دورية أكاديمية
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Phyto-Photodynamic Therapy of Prostate Cancer Cells Mediated by Yemenite 'Etrog' Leave Extracts.

التفاصيل البيبلوغرافية
العنوان: Phyto-Photodynamic Therapy of Prostate Cancer Cells Mediated by Yemenite 'Etrog' Leave Extracts.
المؤلفون: Hochma E; Department of Physics, Ariel University, Ariel 4070000, Israel.; Department of Chemical Engineering, Ariel University, Ariel 4070000, Israel., Ishai PB; Department of Physics, Ariel University, Ariel 4070000, Israel., Firer MA; Department of Chemical Engineering, Ariel University, Ariel 4070000, Israel.; Adelson School of Medicine, Ariel University, Ariel 4070000, Israel., Minnes R; Department of Physics, Ariel University, Ariel 4070000, Israel.
المصدر: Nutrients [Nutrients] 2024 Jun 10; Vol. 16 (12). Date of Electronic Publication: 2024 Jun 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Plant Extracts*/pharmacology , Photochemotherapy*/methods , Prostatic Neoplasms*/drug therapy , Plant Leaves*/chemistry , Cell Survival*/drug effects, Humans ; Male ; Photosensitizing Agents/pharmacology ; PC-3 Cells ; Reactive Oxygen Species/metabolism ; Yemen ; Cell Line, Tumor ; Antineoplastic Agents, Phytogenic/pharmacology
مستخلص: Cancer therapy, from malignant tumor inhibition to cellular eradication treatment, remains a challenge, especially regarding reduced side effects and low energy consumption during treatment. Hence, phytochemicals as cytotoxic sensitizers or photosensitizers deserve special attention. The dark and photo-response of Yemenite 'Etrog' leaf extracts applied to prostate PC3 cancer cells is reported here. An XTT cell viability assay along with light microscope observations revealed pronounced cytotoxic activity of the extract for long exposure times of 72 h upon concentrations of 175 μg/mL and 87.5 μg/mL, while phototoxic effect was obtained even at low concentration of 10.93 μg/mL and a short introduction period of 1.5 h. For the longest time incubation of 72 h and for the highest extract concentration of 175 μg/mL, relative cell survival decreased by up to 60% (below the IC 50 ). In combined phyto-photodynamic therapy, a reduction of 63% compared to unirradiated controls was obtained. The concentration of extract in cells versus the accumulation time was inversely related to fluorescence emission intensity readings. Extracellular ROS production was also shown. Based on an ATR-FTIR analysis of the powdered leaves and their liquid ethanolic extract, biochemical fingerprints of both polar and non-polar phyto-constituents were identified, thereby suggesting their implementation as phyto-medicine and phyto-photomedicine.
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فهرسة مساهمة: Keywords: Etrog; antioxidants; citron; flavonoids; leaf extracts; oxidative stress; photodynamic therapy; phytochemicals; polyphenolic acids; prostate cancer; reactive oxygen species
المشرفين على المادة: 0 (Plant Extracts)
0 (Photosensitizing Agents)
0 (Reactive Oxygen Species)
0 (Antineoplastic Agents, Phytogenic)
تواريخ الأحداث: Date Created: 20240627 Date Completed: 20240627 Latest Revision: 20240629
رمز التحديث: 20240629
مُعرف محوري في PubMed: PMC11206993
DOI: 10.3390/nu16121820
PMID: 38931175
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu16121820