دورية أكاديمية
Stability of ascorbic acid in human aqueous humor.
| العنوان: | Stability of ascorbic acid in human aqueous humor. |
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| المؤلفون: | Ito S; Department of Ophthalmology, Dokkyo Medical University, 880 Kitakobayashi, Shimotsuga-gun, Tochigi, 321-0293, Japan. saka-ito@dokkyomed.ac.jp.; Molecular Regulation of Aging, Tokyo Metropolitan Institute for Geriatrics and Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan. saka-ito@dokkyomed.ac.jp., Nagata M; Department of Ophthalmology, Dokkyo Medical University, 880 Kitakobayashi, Shimotsuga-gun, Tochigi, 321-0293, Japan., Takino Y; Molecular Regulation of Aging, Tokyo Metropolitan Institute for Geriatrics and Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan., Ishigami A; Molecular Regulation of Aging, Tokyo Metropolitan Institute for Geriatrics and Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan., Senoo T; Department of Ophthalmology, Dokkyo Medical University, 880 Kitakobayashi, Shimotsuga-gun, Tochigi, 321-0293, Japan. |
| المصدر: | BMC research notes [BMC Res Notes] 2024 Jun 26; Vol. 17 (1), pp. 179. Date of Electronic Publication: 2024 Jun 26. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Biomed Central Country of Publication: England NLM ID: 101462768 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-0500 (Electronic) Linking ISSN: 17560500 NLM ISO Abbreviation: BMC Res Notes Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Biomed Central, 2008. |
| مواضيع طبية MeSH: | Ascorbic Acid*/chemistry , Aqueous Humor*/chemistry , Aqueous Humor*/metabolism, Humans ; Drug Stability ; Hydrogen-Ion Concentration |
| مستخلص: | Objective: The stability of ascorbic acid (AA) in the human aqueous humor (AqH) remains unclear. This study aimed to investigate the stability of AqH AA under varying conditions (27, 4, - 20, and - 80 °C) without acidification. Results: Rapid AA degradation occurred at 27 °C. At 4 °C, a significant 12.2% degradation was observed after 24 h. Storage at - 20 °C resulted in a notable 37.5% degradation after 28 days, whereas storage at - 80 °C resulted in 10.7% degradation after 28 days. Unacidified AqH samples recorded early decomposition at 27 °C and 4 °C. In conclusion, it is recommended to conduct measurements within 28 days for samples stored at - 80 °C. (© 2024. The Author(s).) |
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| فهرسة مساهمة: | Keywords: Antioxidant; Aqueous humor; Ascorbic acid; High performance liquid chromatography |
| المشرفين على المادة: | PQ6CK8PD0R (Ascorbic Acid) |
| تواريخ الأحداث: | Date Created: 20240626 Date Completed: 20240627 Latest Revision: 20240629 |
| رمز التحديث: | 20240629 |
| مُعرف محوري في PubMed: | PMC11202325 |
| DOI: | 10.1186/s13104-024-06829-1 |
| PMID: | 38926714 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1756-0500 |
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| DOI: | 10.1186/s13104-024-06829-1 |