دورية أكاديمية
أعرض في EDS

The Lung in Rheumatoid Arthritis-Friend or Enemy?

التفاصيل البيبلوغرافية
العنوان: The Lung in Rheumatoid Arthritis-Friend or Enemy?
المؤلفون: Anton ML; Discipline of Rheumatology, Medical Department II, University of Medicine and Pharmacy 'Grigore T Popa', 700115 Iasi, Romania.; Clinical Rehabilitation Hospital, 700661 Iasi, Romania., Cardoneanu A; Discipline of Rheumatology, Medical Department II, University of Medicine and Pharmacy 'Grigore T Popa', 700115 Iasi, Romania.; Clinical Rehabilitation Hospital, 700661 Iasi, Romania., Burlui AM; Discipline of Rheumatology, Medical Department II, University of Medicine and Pharmacy 'Grigore T Popa', 700115 Iasi, Romania.; Clinical Rehabilitation Hospital, 700661 Iasi, Romania., Mihai IR; Discipline of Rheumatology, Medical Department II, University of Medicine and Pharmacy 'Grigore T Popa', 700115 Iasi, Romania.; Clinical Rehabilitation Hospital, 700661 Iasi, Romania., Richter P; Discipline of Rheumatology, Medical Department II, University of Medicine and Pharmacy 'Grigore T Popa', 700115 Iasi, Romania.; Clinical Rehabilitation Hospital, 700661 Iasi, Romania., Bratoiu I; Discipline of Rheumatology, Medical Department II, University of Medicine and Pharmacy 'Grigore T Popa', 700115 Iasi, Romania.; Clinical Rehabilitation Hospital, 700661 Iasi, Romania., Macovei LA; Discipline of Rheumatology, Medical Department II, University of Medicine and Pharmacy 'Grigore T Popa', 700115 Iasi, Romania.; Clinical Rehabilitation Hospital, 700661 Iasi, Romania., Rezus E; Discipline of Rheumatology, Medical Department II, University of Medicine and Pharmacy 'Grigore T Popa', 700115 Iasi, Romania.; Clinical Rehabilitation Hospital, 700661 Iasi, Romania.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Jun 12; Vol. 25 (12). Date of Electronic Publication: 2024 Jun 12.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Arthritis, Rheumatoid*/metabolism , Arthritis, Rheumatoid*/immunology , Arthritis, Rheumatoid*/pathology , Arthritis, Rheumatoid*/etiology , Lung Diseases, Interstitial*/etiology , Lung Diseases, Interstitial*/immunology , Lung Diseases, Interstitial*/metabolism , Lung Diseases, Interstitial*/pathology, Humans ; Lung/pathology ; Lung/immunology ; Lung/metabolism ; Animals ; Autoantibodies/immunology
مستخلص: Rheumatoid arthritis (RA) is a chronic autoimmune condition frequently found in rheumatological patients that sometimes raises diagnosis and management problems. The pathogenesis of the disease is complex and involves the activation of many cells and intracellular signaling pathways, ultimately leading to the activation of the innate and acquired immune system and producing extensive tissue damage. Along with joint involvement, RA can have numerous extra-articular manifestations (EAMs), among which lung damage, especially interstitial lung disease (ILD), negatively influences the evolution and survival of these patients. Although there are more and more RA-ILD cases, the pathogenesis is incompletely understood. In terms of genetic predisposition, external environmental factors act and subsequently determine the activation of immune system cells such as macrophages, neutrophils, B and T lymphocytes, fibroblasts, and dendritic cells. These, in turn, show the ability to secrete molecules with a proinflammatory role (cytokines, chemokines, growth factors) that will produce important visceral injuries, including pulmonary changes. Currently, there is new evidence that supports the initiation of the systemic immune response at the level of pulmonary mucosa where the citrullination process occurs, whereby the autoantibodies subsequently migrate from the lung to the synovial membrane. The aim of this paper is to provide current data regarding the pathogenesis of RA-associated ILD, starting from environmental triggers and reaching the cellular, humoral, and molecular changes involved in the onset of the disease.
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فهرسة مساهمة: Keywords: ACPA; RA-ILD; cytokines; interstitial lung disease; lung; pathogenesis; rheumatoid arthritis
المشرفين على المادة: 0 (Autoantibodies)
تواريخ الأحداث: Date Created: 20240627 Date Completed: 20240627 Latest Revision: 20240629
رمز التحديث: 20240629
مُعرف محوري في PubMed: PMC11203675
DOI: 10.3390/ijms25126460
PMID: 38928165
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25126460