دورية أكاديمية
Risk factors for progression from prediabetes to diabetes among older persons with HIV.
| العنوان: | Risk factors for progression from prediabetes to diabetes among older persons with HIV. |
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| المؤلفون: | Masters MC; Northwestern University., Tassiopoulos K; Harvard T. H. Chan School of Public Health., Bao Y; Harvard T. H. Chan School of Public Health., Wu K; Harvard T. H. Chan School of Public Health., Koletar SL; Ohio State University., Rubin LH; Johns Hopkins University., Yang J; Columbia University., Overton ET; University of Alabama at Birmingham and ViiV Healthcare., Letendre S; University of California, San Diego., Brown TT; Johns Hopkins University., Erlandson KM; University of Colorado., Palella FJ; Northwestern University. |
| مؤلفون مشاركون: | ACTG A5322 Study Team |
| المصدر: | AIDS (London, England) [AIDS] 2024 Jun 26. Date of Electronic Publication: 2024 Jun 26. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 8710219 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5571 (Electronic) Linking ISSN: 02699370 NLM ISO Abbreviation: AIDS Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1998- : London, England : Lippincott Williams & Wilkins Original Publication: London : Gower Academic Journals, c1987- |
| مستخلص: | Objective: Risk factors for progression from prediabetes (pre-DM) to diabetes (DM) among people with HIV (PWH) receiving modern antiretroviral therapy (ART) require better characterization. Design: AIDS Clinical Trials Group (ACTG) A5322 (HAILO) was an observational cohort study of PWH ≥40 years old. Participants initiated ART through ACTG randomized clinical trials. Methods: We used Cox proportional hazards regression models to identify risk factors for development of DM among HAILO participants with pre-DM. Results: Among 1035 HAILO participants, 74 (7%) had pre-DM at entry and another 679 (66%) developed pre-DM during follow-up. Of 753 PWH with pre-DM, 167 (22%) developed DM. In multivariable models, the risk of developing DM was greater with higher BMI, lower CD4 count (≤200 cells/ mm3), hypertriglyceridemia, or higher waist circumference at pre-DM diagnosis (p < 0.01). Conclusion: Rates of pre-DM and progression to DM remain high among virally suppressed PWH receiving modern ART regimens. Traditional risks for DM, such as higher BMI or waist circumference, are associated with increased risk of incident DM among PWH with pre-DM. The association between lower CD4 and progression to DM suggests a role for advanced immunodeficiency and inflammation. Further investigation of interventions aimed at preventing DM among PWH with pre-DM is needed. Optimizing prevention and treatment for DM may be an intervenable opportunity to improve long-term outcomes for PWH. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.) |
| معلومات مُعتمدة: | R01 AG054366 United States AG NIA NIH HHS; UM1 AI068634 United States AI NIAID NIH HHS; K23 AG082543 United States AG NIA NIH HHS; P30 AG059988 United States AG NIA NIH HHS; UM1 AI106701 United States AI NIAID NIH HHS; UM1 AI068636 United States AI NIAID NIH HHS |
| تواريخ الأحداث: | Date Created: 20240626 Latest Revision: 20240721 |
| رمز التحديث: | 20240721 |
| DOI: | 10.1097/QAD.0000000000003970 |
| PMID: | 38923420 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1473-5571 |
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| DOI: | 10.1097/QAD.0000000000003970 |