دورية أكاديمية
أعرض في EDS

Novel Proteome Targets Marking Insulin Resistance in Metabolic Syndrome.

التفاصيل البيبلوغرافية
العنوان: Novel Proteome Targets Marking Insulin Resistance in Metabolic Syndrome.
المؤلفون: Warmbrunn MV; Department of Internal and Vascular Medicine, Amsterdam University Medical Centers, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.; Amsterdam UMC, Gastroenterology and Hepatology, Amsterdam Gastroenterology Endocrinology Metabolism, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.; Amsterdam UMC, Cardiovascular Sciences, Amsterdam Cardiovascular Sciences, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands., Bahrar H; Department of Internal Medicine, Radboud University Medical Center, 6525 EP Nijmegen, The Netherlands., de Clercq NC; Department of Internal and Vascular Medicine, Amsterdam University Medical Centers, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands., Koopen AM; Department of Internal and Vascular Medicine, Amsterdam University Medical Centers, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands., de Groot PF; Department of Internal and Vascular Medicine, Amsterdam University Medical Centers, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands., Rutten J; Department of Internal Medicine, Radboud University Medical Center, 6525 EP Nijmegen, The Netherlands., Joosten LAB; Department of Internal Medicine, Radboud University Medical Center, 6525 EP Nijmegen, The Netherlands., Kootte RS; Department of Internal and Vascular Medicine, Amsterdam University Medical Centers, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands., Bouter KEC; Department of Internal and Vascular Medicine, Amsterdam University Medical Centers, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands., Ter Horst KW; Department of Internal and Vascular Medicine, Amsterdam University Medical Centers, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands., Hartstra AV; Department of Internal and Vascular Medicine, Amsterdam University Medical Centers, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands., Serlie MJ; Department of Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands., Soeters MR; Department of Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands., van Raalte DH; Diabetes Center, Department of Endocrniology and Metabolism, Amsterdam UMC, VU University Medical Centers, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences, VU University, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands., Davids M; Department of Internal and Vascular Medicine, Amsterdam University Medical Centers, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands., Levin E; Department of Internal and Vascular Medicine, Amsterdam University Medical Centers, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands., Herrema H; Department of Internal and Vascular Medicine, Amsterdam University Medical Centers, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands., Riksen NP; Department of Internal Medicine, Radboud University Medical Center, 6525 EP Nijmegen, The Netherlands., Netea MG; Department of Internal Medicine, Radboud University Medical Center, 6525 EP Nijmegen, The Netherlands., Groen AK; Department of Internal and Vascular Medicine, Amsterdam University Medical Centers, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands., Nieuwdorp M; Department of Internal and Vascular Medicine, Amsterdam University Medical Centers, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
المصدر: Nutrients [Nutrients] 2024 Jun 10; Vol. 16 (12). Date of Electronic Publication: 2024 Jun 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Insulin Resistance* , Metabolic Syndrome*/metabolism , Biomarkers*/blood , Proteome*, Humans ; Male ; Female ; Cross-Sectional Studies ; Middle Aged ; Adult ; Glucose Clamp Technique ; Obesity/metabolism ; Adipose Tissue/metabolism ; Insulin/blood ; Insulin/metabolism ; Intra-Abdominal Fat/metabolism
مستخلص: Context/objective: In order to better understand which metabolic differences are related to insulin resistance in metabolic syndrome (MetSyn), we used hyperinsulinemic-euglycemic (HE) clamps in individuals with MetSyn and related peripheral insulin resistance to circulating biomarkers.
Design/methods: In this cross-sectional study, HE-clamps were performed in treatment-naive men (n = 97) with MetSyn. Subjects were defined as insulin-resistant based on the rate of disappearance (Rd). Machine learning models and conventional statistics were used to identify biomarkers of insulin resistance. Findings were replicated in a cohort with n = 282 obese men and women with (n = 156) and without (n = 126) MetSyn. In addition to this, the relation between biomarkers and adipose tissue was assessed by nuclear magnetic resonance imaging.
Results: Peripheral insulin resistance is marked by changes in proteins related to inflammatory processes such as IL-1 and TNF-receptor and superfamily members. These proteins can distinguish between insulin-resistant and insulin-sensitive individuals (AUC = 0.72 ± 0.10) with MetSyn. These proteins were also associated with IFG, liver fat (rho 0.36, p = 1.79 × 10 -9 ) and visceral adipose tissue (rho = 0.35, p = 6.80 × 10 -9 ). Interestingly, these proteins had the strongest association in the MetSyn subgroup compared to individuals without MetSyn.
Conclusions: MetSyn associated with insulin resistance is characterized by protein changes related to body fat content, insulin signaling and pro-inflammatory processes. These findings provide novel targets for intervention studies and should be the focus of future in vitro and in vivo studies.
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معلومات مُعتمدة: 2018-27 Hartstichting; 09150182010020 Netherlands ZONMW_ ZonMw; 2019.82.004 Dutch Diabetes Federation; 432325352 Deutsche Forschungsgemeinschaft; 17CVD01 LeDucq
فهرسة مساهمة: Keywords: Interleukin-1; insulin resistance; obesity; proteomics; tumor necrosis factor
المشرفين على المادة: 0 (Biomarkers)
0 (Proteome)
0 (Insulin)
تواريخ الأحداث: Date Created: 20240627 Date Completed: 20240627 Latest Revision: 20240722
رمز التحديث: 20240722
مُعرف محوري في PubMed: PMC11206392
DOI: 10.3390/nu16121822
PMID: 38931177
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu16121822