دورية أكاديمية
أعرض في EDS

Construction of organ of Corti organoid to study the effects of berberine sulfate on damaged auditory cells.

التفاصيل البيبلوغرافية
العنوان: Construction of organ of Corti organoid to study the effects of berberine sulfate on damaged auditory cells.
المؤلفون: Zhang J; College of Biological Science and Medical Engineering, Donghua University, Shanghai, People's Republic of China., Liu L; College of Biological Science and Medical Engineering, Donghua University, Shanghai, People's Republic of China., Shen R; Department of Geriatrics, Yueyang Hosptial of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China., Lou X; College of Biological Science and Medical Engineering, Donghua University, Shanghai, People's Republic of China.
المصدر: Journal of biomedical materials research. Part B, Applied biomaterials [J Biomed Mater Res B Appl Biomater] 2024 Jul; Vol. 112 (7), pp. e35439.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101234238 Publication Model: Print Cited Medium: Internet ISSN: 1552-4981 (Electronic) Linking ISSN: 15524973 NLM ISO Abbreviation: J Biomed Mater Res B Appl Biomater Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Hoboken, NJ : John Wiley & Sons, c2003-
مواضيع طبية MeSH: Organ of Corti*/drug effects , Berberine*/pharmacology , Berberine*/chemistry , Tissue Scaffolds*/chemistry, Animals ; Mice ; Organoids/metabolism ; Organoids/drug effects ; Printing, Three-Dimensional ; Alginates/chemistry ; Alginates/pharmacology ; Gelatin/chemistry ; Gelatin/pharmacology ; Hair Cells, Auditory/drug effects ; Hair Cells, Auditory/metabolism ; Tissue Engineering ; Polyvinyl Alcohol/chemistry ; Polyvinyl Alcohol/pharmacology ; Hearing Loss, Sensorineural ; Spiral Ganglion/drug effects ; Spiral Ganglion/metabolism
مستخلص: Sensorineural hearing loss (SNHL) is mainly caused by injury or loss of hair cells (HCs) and associated spiral ganglion neurons (SGNs) in the inner ear. At present, there is still no effective treatment for SNHL in clinic. Recently, advances in organoid bring a promising prospect for research and treatment of SNHL. Meanwhile, three-dimensional (3D) printing provides a tremendous opportunity to construct versatile organoids for tissue engineering and regenerative medicine. In this study, gelatin (Gel), sodium alginate (SA), and polyvinyl alcohol (PVA) were used to fabricate biomimetic scaffold through 3D printing. The organ of Corti derived from neonatal mice inner ear was seeded on the PVA/Gel/SA scaffold to construct organ of Corti organoid. Then, the organ of Corti organoid was used to study the potential protective effects of berberine sulfate on neomycin-juried auditory HCs and SGNs. The results showed that the PVA/Gel/SA biomimetic 3D scaffolds had good cytocompatibilities and mechanical properties. The constructed organoid could maintain organ of Corti activity well in vitro. In addition, the injury intervention results showed that berberine sulfate could significantly inhibit neomycin-induced HC and SGN damage. This study suggests that the fabricated organoid is highly biomimetic to the organ of Corti, which may provide an effective model for drug development, cell and gene therapy for SNHL.
(© 2024 Wiley Periodicals LLC.)
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معلومات مُعتمدة: 20ZR1401200 Foundation of Shanghai Municipal Natural Science; 2021LK093 Budget of Shanghai University of Traditional Chinese Medicine; 2020-1-2 Open Project of Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Metabolic Diseases; 81303012 National Natural Youth Science Foundation of China
فهرسة مساهمة: Keywords: 3D bioprinting; organ of Corti; organoid; sensorineural hearing loss
المشرفين على المادة: 0I8Y3P32UF (Berberine)
0 (Alginates)
9000-70-8 (Gelatin)
9002-89-5 (Polyvinyl Alcohol)
تواريخ الأحداث: Date Created: 20240626 Date Completed: 20240626 Latest Revision: 20240626
رمز التحديث: 20240627
DOI: 10.1002/jbm.b.35439
PMID: 38923766
قاعدة البيانات: MEDLINE
الوصف
تدمد:1552-4981
DOI:10.1002/jbm.b.35439