دورية أكاديمية
أعرض في EDS

Low-Iron Diet-Induced Fatty Liver Development Is Microbiota Dependent and Exacerbated by Loss of the Mitochondrial Iron Importer Mitoferrin2.

التفاصيل البيبلوغرافية
العنوان: Low-Iron Diet-Induced Fatty Liver Development Is Microbiota Dependent and Exacerbated by Loss of the Mitochondrial Iron Importer Mitoferrin2.
المؤلفون: Klag KA; Department of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA., Bell R; Department of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA., Jia X; Department of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA., Seguin A; Department of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA., Maschek JA; Metabolomics Core Research Facility, University of Utah, Salt Lake City, UT 84112, USA., Bronner M; Department of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.; Huntsman Cancer Institute, Salt Lake City, UT 84112, USA., Cox JE; Metabolomics Core Research Facility, University of Utah, Salt Lake City, UT 84112, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84132, USA., Round JL; Department of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA., Ward DM; Department of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.
المصدر: Nutrients [Nutrients] 2024 Jun 08; Vol. 16 (12). Date of Electronic Publication: 2024 Jun 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Gastrointestinal Microbiome* , Liver*/metabolism, Animals ; Female ; Male ; Mice ; Fatty Liver/etiology ; Insulin Resistance ; Iron/metabolism ; Iron Deficiencies ; Iron, Dietary/administration & dosage ; Lipid Metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Mitochondria/metabolism ; Mitochondrial Proteins/metabolism ; Triglycerides/blood
مستخلص: Iron deficiency is the number one nutritional problem worldwide. Iron uptake is regulated at the intestine and is highly influenced by the gut microbiome. Blood from the intestines drains directly into the liver, informing iron status and gut microbiota status. Changes in either iron or the microbiome are tightly correlated with the development of metabolic dysfunction-associated steatotic liver disease (MASLD). To investigate the underlying mechanisms of the development of MASLD that connect altered iron metabolism and gut microbiota, we compared specific pathogen free (SPF) or germ-free (GF) mice, fed a normal or low-iron diet. SPF mice on a low-iron diet showed reduced serum triglycerides and MASLD. In contrast, GF low-iron diet-fed mice showed increased serum triglycerides and did not develop hepatic steatosis. SPF mice showed significant changes in liver lipid metabolism and increased insulin resistance that was dependent upon the presence of the gut microbiota. We report that total body loss of mitochondrial iron importer Mitoferrin2 ( Mfrn2 - / - ) exacerbated the development of MASLD on a low-iron diet with significant lipid metabolism alterations. Our study demonstrates a clear contribution of the gut microbiome, dietary iron, and Mfrn2 in the development of MASLD and metabolic syndrome.
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معلومات مُعتمدة: DK052830 United States NH NIH HHS; U54DK110858 United States NH NIH HHS; F30DK127846 United States NH NIH HHS; DK124336 United States NH NIH HHS; DK124317 United States NH NIH HHS; AT011423 United States NH NIH HHS
فهرسة مساهمة: Keywords: iron; lipid; liver metabolism; microbiota; mitochondria
المشرفين على المادة: E1UOL152H7 (Iron)
0 (Iron, Dietary)
0 (Mitochondrial Proteins)
0 (Triglycerides)
0 (Slc25a28 protein, mouse)
تواريخ الأحداث: Date Created: 20240627 Date Completed: 20240627 Latest Revision: 20240704
رمز التحديث: 20240705
مُعرف محوري في PubMed: PMC11206261
DOI: 10.3390/nu16121804
PMID: 38931165
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu16121804