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Parental Exposure to Morphine Before Conception Decreases Morphine and Cocaine-Induced Locomotor Sensitization in Male Offspring.

التفاصيل البيبلوغرافية
العنوان: Parental Exposure to Morphine Before Conception Decreases Morphine and Cocaine-Induced Locomotor Sensitization in Male Offspring.
المؤلفون: Heidari A; Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran., Hajikarim-Hamedani A; Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran., Hosseindoost S; Pain Research Center, Neuroscience Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.; Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran., Ghane Y; School of Medicine, Tehran University of Medical Sciences, Tehran, Iran., Sadat-Shirazi M; Development, Molecular & Chemical Biology, Tufts University, Boston, Massachusetts, USA., Zarrindast MR; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
المصدر: Developmental psychobiology [Dev Psychobiol] 2024 Sep; Vol. 66 (6), pp. e22514.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley Interscience Country of Publication: United States NLM ID: 0164074 Publication Model: Print Cited Medium: Internet ISSN: 1098-2302 (Electronic) Linking ISSN: 00121630 NLM ISO Abbreviation: Dev Psychobiol Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, NY : Wiley Interscience
Original Publication: New York, Interscience Publishers.
مواضيع طبية MeSH: Morphine*/pharmacology , Morphine*/administration & dosage , Cocaine*/pharmacology , Cocaine*/administration & dosage , Prenatal Exposure Delayed Effects*/physiopathology , Prenatal Exposure Delayed Effects*/chemically induced , Rats, Wistar* , Receptors, Dopamine D2*/metabolism , Receptors, Dopamine D2*/drug effects , Nucleus Accumbens*/drug effects , Nucleus Accumbens*/metabolism , Prefrontal Cortex*/drug effects , Prefrontal Cortex*/metabolism , Locomotion*/drug effects, Animals ; Female ; Male ; Pregnancy ; Rats ; Behavior, Animal/drug effects ; Behavior, Animal/physiology ; Narcotics/pharmacology ; Paternal Exposure/adverse effects ; Dopamine Uptake Inhibitors/pharmacology ; Dopamine Uptake Inhibitors/administration & dosage ; Motor Activity/drug effects ; Motor Activity/physiology
مستخلص: Repeated exposure to abused drugs leads to reorganizing synaptic connections in the brain, playing a pivotal role in the relapse process. Additionally, recent research has highlighted the impact of parental drug exposure before gestation on subsequent generations. This study aimed to explore the influence of parental morphine exposure 10 days prior to pregnancy on drug-induced locomotor sensitization. Adult male and female Wistar rats were categorized into morphine-exposed and control groups. Ten days after their last treatment, they were mated, and their male offspring underwent morphine, methamphetamine, cocaine, and nicotine-induced locomotor sensitization tests. The results indicated increased locomotor activity in both groups after drug exposure, although the changes were attenuated in morphine and cocaine sensitization among the offspring of morphine-exposed parents (MEPs). Western blotting analysis revealed altered levels of D2 dopamine receptors (D2DRs) in the prefrontal cortex and nucleus accumbens of the offspring from MEPs. Remarkably, despite not having direct in utero drug exposure, these offspring exhibited molecular alterations affecting morphine and cocaine-induced sensitization. The diminished sensitization to morphine and cocaine suggested the development of a tolerance phenotype in these offspring. The changes in D2DR levels in the brain might play a role in these adaptations.
(© 2024 Wiley Periodicals LLC.)
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فهرسة مساهمة: Keywords: cocaine; dopamine receptors; locomotor sensitization; morphine; transgenerational inheritance
المشرفين على المادة: 76I7G6D29C (Morphine)
I5Y540LHVR (Cocaine)
0 (Receptors, Dopamine D2)
0 (Narcotics)
0 (Dopamine Uptake Inhibitors)
0 (DRD2 protein, rat)
تواريخ الأحداث: Date Created: 20240626 Date Completed: 20240626 Latest Revision: 20240626
رمز التحديث: 20240627
DOI: 10.1002/dev.22514
PMID: 38922890
قاعدة البيانات: MEDLINE
الوصف
تدمد:1098-2302
DOI:10.1002/dev.22514