دورية أكاديمية
Arachnoid granulations in idiopathic intracranial hypertension: Do they have an influence?
| العنوان: | Arachnoid granulations in idiopathic intracranial hypertension: Do they have an influence? |
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| المؤلفون: | Schievelkamp AH; Department of Neuroradiology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany., Wägele P; Department of Neuroradiology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany., Hattingen E; Department of Neuroradiology, Goethe University Frankfurt, University Hospital Frankfurt am Main, Frankfurt/Main, Germany. |
| المصدر: | Headache [Headache] 2024 Jul-Aug; Vol. 64 (7), pp. 722-728. Date of Electronic Publication: 2024 Jun 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: United States NLM ID: 2985091R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-4610 (Electronic) Linking ISSN: 00178748 NLM ISO Abbreviation: Headache Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2008- > : Hoboken, NJ : Wiley Original Publication: St. Louis : American Association for the Study of Headache |
| مواضيع طبية MeSH: | Pseudotumor Cerebri*/physiopathology , Pseudotumor Cerebri*/diagnostic imaging , Pseudotumor Cerebri*/complications , Magnetic Resonance Imaging* , Arachnoid*/diagnostic imaging , Arachnoid*/pathology , Arachnoid*/physiopathology , Cranial Sinuses*/diagnostic imaging , Cranial Sinuses*/physiopathology , Cranial Sinuses*/pathology, Humans ; Female ; Adult ; Male ; Retrospective Studies ; Case-Control Studies ; Middle Aged ; Young Adult |
| مستخلص: | Objective: The aim of this study was to investigate whether the relative narrowing of the dural venous sinuses by arachnoid granulations (AGs) is more pronounced in patients with idiopathic intracranial hypertension (IIH) compared to healthy controls. Background: IIH is characterized by increased intracranial pressure, which is associated with symptoms such as headache and visual disturbances. The role of cerebral venous drainage obstruction in IIH is the subject of ongoing research. Materials and Methods: In this retrospective case-control study, 3D contrast-enhanced magnetic resonance images of a cohort of 43 patients with IIH were evaluated for (1) the number of AGs per venous sinus and (2) the diameters of the dural venous sinuses at the site of an AG and at standardized measurement points. In addition, the minimum width of the transverse/sigmoid sinus was measured. All data were compared to the same data from a cohort of 43 control participants. Results: Patients with IIH showed less relative sinus narrowing by AG compared to controls (median: 7%, interquartile range [IQR] 10% vs. 11%, IQR 9% in controls; p = 0.009). In patients with IIH, sinus diameter was larger at the site of an AG (70 ± 25 mm 2 ) compared to its diameter at the standardized measurement point (48 ± 23 mm 2 ; p = 0.010). In the superior sagittal sinus (SSS), patients with IIH had smaller AGs (median: 3 mm 2 , IQR 2 mm 2 vs. 5 mm 2 , IQR 3 mm 2 in controls; p = 0.023) while the respective sinus segment was larger (median: 69 mm 2 ; IQR 21 mm 2 vs. 52 mm 2 , IQR 26 mm 2 in controls; p = 0.002). The right transverse sinus was narrower in patients with IIH (41 ± 21 mm vs. 57 ± 20 mm in controls; p < 0.001). Conclusions: In contrast to our hypothesis, patients with IIH showed less pronounced relative sinus narrowing by AG compared to controls, especially within the SSS, where AGs were smaller and the corresponding sinus segment wider. Smaller AGs could result in lower cerebrospinal fluid resorption, favoring the development of IIH. Conversely, the smaller AGs could also be a consequence of IIH due to backpressure in the SSS because of the narrower transverse/sigmoid sinus, which widens the SSS and compresses the AG. (© 2024 The Author(s). Headache: The Journal of Head and Face Pain published by Wiley Periodicals LLC on behalf of American Headache Society.) |
| References: | Friedman DI, Jacobson DM. Diagnostic criteria for idiopathic intracranial hypertension. Neurology. 2002;59:1492‐1495. doi:10.1212/01.WNL.0000029570.69134.1B. Ahmad SR, Moss HE. Update on the diagnosis and treatment of idiopathic intracranial hypertension. Semin Neurol. 2019;39:682‐691. doi:10.1055/s-0039-1698744. Degnan AJ, Levy LM. Pseudotumor cerebri: brief review of clinical syndrome and imaging findings. Am J Neuroradiol. 2011;32:1986‐1993. doi:10.3174/ajnr.A2404. Mollan SP, Grech O, Sinclair AJ. Headache attributed to idiopathic intracranial hypertension and persistent post‐idiopathic intracranial hypertension headache: a narrative review. Headache. 2021;61:808‐816. doi:10.1111/head.14125. Markey KA, Mollan SP, Jensen RH, Sinclair AJ. Understanding idiopathic intracranial hypertension: mechanisms, management, and future directions. Lancet Neurol. 2016;15:78‐91. doi:10.1016/s1474-4422(15)00298-7. Raoof N, Sharrack B, Pepper IM, Hickman SJ. The incidence and prevalence of idiopathic intracranial hypertension in Sheffield, UK. Eur J Neurol. 2011;18:1266‐1268. doi:10.1111/j.1468-1331.2011.03372.x. Radhakrishnan K, Ahlskog JE, Cross SA, et al. Idiopathic intracranial hypertension (Pseudotumor cerebri). Descriptive epidemiology in Rochester, Minn, 1976 to 1990. Arch Neurol. 1993;50:78‐80. doi:10.1001/archneur.1993.00540010072020. Durcan FJ, Corbett JJ, Wall M. The incidence of pseudotumor cerebri. Population studies in Iowa and Louisiana. Arch Neurol. 1988;45:875‐877. doi:10.1001/archneur.1988.00520320065016. Craig JJ, Mulholland DA, Gibson JM. Idiopathic intracranial hypertension; incidence, presenting features and outcome in Northern Ireland (1991–1995). Ulster Med J. 2001;70:31‐35. Kesler A, Gadoth N. Epidemiology of idiopathic intracranial hypertension in Israel. J Neuroophthalmol. 2001;21:12‐14. doi:10.1097/00041327-200103000-00003. Kesler A, Stolovic N, Bluednikov Y, Shohat T. The incidence of idiopathic intracranial hypertension in Israel from 2005 to 2007: results of a nationwide survey. Eur J Neurol. 2014;21:1055‐1059. doi:10.1111/ene.12442. Giridharan N, Patel SK, Ojugbeli A, et al. Understanding the complex pathophysiology of idiopathic intracranial hypertension and the evolving role of venous sinus stenting: a comprehensive review of the literature. Neurosurg Focus. 2018;45:E10. doi:10.3171/2018.4.FOCUS18100. Silbergleit R, Junck L, Gebarski SS, Hatfield MK. Idiopathic intracranial hypertension (Pseudotumor cerebri): MR imaging. Radiology. 1989;170:207‐209. doi:10.1148/radiology.170.1.2909098. Ball AK, Sinclair AJ, Curnow SJ, et al. Elevated cerebrospinal fluid (CSF) leptin in idiopathic intracranial hypertension (IIH): evidence for hypothalamic leptin resistance? Clin Endocrinol. 2009;70:863‐869. doi:10.1111/j.1365-2265.2008.03401.x. O'Reilly MW, Westgate CS, Hornby C, et al. A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics. JCI Insight. 2019;4:e125348. doi:10.1172/jci.insight.125348. Botfield HF, Uldall MS, Westgate CSJ, et al. A glucagon‐like peptide‐1 receptor agonist reduces intracranial pressure in a rat model of hydrocephalus. Sci Transl Med. 2017;9:eaan0972. doi:10.1126/scitranslmed.aan0972. Bezerra ML, Ferreira AC, de Oliveira‐Souza R. Pseudotumor cerebri and glymphatic dysfunction. Front Neurol. 2017;8:734. doi:10.3389/fneur.2017.00734. Eide PK, Pripp AH, Ringstad G, Valnes LM. Impaired glymphatic function in idiopathic intracranial hypertension. Brain Commun. 2021;3:fcab043. doi:10.1093/braincomms/fcab043. Jones O, Cutsforth‐Gregory J, Chen J, Bhatti MT, Huston J, Brinjikji W. Idiopathic intracranial hypertension is associated with a higher burden of visible cerebral perivascular spaces: the glymphatic connection. AJNR Am J Neuroradiol. 2021;42:2160‐2164. doi:10.3174/ajnr.A7326. Mondejar V, Patsalides A. The role of arachnoid granulations and the glymphatic system in the pathophysiology of idiopathic intracranial hypertension. Curr Neurol Neurosci Rep. 2020;20:1‐6. doi:10.1007/s11910-020-01044-4. Arjona A, Delgado F, Fernandez‐Romero E. Intracranial hypertension secondary to giant arachnoid granulations. J Neurol Neurosurg Psychiatry. 2003;74:418. doi:10.1136/jnnp.74.4.418. Spitze A, Malik A, Lee AG. Surgical and endovascular interventions in idiopathic intracranial hypertension. Curr Opin Neurol. 2014;27:69‐74. doi:10.1097/WCO.0000000000000049. |
| فهرسة مساهمة: | Keywords: arachnoid granulations; dural venous sinus; idiopathic intracranial hypertension |
| تواريخ الأحداث: | Date Created: 20240626 Date Completed: 20240710 Latest Revision: 20240830 |
| رمز التحديث: | 20240831 |
| DOI: | 10.1111/head.14776 |
| PMID: | 38922856 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1526-4610 |
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| DOI: | 10.1111/head.14776 |