دورية أكاديمية
أعرض في EDS

A Cross-Sectional Exploratory Study of Cardiovascular Risk Biomarkers in Non-Obese Women with and without Polycystic Ovary Syndrome: Association with Vitamin D.

التفاصيل البيبلوغرافية
العنوان: A Cross-Sectional Exploratory Study of Cardiovascular Risk Biomarkers in Non-Obese Women with and without Polycystic Ovary Syndrome: Association with Vitamin D.
المؤلفون: Nandakumar M; Royal College of Surgeons of Ireland, Adliya P.O. Box 15503, Bahrain., Das P; Royal College of Surgeons of Ireland, Adliya P.O. Box 15503, Bahrain., Sathyapalan T; Academic Endocrinology, Diabetes and Metabolism, Hull York Medical School, Hull HU6 7RU, UK., Butler AE; Royal College of Surgeons of Ireland, Adliya P.O. Box 15503, Bahrain., Atkin SL; Royal College of Surgeons of Ireland, Adliya P.O. Box 15503, Bahrain.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Jun 07; Vol. 25 (12). Date of Electronic Publication: 2024 Jun 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Polycystic Ovary Syndrome*/blood , Polycystic Ovary Syndrome*/metabolism , Polycystic Ovary Syndrome*/complications , Biomarkers*/blood , Vitamin D*/blood , Vitamin D*/analogs & derivatives , Cardiovascular Diseases*/etiology , Cardiovascular Diseases*/blood, Humans ; Female ; Adult ; Cross-Sectional Studies ; Heart Disease Risk Factors ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/blood ; Insulin Resistance ; Obesity/complications ; Obesity/blood ; Young Adult
مستخلص: Vitamin D is proposed to have a protective effect against cardiovascular disease, though the mechanism is unclear. Vitamin D deficiency is common in polycystic ovary syndrome (PCOS), where it is strongly related to obesity, insulin resistance (IR) and risk of cardiovascular disease. To determine if the inherent pathophysiology of PCOS or vitamin D levels are linked to dysregulation of cardiovascular risk proteins (CVRPs), a study in non-obese women with PCOS and without IR was undertaken. Our hypothesis was that the levels of vitamin D 3 and its active metabolite would be associated with CVRPs comparably in women with and without PCOS. In women with PCOS ( n = 29) and controls ( n = 29), 54 CVRPs were determined by Slow Off-rate Modified Aptamer (SOMA)-scan plasma protein measurement and correlated to 25-hydroxyvitamin D 3 (25(OH)D 3 ) and the active 1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ) measured by gold standard isotope-dilution liquid chromatography tandem mass spectrometry. Women with PCOS had comparable IR and systemic inflammation (normal C-reactive protein) to control women, though had higher free androgen index and anti-Mullerian hormone levels. 25(OH)D 3 and 1,25(OH) 2 D 3 levels did not differ between groups. Nine CVRPs were higher in PCOS ( p < 0.05) (Galectin-9, Brother of CDO, C-motif chemokine 3, Interleukin-18 receptor-1, Thrombopoietin, Interleukin-1 receptor antagonist protein, Programmed cell death 1 ligand-2, Low-affinity immunoglobulin gamma Fc-region receptor II-b and human growth hormone), whilst 45 CVRPs did not differ. 25(OH)D 3 correlated with five CVRPs in PCOS and one in controls ( p < 0.05). Despite the women with PCOS not exhibiting overt systemic inflammation, 9 of 54 CVRPs were elevated, all relating to inflammation, and 5 of these correlated with 25(OH)D 3, suggesting an ongoing underlying inflammatory process in PCOS even in the absence of obesity/IR.
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فهرسة مساهمة: Keywords: 1,25 dihydroxyvitamin D3; 25 hydroxyvitamin D3; PCOS; biomarkers; cardiovascular risk; polycystic ovary syndrome; vitamin D
المشرفين على المادة: 0 (Biomarkers)
1406-16-2 (Vitamin D)
تواريخ الأحداث: Date Created: 20240627 Date Completed: 20240627 Latest Revision: 20240629
رمز التحديث: 20240629
مُعرف محوري في PubMed: PMC11204004
DOI: 10.3390/ijms25126330
PMID: 38928037
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25126330