دورية أكاديمية
Clinical Factors Associated with SFTS Diagnosis and Severity in Cats.
العنوان: | Clinical Factors Associated with SFTS Diagnosis and Severity in Cats. |
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المؤلفون: | Osako H; Department of Virology, Institute of Tropical Medicine, Nagasaki University (ITM-NU), Nagasaki 852-8523, Japan.; Medical School, Nagasaki University, Nagasaki 852-8523, Japan., Xu Q; Department of Virology, Institute of Tropical Medicine, Nagasaki University (ITM-NU), Nagasaki 852-8523, Japan.; Program for Nurturing Global Leaders in Tropical and Emerging Communicable Diseases, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan., Nabeshima T; Department of Virology, Institute of Tropical Medicine, Nagasaki University (ITM-NU), Nagasaki 852-8523, Japan., Balingit JC; Department of Virology, Institute of Tropical Medicine, Nagasaki University (ITM-NU), Nagasaki 852-8523, Japan.; DEJIMA Infectious Disease Research Alliance, Nagasaki University, Nagasaki 852-8523, Japan., Nwe KM; Department of Virology, Institute of Tropical Medicine, Nagasaki University (ITM-NU), Nagasaki 852-8523, Japan.; DEJIMA Infectious Disease Research Alliance, Nagasaki University, Nagasaki 852-8523, Japan., Yu F; Department of Central Laboratory, Guizhou Provincial People's Hospital, Guiyang 550002, China.; National Health Commission (NHC) Key Laboratory of Pulmonary Immunological Diseases, Guizhou Provincial People's Hospital, Guiyang 550002, China., Inoue S; Kenya Research Station, Institute of Tropical Medicine, Nagasaki University (ITM-NU), Nagasaki 852-8523, Japan., Hayasaka D; Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi 753-8515, Japan., Ngwe Tun MM; Department of Virology, Institute of Tropical Medicine, Nagasaki University (ITM-NU), Nagasaki 852-8523, Japan.; DEJIMA Infectious Disease Research Alliance, Nagasaki University, Nagasaki 852-8523, Japan.; Center for Vaccines and Therapeutic Antibodies for Emerging Infectious Diseases, Shimane University, Izumo 690-8504, Japan., Morita K; Department of Virology, Institute of Tropical Medicine, Nagasaki University (ITM-NU), Nagasaki 852-8523, Japan.; DEJIMA Infectious Disease Research Alliance, Nagasaki University, Nagasaki 852-8523, Japan., Takamatsu Y; Department of Virology, Institute of Tropical Medicine, Nagasaki University (ITM-NU), Nagasaki 852-8523, Japan.; Program for Nurturing Global Leaders in Tropical and Emerging Communicable Diseases, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan. |
المصدر: | Viruses [Viruses] 2024 May 29; Vol. 16 (6). Date of Electronic Publication: 2024 May 29. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI |
مواضيع طبية MeSH: | Phlebovirus*/genetics , Phlebovirus*/isolation & purification , Phlebovirus*/classification , Cat Diseases*/virology , Cat Diseases*/diagnosis , Phylogeny* , Severe Fever with Thrombocytopenia Syndrome*/diagnosis , Severe Fever with Thrombocytopenia Syndrome*/virology , Severe Fever with Thrombocytopenia Syndrome*/veterinary, Animals ; Cats ; Male ; Female ; Biomarkers/blood ; RNA, Viral/genetics ; Severity of Illness Index ; Aspartate Aminotransferases/blood ; Alanine Transaminase/blood |
مستخلص: | Severe fever with thrombocytopenia syndrome (SFTS) is a potentially fatal tick-borne zoonosis caused by SFTS virus (SFTSV). In addition to tick bites, animal-to-human transmission of SFTSV has been reported, but little is known about feline SFTSV infection. In this study, we analyzed data on 187 cats with suspected SFTS to identify biomarkers for SFTS diagnosis and clinical outcome. Body weight, red and white blood cell and platelet counts, and serum aspartate aminotransferase and total bilirubin levels were useful for SFTS diagnosis, whereas alanine aminotransferase, aspartate aminotransferase and serum SFTSV RNA levels were associated with clinical outcome. We developed a scoring model to predict SFTSV infection. In addition, we performed a phylogenetic analysis to reveal the relationship between disease severity and viral strain. This study provides comprehensive information on feline SFTS and could contribute to the protection of cat owners, community members, and veterinarians from the risk of cat-transmitted SFTSV infection. |
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معلومات مُعتمدة: | JP23fm0208101, JP23fk0108656, JP23wm0125006, JP22wm0325023, JP22fm0208101, JP21fm0208101, JP21wm0325023, and JP20wm0323023 Japan Agency for Medical Research and Development; 21K07059 and 22KK0115 Japan Society for the Promotion of Science; 2022-Ippan-12 and 2023-Ippan-16 Joint/Research Center on Tropical Disease, Institute of Tropical Medicine, Nagasaki University |
فهرسة مساهمة: | Keywords: biomarkers; cat; prognosis factors; severe fever thrombocytopenia syndrome; veterinarian |
المشرفين على المادة: | 0 (Biomarkers) 0 (RNA, Viral) EC 2.6.1.1 (Aspartate Aminotransferases) EC 2.6.1.2 (Alanine Transaminase) |
تواريخ الأحداث: | Date Created: 20240627 Date Completed: 20240627 Latest Revision: 20240629 |
رمز التحديث: | 20240629 |
مُعرف محوري في PubMed: | PMC11209305 |
DOI: | 10.3390/v16060874 |
PMID: | 38932167 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1999-4915 |
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DOI: | 10.3390/v16060874 |