دورية أكاديمية
أعرض في EDS

Botulinum Toxin and Deep Brain Stimulation in Dystonia.

التفاصيل البيبلوغرافية
العنوان: Botulinum Toxin and Deep Brain Stimulation in Dystonia.
المؤلفون: de Souza JCC; Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo 05403-000, Brazil., Falcone ACM; Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo 05403-000, Brazil., Barbosa RMG; Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo 05403-000, Brazil., Soares MC; Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo 05403-000, Brazil., Munhoz R; Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Toronto, ON M5T 2S8, Canada., Farah M; Cajuru University Hospital, Pontíficia Universidade Católica do Paraná, Curitiba 80050-350, Brazil., Capato T; Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo 05403-000, Brazil.; Department of Neurology, Radboud University Medical Center, 6525 Nijmegen, The Netherlands., Casagrande SCB; Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo 05403-000, Brazil., Cordellini MF; Instituto de Neurologia de Curitiba, Curitiba 81210-310, Brazil., de Castro Micheli G; Department of Neurology, University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro 21941-617, Brazil., Limongi JCP; Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo 05403-000, Brazil., Barbosa ER; Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo 05403-000, Brazil., Listik C; Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo 05403-000, Brazil., Cury RG; Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo 05403-000, Brazil.; Hospital Israelita Albert Einstein, São Paulo 05652-900, Brazil.
المصدر: Toxins [Toxins (Basel)] 2024 Jun 20; Vol. 16 (6). Date of Electronic Publication: 2024 Jun 20.
نوع المنشور: Journal Article; Multicenter Study
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101530765 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6651 (Electronic) Linking ISSN: 20726651 NLM ISO Abbreviation: Toxins (Basel) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مواضيع طبية MeSH: Deep Brain Stimulation* , Dystonia*/therapy , Dystonia*/drug therapy, Humans ; Retrospective Studies ; Male ; Female ; Middle Aged ; Adult ; Botulinum Toxins/therapeutic use ; Botulinum Toxins/administration & dosage ; Aged ; Treatment Outcome ; Quality of Life
مستخلص: Deep Brain Stimulation (DBS) is a recognized treatment for different dystonia subtypes and has been approved by the Food and Drug Administration (FDA) since 2003. The European Federation of Neurological Societies (EFNS) and the International Parkinson and Movement Disorders Society (MDS) recommend DBS for dystonia after failure of botulinum toxin (BoNT) and other oral medications for dystonia treatment. In addition, several long-term studies have demonstrated the continuous efficacy of DBS on motor and quality of life (QoL) scores. However, there are only a few reports comparing the overall impact of surgical treatment in BoNT protocols (e.g., dosage and number of selected muscles before and after surgery). This retrospective multicenter chart-review study analyzed botulinum toxin total dosage and dosage per muscle in 23 dystonic patients before and after DBS surgery. The study's primary outcome was to analyze whether there was a reduction in BoNT dosage after DBS surgery. The mean BoNT dosages difference between baseline and post-surgery was 293.4 units for 6 months, 292.6 units for 12 months, and 295.2 units at the last visit. The median total dose of BoNT in the preoperative period was 800 units (N = 23). At the last visit, the median was 700 units ( p = 0.05). This represents a 12.5% reduction in BoNT median dosage. In conclusion, despite the limitations of this retrospective study, there was a significant reduction in BoNT doses after DBS surgery in patients with generalized dystonia.
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فهرسة مساهمة: Keywords: Deep Brain Stimulation; abobotulinum toxinA; botulinum toxin; dystonia; onabotulinum toxinA
المشرفين على المادة: EC 3.4.24.69 (Botulinum Toxins)
تواريخ الأحداث: Date Created: 20240626 Date Completed: 20240626 Latest Revision: 20240629
رمز التحديث: 20240629
مُعرف محوري في PubMed: PMC11209614
DOI: 10.3390/toxins16060282
PMID: 38922176
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6651
DOI:10.3390/toxins16060282