دورية أكاديمية
Dog leukocyte antigen genotyping across class I and class II genes in beagle dogs as laboratory animals.
| العنوان: | Dog leukocyte antigen genotyping across class I and class II genes in beagle dogs as laboratory animals. |
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| المؤلفون: | Konno H; Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd., 1-16-13 Kita-Kasai, Edogawa-ku, Tokyo, 134-8630, Japan. hiroya.konno@daiichisankyo.com., Miyamae J; Faculty of Veterinary Medicine, Okayama University of Science, 1-3 Ikoino-oka, Imabari, Japan., Kataoka H; Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd., 1-16-13 Kita-Kasai, Edogawa-ku, Tokyo, 134-8630, Japan., Akai M; Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd., 1-16-13 Kita-Kasai, Edogawa-ku, Tokyo, 134-8630, Japan., Miida H; Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd., 1-16-13 Kita-Kasai, Edogawa-ku, Tokyo, 134-8630, Japan., Tsuchiya Y; Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd., 1-16-13 Kita-Kasai, Edogawa-ku, Tokyo, 134-8630, Japan. |
| المصدر: | Immunogenetics [Immunogenetics] 2024 Aug; Vol. 76 (4), pp. 261-270. Date of Electronic Publication: 2024 Jun 26. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Verlag Country of Publication: United States NLM ID: 0420404 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1211 (Electronic) Linking ISSN: 00937711 NLM ISO Abbreviation: Immunogenetics Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Springer Verlag, |
| مواضيع طبية MeSH: | Models, Animal* , Dogs*/genetics , Genes, MHC Class I*/genetics , Genes, MHC Class II*/genetics , Genotype*, Animals ; Genetic Variation ; Haplotypes ; Homozygote ; Species Specificity |
| مستخلص: | Dog leukocyte antigen (DLA) polymorphisms have been found to be associated with inter-individual variations in the risk, susceptibility, and severity of immune-related phenomena. While DLA class II genes have been extensively studied, less research has been performed on the polymorphisms of DLA class I genes, especially in beagle dogs commonly used as laboratory animals for safety evaluations in drug development. We genotyped four DLA class I genes and four DLA class II genes by locus-specific Sanger sequencing using 93 laboratory beagle dogs derived from two different strains: TOYO and Marshall. The results showed that, for DLA class I genes, 11, 4, 1, and 2 alleles, including a novel allele, were detected in DLA-88, DLA-12/88L, DLA-64, and DLA-79, while, for DLA class II genes, 1, 10, 6, and 7 alleles were detected in DLA-DRA, DLA-DRB1, DLA-DQA1, and DLA-DQB1, respectively. It was estimated that there were 14 DLA haplotypes, six of which had a frequency of ≥ 5%. Furthermore, when comparing the DLA diversity between TOYO and Marshall strains, the most common alleles and haplotypes differed between them. This is the first study to genotype all DLA loci and determine DLA haplotypes including all DLA class I and class II genes in dogs. Integrating information on the DLA diversity of laboratory beagle dogs should reinforce their benefit as an animal model for understanding various diseases associated with a specific DLA type. (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Beagle dog; Dog leukocyte antigen (DLA); Laboratory animal; Polymorphism |
| تواريخ الأحداث: | Date Created: 20240626 Date Completed: 20240715 Latest Revision: 20240715 |
| رمز التحديث: | 20240715 |
| DOI: | 10.1007/s00251-024-01344-w |
| PMID: | 38922357 |
| قاعدة البيانات: | MEDLINE |
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| DOI: | 10.1007/s00251-024-01344-w |