دورية أكاديمية
Selenomethionine Inhibited HADV-Induced Apoptosis Mediated by ROS through the JAK-STAT3 Signaling Pathway.
العنوان: | Selenomethionine Inhibited HADV-Induced Apoptosis Mediated by ROS through the JAK-STAT3 Signaling Pathway. |
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المؤلفون: | Li C; Center Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510120, China., Liu X; Center Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510120, China., Li J; Center Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510120, China., Lai J; Center Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510120, China., Su J; Center Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510120, China., Zhu B; Center Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510120, China., Gao B; School of Pharmacy, Fudan University, Shanghai 200437, China., Li Y; Center Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510120, China., Zhao M; Center Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510120, China. |
المصدر: | Nutrients [Nutrients] 2024 Jun 20; Vol. 16 (12). Date of Electronic Publication: 2024 Jun 20. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI Publishing |
مواضيع طبية MeSH: | Apoptosis*/drug effects , Reactive Oxygen Species*/metabolism , Selenomethionine*/pharmacology , Signal Transduction*/drug effects, Humans ; A549 Cells ; Antiviral Agents/pharmacology ; Janus Kinases/metabolism ; Membrane Potential, Mitochondrial/drug effects ; STAT3 Transcription Factor/metabolism |
مستخلص: | Adenovirus (HAdV) can cause severe respiratory infections in children and immunocompromised patients. There is a lack of specific therapeutic drugs for HAdV infection, and the study of anti-adenoviral drugs has far-reaching clinical implications. Elemental selenium can play a specific role as an antioxidant in the human immune cycle by non-specifically binding to the amino acid methionine in body proteins. Methods: The antiviral mechanism of selenomethionine was explored by measuring cell membrane status, intracellular DNA status, cytokine secretion, mitochondrial membrane potential, and ROS production. Conclusions: Selenomethionine improved the regulation of ROS-mediated apoptosis by modulating the expression of Jak1/2, STAT3, and BCL-XL, which led to the inhibition of apoptosis. It is anticipated that selenomethionine will offer a new anti-adenoviral therapeutic alternative. |
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معلومات مُعتمدة: | LMM2020-7 the Open Project of Guangdong Key Laboratory of Marine Materia; 202201020655 and 202102010202 the technology planning projects of Guangzhou; 2020A1515110648 the Guangdong Natural Science Foundation; 2020A03 the Open Fund of Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications; 2022A149, 2022ekky005 and 02-408-2203-2079 the Guangzhou Medical University Students'Science and Technology Innovation Project |
فهرسة مساهمة: | Keywords: ROS; adenovirus; apoptosis; selenomethionine |
المشرفين على المادة: | 0 (Antiviral Agents) EC 2.7.10.2 (Janus Kinases) 0 (Reactive Oxygen Species) 964MRK2PEL (Selenomethionine) 0 (STAT3 protein, human) 0 (STAT3 Transcription Factor) |
تواريخ الأحداث: | Date Created: 20240627 Date Completed: 20240627 Latest Revision: 20240722 |
رمز التحديث: | 20240722 |
مُعرف محوري في PubMed: | PMC11206631 |
DOI: | 10.3390/nu16121966 |
PMID: | 38931321 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2072-6643 |
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DOI: | 10.3390/nu16121966 |