دورية أكاديمية
أعرض في EDS

Predicted Brain Age in First-Episode Psychosis: Association with Inexpressivity.

التفاصيل البيبلوغرافية
العنوان: Predicted Brain Age in First-Episode Psychosis: Association with Inexpressivity.
المؤلفون: Salisbury DF; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA., Wulf BM; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA., Seebold D; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA., Coffman BA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA., Curtis MT; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA., Karim HT; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, USA.
المصدر: Brain sciences [Brain Sci] 2024 May 24; Vol. 14 (6). Date of Electronic Publication: 2024 May 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101598646 Publication Model: Electronic Cited Medium: Print ISSN: 2076-3425 (Print) Linking ISSN: 20763425 NLM ISO Abbreviation: Brain Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مستخلص: Accelerated brain aging is a possible mechanism of pathology in schizophrenia. Advances in MRI-based brain development algorithms allow for the calculation of predicted brain age (PBA) for individuals. Here, we assessed PBA in 70 first-episode schizophrenia-spectrum individuals (FESz) and 76 matched healthy neurotypical comparison individuals (HC) to determine if FESz showed advanced aging proximal to psychosis onset and whether PBA was associated with neurocognitive, social functioning, or symptom severity measures. PBA was calculated with BrainAgeR (v2.1) from T1-weighted MR scans. There were no differences in the PBAs between groups. After controlling for actual age, a "younger" PBA was associated with higher vocabulary scores among all individuals, while an "older" PBA was associated with more severe negative symptom "Inexpressivity" component scores among FESz. Female participants in both groups had an elevated PBA relative to male participants. These results suggest that a relatively younger brain age is associated with a better semantic memory performance. There is no evidence for accelerated aging in FESz with a late adolescent/early adult onset. Despite a normative PBA, FESz with a greater residual PBA showed impairments in a cluster of negative symptoms, which may indicate some underlying age-related pathology proximal to psychosis onset. Although a period of accelerated aging cannot be ruled out with disease course, it does not occur at the time of the first episode.
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معلومات مُعتمدة: P50 MH103204 United States GF NIH HHS; R01 MH108568 United States GF NIH HHS
فهرسة مساهمة: Keywords: brain age; cognitive function; first-episode psychosis; schizophrenia
تواريخ الأحداث: Date Created: 20240627 Latest Revision: 20240629
رمز التحديث: 20240629
مُعرف محوري في PubMed: PMC11201938
DOI: 10.3390/brainsci14060532
PMID: 38928532
قاعدة البيانات: MEDLINE
الوصف
تدمد:2076-3425
DOI:10.3390/brainsci14060532