دورية أكاديمية
How to Overcome a Snail? Identification of Putative Neurotoxins of Snail-Feeding Firefly Larvae (Coleoptera: Lampyridae, Lampyris noctiluca ).
العنوان: | How to Overcome a Snail? Identification of Putative Neurotoxins of Snail-Feeding Firefly Larvae (Coleoptera: Lampyridae, Lampyris noctiluca ). |
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المؤلفون: | Krämer J; Institute of Zoology, University of Cologne, Zuelpicher Strasse 47b, 50674 Cologne, Germany.; Institute for Insect Biotechnology, Justus-Liebig-University of Giessen, Heinrich-Buff-Ring 26-32, 35392 Giessen, Germany., Hölker P; Institute of Zoology, University of Cologne, Zuelpicher Strasse 47b, 50674 Cologne, Germany., Predel R; Institute of Zoology, University of Cologne, Zuelpicher Strasse 47b, 50674 Cologne, Germany. |
المصدر: | Toxins [Toxins (Basel)] 2024 Jun 14; Vol. 16 (6). Date of Electronic Publication: 2024 Jun 14. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101530765 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6651 (Electronic) Linking ISSN: 20726651 NLM ISO Abbreviation: Toxins (Basel) Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel : MDPI |
مواضيع طبية MeSH: | Larva*/metabolism , Neurotoxins*/toxicity , Neurotoxins*/metabolism , Coleoptera*/metabolism , Snails*/metabolism, Animals ; Predatory Behavior |
مستخلص: | The larvae of some lampyrid beetles are highly specialized predators of snails. They have been observed to climb on the shells of their prey and use this exposed position to bite and inject secretions potentially originating from the midgut. Besides serving the purpose of extra-oral digestion (EOD), injected compounds also seem to have a paralyzing effect. Up to now, the toxins causing this paralyzing activity have not been identified. In the current study, we provide a first compositional analysis of the midgut secretion from lampyrid larvae, with a focus on identifying putative neurotoxins causing the observed paralyzing effect. For this purpose, we utilized a combined proteo-transcriptomic approach to characterize the compounds present in the midgut secretion of larval stages of Lampyris noctiluca . In terms of the absolute numbers of identified compounds, the midgut secretion is dominated by hydrolyzing enzymes comprising peptidases, carboxylesterases, and glycosidases. However, when considering expression levels, a few rather short cysteine-rich peptides exceed all other compounds. Some of these compounds show moderate similarity to putative neurotoxins identified in the venom of other arthropods and could be responsible for paralyzing effects. In addition to these potential toxins, we provide a list of peptides typical of the midgut secretion of L. noctiluca , supplemented by the corresponding precursor sequences. |
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معلومات مُعتمدة: | Does not apply Studienstiftung des deutschen Volkes |
فهرسة مساهمة: | Keywords: extra-oral digestion; lampyrid beetle larvae; neglected venomous animals; neurotoxin; venom |
المشرفين على المادة: | 0 (Neurotoxins) |
تواريخ الأحداث: | Date Created: 20240626 Date Completed: 20240626 Latest Revision: 20240629 |
رمز التحديث: | 20240629 |
مُعرف محوري في PubMed: | PMC11209139 |
DOI: | 10.3390/toxins16060272 |
PMID: | 38922166 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2072-6651 |
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DOI: | 10.3390/toxins16060272 |