دورية أكاديمية
Small Molecule MIF Modulation Enhances Ferroptosis by Impairing DNA Repair Mechanisms.
العنوان: | Small Molecule MIF Modulation Enhances Ferroptosis by Impairing DNA Repair Mechanisms. |
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المؤلفون: | Chen D; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, Groningen, 9713 AV, The Netherlands., Zhao C; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, Groningen, 9713 AV, The Netherlands., Zhang J; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, Groningen, 9713 AV, The Netherlands., Knol CWJ; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, Groningen, 9713 AV, The Netherlands., Osipyan A; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, Groningen, 9713 AV, The Netherlands., Majerníková N; Research School of Behavioural and Cognitive Neuroscience, University of Groningen, Groningen, 9713 AV, The Netherlands.; Department of Pathology and Medical Biology, University Medical Centre Groningen, University of Groningen, Groningen, 9713 GZ, The Netherlands.; Department of Molecular Pharmacology, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, 9713 AV, The Netherlands., Chen T; Department of Molecular Pharmacology, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, 9713 AV, The Netherlands., Xiao Z; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, Groningen, 9713 AV, The Netherlands., Adriana J; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, Groningen, 9713 AV, The Netherlands., Griffith AJ; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, Groningen, 9713 AV, The Netherlands., Gamez AS; Department of Biomedical Sciences of Cell & Systems, Section Molecular Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, 9712 CP, The Netherlands.; Department of Radiation Oncology, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713 GZ, Netherlands., van der Wouden PE; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, Groningen, 9713 AV, The Netherlands., Coppes RP; Department of Biomedical Sciences of Cell & Systems, Section Molecular Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, 9712 CP, The Netherlands.; Department of Radiation Oncology, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713 GZ, Netherlands., Dolga AM; Research School of Behavioural and Cognitive Neuroscience, University of Groningen, Groningen, 9713 AV, The Netherlands.; Department of Molecular Pharmacology, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, 9713 AV, The Netherlands., Haisma HJ; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, Groningen, 9713 AV, The Netherlands., Dekker FJ; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, Groningen, 9713 AV, The Netherlands. |
المصدر: | Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Jun 25, pp. e2403963. Date of Electronic Publication: 2024 Jun 25. |
Publication Model: | Ahead of Print |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Weinheim : WILEY-VCH, [2014]- |
مستخلص: | Ferroptosis is a form of regulated cell death that can be modulated by small molecules and has the potential for the development of therapeutics for oncology. Although excessive lipid peroxidation is the defining hallmark of ferroptosis, DNA damage may also play a significant role. In this study, a potential mechanistic role for MIF in homologous recombination (HR) DNA repair is identified. The inhibition or genetic depletion of MIF or other HR proteins, such as breast cancer type 1 susceptibility protein (BRCA1), is demonstrated to significantly enhance the sensitivity of cells to ferroptosis. The interference with HR results in the translocation of the tumor suppressor protein p53 to the mitochondria, which in turn stimulates the production of reactive oxygen species. Taken together, the findings demonstrate that MIF-directed small molecules enhance ferroptosis via a putative MIF-BRCA1-RAD51 axis in HR, which causes resistance to ferroptosis. This suggests a potential novel druggable route to enhance ferroptosis by targeted anticancer therapeutics in the future. (© 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.) |
References: | S. J. Dixon, K. M. Lemberg, M. R. Lamprecht, R. Skouta, E. M. Zaitsev, C. E. Gleason, D. N. Patel, A. J. Bauer, A. M. Cantley, W. S. Yang, B. Morrison, B. R. Stockwell, Cell 2012, 149, 1060. B. R. Stockwell, J. P. F. Angeli, H. Bayir, A. I. Bush, M. Conrad, S. J. Dixon, S. Fulda, S. Gascon, S. K. Hatzios, V. E. Kagan, K. Noel, X. Jiang, A. Linkermann, M. E. Murphy, M. Overholtzer, A. Oyagi, G. C. Pagnussat, J. Park, Q. Ran, C. S. Rosenfeld, K. Salnikow, D. Tang, F. M. Torti, S. V. Torti, S. Toyokuni, K. A. Woerpel, D. D. Zhang, Cell 2017, 171, 273. N. Majerníková, W. F. A. den Dunnen, A. M. Dolga, Front. Aging Neurosci. 2021, 13, 745046. T. T. Mai, A. Hamaï, A. Hienzsch, T. Cañeque, S. Müller, J. Wicinski, O. Cabaud, C. Leroy, A. David, V. Acevedo, A. Ryo, C. Ginestier, D. Birnbaum, E. Charafe‐Jauffret, P. Codogno, M. Mehrpour, R. Rodriguez, Nat. Chem. 2017, 9, 1025. B. R. Stockwell, Cell 2022, 185, 2401. C. Zhang, X. Liu, S. Jin, Y. Chen, R. Guo, Mol. Cancer 2022, 21, 47. W. S. Yang, R. SriRamaratnam, M. E. Welsch, K. Shimada, R. Skouta, V. S. Viswanathan, J. H. Cheah, P. A. Clemons, A. F. Shamji, C. B. Clish, L. M. Brown, A. W. Girotti, V. W. Cornish, S. L. Schreiber, B. R. Stockwell, Cell 2014, 156, 317. A. Seiler, M. Schneider, H. Förster, S. Roth, E. K. Wirth, C. Culmsee, N. Plesnila, E. Kremmer, O. Rådmark, W. Wurst, G. W. Bornkamm, U. Schweizer, M. Conrad, Cell Metab. 2008, 8, 237. H. Sato, M. Tamba, T. Ishii, S. Bannai, J. Biol. Chem. 1999, 274, 11455. X. Jiang, B. R. Stockwell, M. Conrad, Nat. Rev. Mol. Cell Biol. 2021, 22, 266. E. Mishima, J. Ito, Z. Wu, T. Nakamura, A. Wahida, S. Doll, W. Tonnus, P. Nepachalovich, E. Eggenhofer, M. Aldrovandi, B. Henkelmann, K.‐I. Yamada, J. Wanninger, O. Zilka, E. Sato, R. Feederle, D. Hass, A. Maida, A. S. D. Mourão, A. Linkermann, E. K. Geissler, K. Nakagawa, T. Abe, M. Fedorova, B. Proneth, D. A. Pratt, M. Conrad, Nature 2022, 608, 778. S. Doll, F. P. Freitas, R. Shah, M. Aldrovandi, M. C. da Silva, I. Ingold, A. Goya Grocin, T. N. Xavier da Silva, E. Panzilius, C. H. Scheel, A. Mourão, K. Buday, M. Sato, J. Wanninger, T. Vignane, V. Mohana, M. Rehberg, A. Flatley, A. Schepers, A. Kurz, D. White, M. Sauer, M. Sattler, E. W. Tate, W. Schmitz, A. Schulze, V. O'Donnell, B. Proneth, G. M. Popowicz, D. A. Pratt, et al., Nature 2019, 575, 693. K. Bersuker, J. M. Hendricks, Z. Li, L. Magtanong, B. Ford, P. H. Tang, M. A. Roberts, B. Tong, T. J. Maimone, R. Zoncu, M. C. Bassik, D. K. Nomura, S. J. Dixon, J. A. Olzmann, Nature 2019, 575, 688. V. A. N. Kraft, C. T. Bezjian, S. Pfeiffer, L. Ringelstetter, C. Müller, F. Zandkarimi, J. Merl‐Pham, X. Bao, N. Anastasov, J. Kössl, S. Brandner, J. D. Daniels, P. Schmitt‐Kopplin, S. M. Hauck, B. R. Stockwell, K. Hadian, J. A. Schick, ACS Cent. Sci. 2020, 6, 41. H. J. H. Fenton, J. Chem. Society 1894, 65, 899. E. S. Henle, S. Linn, J. Biol. Chem. 1997, 272, 19095. S. Toyokuni, J.‐L. Sagripanti, Free Radic. Biol. Med. 1993, 15, 117. M. Gao, P. Monian, Q. Pan, W. Zhang, J. Xiang, X. Jiang, Cell Res. 2016, 26, 1021. X. Chen, C. Yu, R. Kang, D. Tang, Front Cell. Dev. Biol. 2020, 8, 590226. L. Krejci, V. Altmannova, M. Spirek, X. Zhao, Nucleic Acids Res. 2012, 40, 5795. S. Burma, B. P. C. Chen, D. J. Chen, DNA Repair (Amst) 2006, 5, 1042. S. F. Bunting, E. Callén, N. Wong, H.‐T. Chen, F. Polato, A. Gunn, A. Bothmer, N. Feldhahn, O. Fernandez‐Capetillo, L. Cao, X. Xu, C.‐X. Deng, T. Finkel, M. Nussenzweig, J. M. Stark, A. Nussenzweig, Cell 2010, 141, 243. A. Bothmer, D. F. Robbiani, N. Feldhahn, A. Gazumyan, A. Nussenzweig, M. C. Nussenzweig, J. Exp. Med. 2010, 207, 855. N. Adachi, T. Ishino, Y. Ishii, S. Takeda, H. Koyama, Proc. Natl. Acad. Sci. U. S. A. 2001, 98, 12109. N. E. Geacintov, S. Broyde, T. Buterin, H. Naegeli, M. Wu, S. Yan, D. J. Patel, Biopolymers 2002, 65, 202. Y. Wang, R. An, G. K. Umanah, H. Park, K. Nambiar, S. M. Eacker, B. Kim, L. Bao, M. M. Harraz, C. Hang, R. Chen, J. E. Wan, T.‐I. Kam, J. S. Jeong, Z. Xie, S. Neifert, J. Qian, S. A. Andrabi, S. Blackshaw, H. Zhu, H. Song, G.‐L. Ming, V. L. Dawson, T. M. Dawson, Science 2016, 354, 1979. Y. Wang, Y. Chen, C. Wang, M. Yang, Y. Wang, L. Bao, J. E. Wang, B. Kim, K. Y. Chan, W. Xu, E. Capota, J. Ortega, D. Nijhawan, G.‐M. Li, W. Luo, Y. Wang, Nat. Commun. 2021, 12, 2954 . H. Park, T. I. Kam, H. Peng, S. C. Chou, A. A. Mehrabani‐Tabari, J. J. Song, X. Yin, S. S. Karuppagounder, G. K. Umanah, A. V. Subba Rao, Y. R. Choi, A. Aggarwal, S. Chang, H. Kim, J. Byun, J. O. Liu, T. M. Dawson, V. L. Dawson, Cell 2022, 185, 1943. A. Shibata, D. Moiani, A. S. Arvai, J. Perry, S. M. Harding, M.‐M. Genois, R. Maity, S. van Rossum‐Fikkert, A. Kertokalio, F. Romoli, A. Ismail, E. Ismalaj, E. Petricci, M. J. Neale, R. G. Bristow, J.‐Y. Masson, C. Wyman, P. A. Jeggo, J. A. Tainer, Mol. Cell 2014, 53, 7. T. T. Paull, M. Gellert, Mol. Cell 1998, 1, 969. E. F. Morand, M. Leech, J. M. Bernhagen, Nat. Rev. Drug Discovery 2006, 5, 399. O. Zilka, R. Shah, B. Li, J. P. Friedmann Angeli, M. Griesser, M. Conrad, D. A. Pratt, ACS Cent. Sci. 2017, 3, 232. J. Periasamy, V. Kurdekar, S. Jasti, M. B. Nijaguna, S. Boggaram, M. A. Hurakadli, D. Raina, L. M. Kurup, C. Chintha, K. Manjunath, A. Goyal, G. Sadasivam, K. Bharatham, M. Padigaru, V. Potluri, A. R. Venkitaraman, Cell Chem. Biol. 2018, 25, 677. F. Huang, O. M. Mazina, I. J. Zentner, S. Cocklin, A. V. Mazin, J. Med. Chem. 2012, 55, 3011. U. Ray, S. K. Raul, V. K. Gopinatha, D. Ghosh, K. S. Rangappa, K. Mantelingu, S. C. Raghavan, Mol. Carcinog. 2020, 59, 618. Y. Sun, H. Lu, X. Fang, S. Xiao, F. Yang, Y. Chen, H. Wang, X. Li, J. Lu, H. Lin, C. Luo, K. Zhao, S. Chen, Bioorg. Med. Chem. 2021, 34, 116054. Z. Xiao, S. Song, D. Chen, R. van Merkerk, P. E. van der Wouden, R. H. Cool, W. J. Quax, G. J. Poelarends, B. N. Melgert, F. J. Dekker, Angew. Chem. – Int. Ed. 2021, 60, 17514. T. Maruyama, S. K. Dougan, M. C. Truttmann, A. M. Bilate, J. R. Ingram, H. L. Ploegh, Nat. Biotechnol. 2015, 33, 538. V. T. Chu, T. Weber, B. Wefers, W. Wurst, S. Sander, K. Rajewsky, R. Kühn, Nat. Biotechnol. 2015, 33, 543. M. D. Canny, N. Moatti, L. C. K. Wan, A. Fradet‐Turcotte, D. Krasner, P. A. Mateos‐Gomez, M. Zimmermann, A. Orthwein, Y.‐C. Juang, W. Zhang, S. M. Noordermeer, E. Seclen, M. D. Wilson, A. Vorobyov, M. Munro, A. Ernst, T. F. Ng, T. Cho, P. M. Cannon, S. S. Sidhu, F. Sicheri, D. Durocher, Nat. Biotechnol. 2018, 36, 95. Z. Xiao, D. Chen, S. Song, R. van der Vlag, P. E. van der Wouden, R. van Merkerk, R. H. Cool, A. K. H. Hirsch, B. N. Melgert, W. J. Quax, G. J. Poelarends, F. J. Dekker, J. Med. Chem. 2020, 63, 11920. S. Madhusudan, F. Smart, P. Shrimpton, J. L. Parsons, L. Gardiner, S. Houlbrook, D. C. Talbot, T. Hammonds, P. A. Freemont, M. J. E. Sternberg, G. L. Dianov, I. D. Hickson, Nucleic Acids Res. 2005, 33, 4711. M. Kawasaki, K. Kuwano, N. Hagimoto, T. Matsuba, R. Kunitake, T. Tanaka, T. Maeyama, N. Hara, Am J Pathol 2000, 157, 597. A. Degterev, Z. Huang, M. Boyce, Y. Li, P. Jagtap, N. Mizushima, G. D. Cuny, T. J. Mitchison, M. A. Moskowitz, J. Yuan, Nat. Chem. Biol. 2005, 1, 112. J. Hu, J. D. Lieb, A. Sancar, S. Adar, Proc. Natl. Acad. Sci. U. S. A. 2016, 113, 11507. O. Tacar, P. Sriamornsak, C. R. Dass, J. Pharm. Pharmacol. 2013, 65, 157. J. Lu, Y. Qian, M. Altieri, H. Dong, J. Wang, K. Raina, J. Hines, J. D. Winkler, A. P. Crew, K. Coleman, C. M. Crews, Chem. Biol. 2015, 22, 755. G. M. Burslem, A. R. Schultz, D. P. Bondeson, C. A. Eide, S. L. Savage Stevens, B. J. Druker, C. M. Crews, Cancer Res. 2019, 79, 4744. G. P. C. Drummen, L. C. M. Van Liebergen, J. A. F. Op den Kamp, J. A. Post, Free Radic. Biol. Med. 2002, 33, 473. N. Musheshe, A. Oun, A. M. Sabogal‐Guaqueta, M. Trombetta‐Lima, S. C. Mitchel, A. Adzemovic, O. Speek, F. Morra, C. H. J. T. van der Veen, F. Lezoualc'h, X. Cheng, M. Schmidt, A. M. Dolga, Antioxidants 2022, 11, 314. I. R. Boldogh, L. A. Pon, Trends Cell Biol. 2007, 17, 502. Z. Zhang, M. Guo, M. Shen, D. Kong, F. Zhang, J. Shao, S. Tan, S. Wang, A. Chen, P. Cao, S. Zheng, Redox Biol. 2020, 36, 101619. J. M. Janssen, X. Chen, J. Liu, M. A. F. V. Gonçalves, Mol. Ther. Nucl. Acids 2019, 16, 141. D. Chen, A. Osipyan, J. Adriana, M. Kader, M. Gureev, C. W. J. Knol, M.‐C. Sigmund, Z. Xiao, P. E. van der Wouden, R. H. Cool, G. J. Poelarends, F. J. Dekker, J. Med. Chem. 2023, 13, 8767. C. Mao, X. Liu, Y. Zhang, G. Lei, Y. Yan, H. Lee, P. Koppula, S. Wu, L. Zhuang, B. Fang, M. V. Poyurovsky, K. Olszewski, B. Gan, Nature 2021, 593, 586. K. Keyer, J. A. Imlay, Proc. Natl. Acad. Sci. U.S. A. 1996, 93, 13635. E. Park, S. W. Chung, Cell Death Dis. 2019, 10, 822. S. Chen, D. Chen, B. Liu, H. J. Haisma, Drug Discov. Today 2022, 27, 951. C. D. Yeh, C. D. Richardson, J. E. Corn, Nat. Cell Biol. 2019, 21, 1468. S. Toyokuni, J. L. Sagripanti, J. Inorg. Biochem. 1992, 47, 241. Y. Xie, W. Hou, X. Song, Y. Yu, J. Huang, X. Sun, R. Kang, D. Tang, Cell Death Differ. 2016, 23, 369. N. Tung, J. E. Garber, npj Breast Cancer 2022, 8, 47. A.‐R. Hartman, R. R. Kaldate, L. M. Sailer, L. Painter, C. E. Grier, R. R. Endsley, M. Griffin, S. A. Hamilton, C. A. Frye, M. A. Silberman, R. J. Wenstrup, J. F. Sandbach, Cancer 2012, 118, 2787. A. Osipyan, D. Chen, F. J. Dekker, Drug Discov. Today 2021, 26, 1728. Z. Xiao, M. Fokkens, D. Chen, T. Kok, G. Proietti, R. van Merkerk, G. J. Poelarends, F. J. Dekker, Eur. J. Med. Chem. 2020, 186, 111849. G. Pantouris, M. A. Syed, C. Fan, D. Rajasekaran, T. Y. Cho, E. M. Rosenberg, R. Bucala, V. Bhandari, E. J. Lolis, Chem. Biol. 2015, 22, 1197. J. Bernhagen, R. Krohn, H. Lue, J. L. Gregory, A. Zernecke, R. R. Koenen, M. Dewor, I. Georgiev, A. Schober, L. Leng, T. Kooistra, G. Fingerle‐Rowson, P. Ghezzi, R. Kleemann, S. R. McColl, R. Bucala, M. J. Hickey, C. Weber, Nat. Med. 2007, 13, 587. R. C. Lynch, J. C. Bendell, R. H. Advani, G. S. Falchook, P. N Munster, M. R. Patel, M. Gutierrez, M. L. Burness, N. Palmisiano, M. Hamadani, W. D. Bradley, T. J. O'Shea, S. Doleman, M. F. Renschler, J. M. Englert, T. A. Yap, J. Clin. Oncol. 2021, 39, 3006. R. C. Lynch, P. N. Munster, G. S. Falchook, M. L. Burness, T. A. Yap, G. Shapiro, D. R. Spigel, M. R. Patel, K. N. Moore, D. Juric, S. Doleman, W. D. Bradley, T. J. O'Shea, J. M. Englert, M. F. Renschler, N. Beri, J. Clin. Oncol. 2023, 41, 3099. |
معلومات مُعتمدة: | 201907720019 China Scholarship Council; 202006220019 China Scholarship Council; 202107060008 China Scholarship Council; OCENW.M.21.213 Nederlandse Organisatie voor Wetenschappelijk Onderzoek; 40-00506-98-9021 Nederlandse Organisatie voor Wetenschappelijk Onderzoek; 175-010-2009-023 Nederlandse Organisatie voor Wetenschappelijk Onderzoek |
فهرسة مساهمة: | Keywords: DNA repair; ferroptosis; homologous recombination; inhibitor; macrophage migration inhibitory factor (MIF) |
تواريخ الأحداث: | Date Created: 20240626 Latest Revision: 20240626 |
رمز التحديث: | 20240627 |
DOI: | 10.1002/advs.202403963 |
PMID: | 38924362 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2198-3844 |
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DOI: | 10.1002/advs.202403963 |