دورية أكاديمية
Uncovering 2-D toroidal representations in grid cell ensemble activity during 1-D behavior.
| العنوان: | Uncovering 2-D toroidal representations in grid cell ensemble activity during 1-D behavior. |
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| المؤلفون: | Hermansen E; Department of Mathematical Sciences, NTNU, Trondheim, Norway. erik.hermansen@ntnu.no., Klindt DA; Department of Mathematical Sciences, NTNU, Trondheim, Norway.; Cold Spring Harbor Laboratory, Cold Spring Harbor, Laurel Hollow, New York, USA., Dunn BA; Department of Mathematical Sciences, NTNU, Trondheim, Norway. benjamin.dunn@ntnu.no. |
| المصدر: | Nature communications [Nat Commun] 2024 Jun 26; Vol. 15 (1), pp. 5429. Date of Electronic Publication: 2024 Jun 26. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : Nature Pub. Group |
| مواضيع طبية MeSH: | Grid Cells*/physiology, Animals ; Behavior, Animal/physiology ; Male ; Neurons/physiology ; Mice ; Models, Neurological ; Virtual Reality |
| مستخلص: | Minimal experiments, such as head-fixed wheel-running and sleep, offer experimental advantages but restrict the amount of observable behavior, making it difficult to classify functional cell types. Arguably, the grid cell, and its striking periodicity, would not have been discovered without the perspective provided by free behavior in an open environment. Here, we show that by shifting the focus from single neurons to populations, we change the minimal experimental complexity required. We identify grid cell modules and show that the activity covers a similar, stable toroidal state space during wheel running as in open field foraging. Trajectories on grid cell tori correspond to single trial runs in virtual reality and path integration in the dark, and the alignment of the representation rapidly shifts with changes in experimental conditions. Thus, we provide a methodology to discover and study complex internal representations in even the simplest of experiments. (© 2024. The Author(s).) |
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| معلومات مُعتمدة: | 325114 Norges Forskningsråd (Research Council of Norway) |
| تواريخ الأحداث: | Date Created: 20240626 Date Completed: 20240626 Latest Revision: 20240629 |
| رمز التحديث: | 20240629 |
| مُعرف محوري في PubMed: | PMC11208534 |
| DOI: | 10.1038/s41467-024-49703-1 |
| PMID: | 38926360 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2041-1723 |
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| DOI: | 10.1038/s41467-024-49703-1 |