دورية أكاديمية
Association between maternal age and sex-based neonatal free triiodothyronine levels.
| العنوان: | Association between maternal age and sex-based neonatal free triiodothyronine levels. |
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| المؤلفون: | Chen Y; Obstetrical Department, Women's Hospital School of Medicine Zhejiang University, Hangzhou City, Zhejiang Province, 310006, China., Shen T; Clinical Trial Ward, Women's Hospital School of Medicine Zhejiang University, Hangzhou City, Zhejiang Province, 310006, China., He Y; Department of Obstetrics and Gynecology, Shanghai Jinshan Tinglin Hospital, Shanghai City, 200500, China., Chen X; Obstetrical Department, Women's Hospital School of Medicine Zhejiang University, Hangzhou City, Zhejiang Province, 310006, China., Chen D; Obstetrical Department, Women's Hospital School of Medicine Zhejiang University, Hangzhou City, Zhejiang Province, 310006, China. chendq@zju.edu.cn. |
| المصدر: | BMC endocrine disorders [BMC Endocr Disord] 2024 Jun 27; Vol. 24 (1), pp. 98. Date of Electronic Publication: 2024 Jun 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101088676 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6823 (Electronic) Linking ISSN: 14726823 NLM ISO Abbreviation: BMC Endocr Disord Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BioMed Central, [2001- |
| مواضيع طبية MeSH: | Maternal Age* , Fetal Blood*/chemistry , Fetal Blood*/metabolism , Triiodothyronine*/blood, Humans ; Female ; Adult ; Male ; Pregnancy ; Infant, Newborn ; Sex Factors ; Thyroid Function Tests ; Thyrotropin/blood |
| مستخلص: | Background: Advanced maternal age may affect the intrauterine environment and increase the risk of neurodevelopmental disorders in offspring. Thyroid hormones are critical for fetal neurological development but whether maternal age influences fetal thyroid hormone levels in euthyroid mothers is unknown. Objective: This study evaluated the association between cord blood thyroid hormones and maternal age, fetal sex, maternal thyroid function, and other perinatal factors. Methods: The study population consisted of 203 healthy women with term singleton pregnancies who underwent elective cesarean section. Maternal levels of free T3 (fT3), free T4 (fT4) and TSH before delivery, and cord levels of fT3, fT4 and TSH were measured. Spearman's correlation coefficient and multiple linear regression analyses were performed to determine the correlation between cord thyroid hormone parameters and maternal characteristics. Results: There were no significant differences in maternal serum or cord blood thyroid hormone levels between male and female births. In multivariate linear regression analysis, maternal age and maternal TSH values were negatively associated with the cord blood levels of fT3 in all births, after adjusting for confounding factors. Maternal age was more closely associated with the cord blood levels of fT3 in female than in male births. Conclusion: The inverse association between maternal age and cord blood levels of fT3 in euthyroid pregnant women suggested an impact of maternal aging on offspring thyroid function. (© 2024. The Author(s).) |
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| معلومات مُعتمدة: | LQ20H040003 Natural Science Foundation of Zhejiang Province |
| فهرسة مساهمة: | Keywords: Maternal age; Thyroid hormones; Triiodothyronine |
| المشرفين على المادة: | 06LU7C9H1V (Triiodothyronine) 9002-71-5 (Thyrotropin) |
| تواريخ الأحداث: | Date Created: 20240626 Date Completed: 20240627 Latest Revision: 20240629 |
| رمز التحديث: | 20240629 |
| مُعرف محوري في PubMed: | PMC11209983 |
| DOI: | 10.1186/s12902-024-01631-3 |
| PMID: | 38926806 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1472-6823 |
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| DOI: | 10.1186/s12902-024-01631-3 |