دورية أكاديمية
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Heteroleptic cobalt complex augments antifungal activity with fluconazole and causes membrane disruption in Candida albicans .

التفاصيل البيبلوغرافية
العنوان: Heteroleptic cobalt complex augments antifungal activity with fluconazole and causes membrane disruption in Candida albicans .
المؤلفون: Dar OA; Department of Chemistry, Jamia Millia Islamia, New Delhi 110025, India.; College of Pharmaceutical Sciences, Southwest University, Chongqing, China., Hashmi AA; Department of Chemistry, Jamia Millia Islamia, New Delhi 110025, India., Al-Bogami AS; Department of Chemistry, College of Science, University of Jeddah, 21589 Jeddah, Saudi Arabia. mwani@uj.edu.sa., Ahmad A; Clinical Microbiology and Infectious Diseases, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 2193, South Africa. aijaz.ahmad@wits.ac.za.; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA., Wani MY; Department of Chemistry, College of Science, University of Jeddah, 21589 Jeddah, Saudi Arabia. mwani@uj.edu.sa.
المصدر: Dalton transactions (Cambridge, England : 2003) [Dalton Trans] 2024 Jul 16; Vol. 53 (28), pp. 11720-11735. Date of Electronic Publication: 2024 Jul 16.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101176026 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-9234 (Electronic) Linking ISSN: 14779226 NLM ISO Abbreviation: Dalton Trans Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : Royal Society of Chemistry, c2003-
مواضيع طبية MeSH: Fluconazole*/pharmacology , Antifungal Agents*/pharmacology , Antifungal Agents*/chemistry , Antifungal Agents*/chemical synthesis , Candida albicans*/drug effects , Cobalt*/chemistry , Cobalt*/pharmacology , Coordination Complexes*/pharmacology , Coordination Complexes*/chemistry , Coordination Complexes*/chemical synthesis , Microbial Sensitivity Tests* , Cell Membrane*/drug effects, Drug Synergism ; Drug Resistance, Fungal/drug effects
مستخلص: Heteroleptic metal complexes containing Cu II , Co II , and Zn II , incorporating curcumin and a Schiff base ligand (L), were synthesized and characterized, and their antifungal activity was evaluated. Their antifungal activities were investigated individually and in combination with fluconazole. Utilizing various analytical techniques such as UV-Vis, FT-IR, NMR, ESI-MS, TGA-DTG, elemental analyses, conductance, and magnetic susceptibility measurements, complex C1 ([Cu(Cur)LCl(H 2 O)]) was assigned a distorted octahedral geometry, while complexes C2 ([Co(Cur)LCl(H 2 O)]) and C3 ([Zn(Cur)LCl(H 2 O)]) were assigned octahedral geometries. Among these complexes, C2 exhibited the highest inhibitory activity against both FLC-susceptible and resistant strains of Candida albicans . Furthermore, C2 demonstrated candidicidal activity and synergistic interactions with fluconazole, effectively inhibiting the growth and survival of both FLC-resistant and FLC-sensitive C. albicans strains. The complex displayed a dose-dependent inhibition of drug efflux pumps in FLC-resistant C. albicans strains, indicating its potential to disrupt the cell membrane of these strains. The significant role of membrane efflux transporters in the development of antifungal drug resistance within Candida species has been extensively documented and our findings indicate that complex C2 specifically targets this crucial factor, thereby playing a pivotal role in mitigating drug resistance in C. albicans .
المشرفين على المادة: 8VZV102JFY (Fluconazole)
0 (Antifungal Agents)
3G0H8C9362 (Cobalt)
0 (Coordination Complexes)
تواريخ الأحداث: Date Created: 20240627 Date Completed: 20240716 Latest Revision: 20240716
رمز التحديث: 20240716
DOI: 10.1039/d4dt01209g
PMID: 38932585
قاعدة البيانات: MEDLINE
الوصف
تدمد:1477-9234
DOI:10.1039/d4dt01209g