دورية أكاديمية
أعرض في EDS

Chemical Composition, Antioxidant, and Cytotoxic Activity of Essential Oils in the Above-Ground Parts of Sonchus oleraceus L.

التفاصيل البيبلوغرافية
العنوان: Chemical Composition, Antioxidant, and Cytotoxic Activity of Essential Oils in the Above-Ground Parts of Sonchus oleraceus L.
المؤلفون: El Gendy AEG; Medicinal and Aromatic Plants Research Department, National Research Centre, Giza 12622, Egypt., Mohamed NA; Medical Biochemistry Department, National Research Centre, Cairo 12622, Egypt., Sarker TC; Texs A&M AgriLife Research Center, Overton, TX 75684, USA., Hassan EM; Medicinal and Aromatic Plants Research Department, National Research Centre, Giza 12622, Egypt., Garaa AH; Department of Natural Compounds Chemistry, National Research Centre, Giza 12622, Egypt., Elshamy AI; Medicinal and Aromatic Plants Research Department, National Research Centre, Giza 12622, Egypt., Abd-ElGawad AM; Plant Production Department, College of Food & Agriculture Sciences, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi Arabia.
المصدر: Plants (Basel, Switzerland) [Plants (Basel)] 2024 Jun 20; Vol. 13 (12). Date of Electronic Publication: 2024 Jun 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101596181 Publication Model: Electronic Cited Medium: Print ISSN: 2223-7747 (Print) Linking ISSN: 22237747 NLM ISO Abbreviation: Plants (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2012]-
مستخلص: Sonchus oleraceus L. is a leafy vegetable that is usually consumed in the area of the Mediterranean and is a frequently used traditional herb to treat a variety of ailments. Previous studies deduced the potent antioxidant and cytotoxic functions of the different extracts and isolated compounds from S. oleraceus . The current study represents the first instance of chemical profiling and bioactivities of the extracted essential oil (EO) of S. oleraceus . The present investigation set out to identify the chemical components of this EO by means of Gas Chromatography with Flame Ionization Detector (GC-FID) and Gas Chromatography-Mass Spectrometry (G004-MS) techniques; assess the oil's antioxidant potencies through 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonate (ABTS) assays; and evaluate the oil's cytotoxic impact against HepG2 cancer cell lines. The GC-MS chemical profiling revealed the identification of 23 components representing 97.43% of the total oil mass within abundant cyclic ketones (20.15%), nonterpenoidial hydrocarbons (28.77%), and sesquiterpenes (42.19%). The main components were n -nonadecane (28.77%), trans -caryophyllene (23.73%), trans -methyl dihydrojasmonate (19.55%), and cis -cadina-1,4-diene (9.44%). In a dose-dependent manner, this EO demonstrated antioxidant capacities on DPPH and ABTS, with IC 50 values of 609.35 and 804.16 µg/mL, respectively, compared to ascorbic acid. Using doxorubicin as a reference therapy, the MTT assay findings revealed that this oil had remarkable inhibitory effects on the proliferation of HepG2 cancer cell lines, with an IC 50 of 136.02 µg/mL. More studies were recommended for further investigation of new biological roles for this oil and its main components, along with the construction of action mechanisms based on chemical components.
References: EXCLI J. 2014 May 13;13:526-35. (PMID: 26417280)
J Agric Food Chem. 2013 Nov 20;61(46):10835-47. (PMID: 24156356)
Nat Prod Commun. 2010 Feb;5(2):319-28. (PMID: 20334152)
J Immunol Methods. 1983 Dec 16;65(1-2):55-63. (PMID: 6606682)
Prikl Biokhim Mikrobiol. 2009 Nov-Dec;45(6):710-6. (PMID: 20067158)
Nat Prod Commun. 2014 Jul;9(7):1003-6. (PMID: 25230514)
Oxid Med Cell Longev. 2022 Feb 3;2022:9004014. (PMID: 35154574)
J Physiol Pharmacol. 2005 Mar;56 Suppl 1:115-24. (PMID: 15800389)
Nat Prod Commun. 2009 Mar;4(3):405-10. (PMID: 19413122)
Molecules. 2019 Aug 15;24(16):. (PMID: 31443182)
Molecules. 2015 Jun 26;20(7):11808-29. (PMID: 26132906)
Eur J Pharmacol. 2014 Oct 5;740:364-78. (PMID: 25058905)
Nat Prod Res. 2013;27(1):68-71. (PMID: 22273350)
Plants (Basel). 2021 Nov 03;10(11):. (PMID: 34834729)
Int J Mol Sci. 2021 Mar 16;22(6):. (PMID: 33809449)
Molecules. 2015 Apr 17;20(4):7034-47. (PMID: 25898416)
Cancer Med. 2016 Oct;5(10):3007-3017. (PMID: 27696789)
Pharm Biol. 2015 May;53(5):746-51. (PMID: 25339240)
Molecules. 2020 Oct 14;25(20):. (PMID: 33066611)
Biomarkers. 2022 May;27(3):247-257. (PMID: 34978233)
Free Radic Biol Med. 1999 May;26(9-10):1231-7. (PMID: 10381194)
BMC Complement Altern Med. 2013 Jul 15;13:175. (PMID: 23855679)
Molecules. 2022 Oct 10;27(19):. (PMID: 36235309)
Nat Prod Commun. 2012 Nov;7(11):1527-30. (PMID: 23285823)
J Oleo Sci. 2021;70(11):1669-1676. (PMID: 34732637)
Antioxidants (Basel). 2021 Jul 05;10(7):. (PMID: 34356313)
Molecules. 2010 Dec 15;15(12):9252-87. (PMID: 21160452)
Heliyon. 2020 Mar 31;6(3):e03683. (PMID: 32258501)
Pharm Biol. 2017 Dec;55(1):799-809. (PMID: 28112016)
Medicines (Basel). 2017 Aug 23;4(3):. (PMID: 28930277)
Molecules. 2008 Sep 02;13(9):2058-68. (PMID: 18830141)
Food Chem Toxicol. 2008 Feb;46(2):446-75. (PMID: 17996351)
Planta Med. 2015 May;81(7):563-7. (PMID: 25856436)
J Ethnopharmacol. 2010 Feb 17;127(3):737-41. (PMID: 19962434)
Antibiotics (Basel). 2021 Mar 03;10(3):. (PMID: 33802470)
Chemosphere. 2018 Feb;193:833-839. (PMID: 29874756)
معلومات مُعتمدة: RSPD2024R676 King Saud University
فهرسة مساهمة: Keywords: Sonchus oleraceus; anticancer; antioxidant; chemical profile; trans-caryophyllene; volatile components
تواريخ الأحداث: Date Created: 20240627 Latest Revision: 20240629
رمز التحديث: 20240629
مُعرف محوري في PubMed: PMC11207314
DOI: 10.3390/plants13121712
PMID: 38931144
قاعدة البيانات: MEDLINE
الوصف
تدمد:2223-7747
DOI:10.3390/plants13121712