دورية أكاديمية
أعرض في EDS

How to Overcome a Snail? Identification of Putative Neurotoxins of Snail-Feeding Firefly Larvae (Coleoptera: Lampyridae, Lampyris noctiluca ).

التفاصيل البيبلوغرافية
العنوان: How to Overcome a Snail? Identification of Putative Neurotoxins of Snail-Feeding Firefly Larvae (Coleoptera: Lampyridae, Lampyris noctiluca ).
المؤلفون: Krämer J; Institute of Zoology, University of Cologne, Zuelpicher Strasse 47b, 50674 Cologne, Germany.; Institute for Insect Biotechnology, Justus-Liebig-University of Giessen, Heinrich-Buff-Ring 26-32, 35392 Giessen, Germany., Hölker P; Institute of Zoology, University of Cologne, Zuelpicher Strasse 47b, 50674 Cologne, Germany., Predel R; Institute of Zoology, University of Cologne, Zuelpicher Strasse 47b, 50674 Cologne, Germany.
المصدر: Toxins [Toxins (Basel)] 2024 Jun 14; Vol. 16 (6). Date of Electronic Publication: 2024 Jun 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101530765 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6651 (Electronic) Linking ISSN: 20726651 NLM ISO Abbreviation: Toxins (Basel) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مواضيع طبية MeSH: Larva*/metabolism , Neurotoxins*/toxicity , Neurotoxins*/metabolism , Coleoptera*/metabolism , Snails*/metabolism, Animals ; Predatory Behavior
مستخلص: The larvae of some lampyrid beetles are highly specialized predators of snails. They have been observed to climb on the shells of their prey and use this exposed position to bite and inject secretions potentially originating from the midgut. Besides serving the purpose of extra-oral digestion (EOD), injected compounds also seem to have a paralyzing effect. Up to now, the toxins causing this paralyzing activity have not been identified. In the current study, we provide a first compositional analysis of the midgut secretion from lampyrid larvae, with a focus on identifying putative neurotoxins causing the observed paralyzing effect. For this purpose, we utilized a combined proteo-transcriptomic approach to characterize the compounds present in the midgut secretion of larval stages of Lampyris noctiluca . In terms of the absolute numbers of identified compounds, the midgut secretion is dominated by hydrolyzing enzymes comprising peptidases, carboxylesterases, and glycosidases. However, when considering expression levels, a few rather short cysteine-rich peptides exceed all other compounds. Some of these compounds show moderate similarity to putative neurotoxins identified in the venom of other arthropods and could be responsible for paralyzing effects. In addition to these potential toxins, we provide a list of peptides typical of the midgut secretion of L. noctiluca , supplemented by the corresponding precursor sequences.
References: Cell Tissue Res. 2019 Sep;377(3):505-525. (PMID: 31359140)
Toxins (Basel). 2018 Jan 05;10(1):. (PMID: 29303983)
Annu Rev Genomics Hum Genet. 2009;10:483-511. (PMID: 19640225)
Biomolecules. 2021 Mar 30;11(4):. (PMID: 33808208)
Bioinformatics. 2014 Aug 1;30(15):2114-20. (PMID: 24695404)
Nat Biotechnol. 2022 Jul;40(7):1023-1025. (PMID: 34980915)
Toxicon. 2018 Nov;154:15-27. (PMID: 30267720)
Arthropod Struct Dev. 2020 May;56:100931. (PMID: 32203883)
Proc Natl Acad Sci U S A. 2020 May 26;117(21):11399-11408. (PMID: 32398368)
Proteins. 2005 Apr 1;59(1):131-40. (PMID: 15688451)
PeerJ. 2019 Dec 16;7:e8080. (PMID: 31871834)
BMC Genomics. 2016 Sep 07;17:716. (PMID: 27604083)
Nucleic Acids Res. 2021 Jan 8;49(D1):D480-D489. (PMID: 33237286)
Nucleic Acids Res. 2022 Jan 7;50(D1):D543-D552. (PMID: 34723319)
Front Pharmacol. 2020 Jul 24;11:1132. (PMID: 32848750)
Mol Biol Evol. 2019 Dec 1;36(12):2748-2763. (PMID: 31396628)
Toxicon. 2021 Oct 15;201:92-104. (PMID: 34416254)
Nat Biotechnol. 2011 May 15;29(7):644-52. (PMID: 21572440)
J Neurobiol. 1991 Jan;22(1):74-84. (PMID: 2010751)
Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17534-9. (PMID: 24082113)
Nat Methods. 2022 Jun;19(6):679-682. (PMID: 35637307)
Insect Mol Biol. 2018 Aug;27(4):505-511. (PMID: 29656567)
Toxicon. 2015 Sep;103:188-95. (PMID: 26166305)
Biomolecules. 2020 Jun 30;10(7):. (PMID: 32630016)
Biol Rev Camb Philos Soc. 2014 May;89(2):450-65. (PMID: 24102715)
Toxins (Basel). 2017 Jul 26;9(8):. (PMID: 28933727)
FASEB J. 2012 Dec;26(12):5141-51. (PMID: 22972919)
Annu Rev Entomol. 1982;27:339-68. (PMID: 7044266)
Toxicon. 2012 Mar 15;59(4):464-71. (PMID: 21194543)
Mol Biol Evol. 2014 Mar;31(3):546-59. (PMID: 24425781)
Bioinformatics. 2015 Oct 1;31(19):3210-2. (PMID: 26059717)
PLoS One. 2017 Jul 19;12(7):e0180762. (PMID: 28723914)
Nature. 2021 Aug;596(7873):583-589. (PMID: 34265844)
Int J Mol Sci. 2022 Sep 20;23(19):. (PMID: 36232328)
Toxins (Basel). 2014 Dec 19;6(12):3488-551. (PMID: 25533518)
Nucleic Acids Res. 2022 Jan 7;50(D1):D20-D26. (PMID: 34850941)
Arch Insect Biochem Physiol. 2015 Feb;88(2):101-10. (PMID: 25256903)
Front Physiol. 2020 Mar 05;11:191. (PMID: 32194442)
Gigascience. 2022 May 18;11:. (PMID: 35640874)
PeerJ. 2021 Sep 20;9:e12121. (PMID: 34616609)
Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3750-3755. (PMID: 28320941)
Toxins (Basel). 2019 Aug 25;11(9):. (PMID: 31450685)
Curr Opin Insect Sci. 2020 Oct;41:86-91. (PMID: 32823203)
Insect Sci. 2022 Apr;29(2):411-429. (PMID: 34296820)
Toxins (Basel). 2019 Oct 22;11(10):. (PMID: 31652611)
Biochem Pharmacol. 2020 Nov;181:114096. (PMID: 32535105)
Biochem Pharmacol. 2020 Nov;181:114043. (PMID: 32445870)
معلومات مُعتمدة: Does not apply Studienstiftung des deutschen Volkes
فهرسة مساهمة: Keywords: extra-oral digestion; lampyrid beetle larvae; neglected venomous animals; neurotoxin; venom
المشرفين على المادة: 0 (Neurotoxins)
تواريخ الأحداث: Date Created: 20240626 Date Completed: 20240626 Latest Revision: 20240629
رمز التحديث: 20240629
مُعرف محوري في PubMed: PMC11209139
DOI: 10.3390/toxins16060272
PMID: 38922166
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6651
DOI:10.3390/toxins16060272