دورية أكاديمية
أعرض في EDS

Antimicrobial and Anesthetic Niosomal Formulations Based on Amino Acid-Derived Surfactants.

التفاصيل البيبلوغرافية
العنوان: Antimicrobial and Anesthetic Niosomal Formulations Based on Amino Acid-Derived Surfactants.
المؤلفون: Romeo M; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Arcavacata di Rende, Italy., Hafidi Z; Department of Surfactants and Nanobiotechnology, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), 08034 Barcelona, Spain., Muzzalupo R; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Arcavacata di Rende, Italy., Pons R; Department of Surfactants and Nanobiotechnology, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), 08034 Barcelona, Spain., García MT; Department of Surfactants and Nanobiotechnology, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), 08034 Barcelona, Spain., Mazzotta E; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Arcavacata di Rende, Italy., Pérez L; Department of Surfactants and Nanobiotechnology, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), 08034 Barcelona, Spain.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2024 Jun 14; Vol. 29 (12). Date of Electronic Publication: 2024 Jun 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Liposomes*/chemistry , Surface-Active Agents*/chemistry , Surface-Active Agents*/pharmacology, Amino Acids/chemistry ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/pharmacology ; Molecular Docking Simulation ; Anesthetics/chemistry ; Anesthetics/pharmacology ; Drug Compounding ; Microbial Sensitivity Tests
مستخلص: Background: This work proposes the development of new vesicular systems based on anesthetic compounds (lidocaine (LID) and capsaicin (CA)) and antimicrobial agents (amino acid-based surfactants from phenylalanine), with a focus on physicochemical characterization and the evaluation of antimicrobial and cytotoxic properties.
Method: Phenylalanine surfactants were characterized via high-performance liquid chromatography (HPLC) and nuclear magnetic resonance (NMR). Different niosomal systems based on capsaicin, lidocaine, cationic phenylalanine surfactants, and dipalmitoyl phosphatidylcholine (DPPC) were characterized in terms of size, polydispersion index (PI), zeta potential, and encapsulation efficiency using dynamic light scattering (DLS), transmitted light microscopy (TEM), and small-angle X-ray scattering (SAXS). Furthermore, the interaction of the pure compounds used to prepare the niosomal formulations with DPPC monolayers was determined using a Langmuir balance. The antibacterial activity of the vesicular systems and their biocompatibility were evaluated, and molecular docking studies were carried out to obtain information about the mechanism by which these compounds interact with bacteria.
Results: The stability and reduced size of the analyzed niosomal formulations demonstrate their potential in pharmaceutical applications. The nanosystems exhibit promising antimicrobial activity, marking a significant advancement in pharmaceutical delivery systems with dual therapeutic properties. The biocompatibility of some formulations underscores their viability.
Conclusions: The proposed niosomal formulations could constitute an important advance in the pharmaceutical field, offering delivery systems for combined therapies thanks to the pharmacological properties of the individual components.
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معلومات مُعتمدة: PID2022-136354-NBI00, 2020ENLMHA_002 MCIN/AEI/10.13039/501100011033 , PRIN (Progetti di Rilevante Interesse Nazionale
فهرسة مساهمة: Keywords: amino acid-based surfactant; antimicrobial activity; niosome; phenylalanine
المشرفين على المادة: 0 (Liposomes)
0 (Surface-Active Agents)
0 (Amino Acids)
0 (Anti-Infective Agents)
0 (Anesthetics)
تواريخ الأحداث: Date Created: 20240627 Date Completed: 20240627 Latest Revision: 20240629
رمز التحديث: 20240629
مُعرف محوري في PubMed: PMC11206639
DOI: 10.3390/molecules29122843
PMID: 38930908
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules29122843