small Interfering/chemistry ; RNA, Small Interfering/genetics ; RNA, Messenger/genetics ; RNA, Messenger/chemistry ; Gene Expression Regulation ; Organ Specificity ; Nucleic Acid Conformation ; Lipids/chemistry
مستخلص: Nanodevices that function in specific organs or cells are one of the ultimate goals of synthetic biology. The recent progress in DNA nanotechnology such as DNA origami has allowed us to construct nanodevices to deliver a payload (e.g., drug) to the tumor. However, delivery to specific organs remains difficult due to the fragility of the DNA nanostructure and the low targeting capability of the DNA nanostructure. Here, we constructed tough DNA origami that allowed us to encapsulate the DNA origami into lipid-based nanoparticles (LNPs) under harsh conditions (low pH), harnessing organ-specific delivery of the gene of interest (GOI). We found that DNA origami-encapsulated LNPs can increase the functionality of payload GOIs (mRNA and siRNA) inside mouse organs through the contribution from different LNP structures revealed by cryogenic electron microscope (Cryo-EM). These data should be the basis for future organ-specific gene expression control using DNA origami nanodevices.
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فهرسة مساهمة: Keywords: Cryo-EM; DNA origami; LNP; gene expression
المشرفين على المادة: 9007-49-2 (DNA)
0 (RNA, Small Interfering)
0 (RNA, Messenger)
0 (Lipids)
تواريخ الأحداث: Date Created: 20240626 Date Completed: 20240710 Latest Revision: 20240717
رمز التحديث: 20240717
مُعرف محوري في PubMed: PMC11249008
DOI: 10.1021/acs.nanolett.4c02104
PMID: 38920331
قاعدة البيانات: MEDLINE
الوصف
تدمد:1530-6992
DOI:10.1021/acs.nanolett.4c02104