دورية أكاديمية
Polystyrene Nanoplastics Induce Lipid Metabolism Disorder by Activating the PERK-ATF4 Signaling Pathway in Mice.
| العنوان: | Polystyrene Nanoplastics Induce Lipid Metabolism Disorder by Activating the PERK-ATF4 Signaling Pathway in Mice. |
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| المؤلفون: | Yu Z; School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China., Fan X; School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China., Zhao X; School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China., He T; School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China., Li X; School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China., Du H; School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China., Zhao M; School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China., Zhu R; School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China., Li M; School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China., Zhang Z; School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China., Han F; School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China. |
| المصدر: | ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2024 Jul 10; Vol. 16 (27), pp. 34524-34537. Date of Electronic Publication: 2024 Jun 26. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-8252 (Electronic) Linking ISSN: 19448244 NLM ISO Abbreviation: ACS Appl Mater Interfaces Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, D.C. : American Chemical Society |
| مواضيع طبية MeSH: | Polystyrenes*/chemistry , Polystyrenes*/toxicity , Polystyrenes*/pharmacology , Activating Transcription Factor 4*/metabolism , Activating Transcription Factor 4*/genetics , Signal Transduction*/drug effects , eIF-2 Kinase*/metabolism , eIF-2 Kinase*/genetics, Animals ; Mice ; Lipid Metabolism Disorders/metabolism ; Lipid Metabolism Disorders/chemically induced ; Lipid Metabolism Disorders/drug therapy ; Nanoparticles/chemistry ; Nanoparticles/toxicity ; Microplastics/toxicity ; Endoplasmic Reticulum Stress/drug effects ; Lipid Metabolism/drug effects ; Male ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Mice, Inbred C57BL |
| مستخلص: | In recent years, the study of microplastics (MPs) and nanoplastics (NPs) and their effects on human health has gained significant attention. The impacts of NPs on lipid metabolism and the specific mechanisms involved remain poorly understood. To address this, we utilized high-throughput sequencing and molecular biology techniques to investigate how endoplasmic reticulum (ER) stress might affect hepatic lipid metabolism in the presence of polystyrene nanoplastics (PS-NPs). Our findings suggest that PS-NPs activate the PERK-ATF4 signaling pathway, which in turn upregulates the expression of genes related to lipid synthesis via the ATF4-PPARγ/SREBP-1 pathway. This activation leads to an abnormal accumulation of lipid droplets in the liver. 4-PBA, a known ER stress inhibitor, was found to mitigate the PS-NPs-induced lipid metabolism disorder. These results demonstrate the hepatotoxic effects of PS-NPs and clarify the mechanisms of abnormal lipid metabolism induced by PS-NPs. |
| فهرسة مساهمة: | Keywords: PERK-ATF4; endoplasmic reticulum stress; lipid metabolism; lipid synthesis; polystyrene nanoplastics |
| المشرفين على المادة: | 0 (Polystyrenes) 145891-90-3 (Activating Transcription Factor 4) EC 2.7.11.1 (eIF-2 Kinase) EC 2.7.11.1 (PERK kinase) 0 (Atf4 protein, mouse) 0 (Microplastics) |
| تواريخ الأحداث: | Date Created: 20240626 Date Completed: 20240711 Latest Revision: 20240802 |
| رمز التحديث: | 20240802 |
| DOI: | 10.1021/acsami.4c04416 |
| PMID: | 38926154 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1944-8252 |
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| DOI: | 10.1021/acsami.4c04416 |