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Alleviation of Menopausal Symptoms by Yam (Dioscorea japonica Thunb.) and Gromwell (Lithospermum erythrorhizon Sieb. Et Zucc.) Extracts in Ovariectomized Mice.

التفاصيل البيبلوغرافية
العنوان: Alleviation of Menopausal Symptoms by Yam (Dioscorea japonica Thunb.) and Gromwell (Lithospermum erythrorhizon Sieb. Et Zucc.) Extracts in Ovariectomized Mice.
المؤلفون: Park H; Department of Food Science and Biotechnology, Kyung Hee University, Yongin, 17104, Republic of Korea., Ha H; Department of Food Science and Biotechnology, Kyung Hee University, Yongin, 17104, Republic of Korea., Lee H; Department of Food Science and Biotechnology, Kyung Hee University, Yongin, 17104, Republic of Korea., Lee G; Department of Food Science and Biotechnology, Kyung Hee University, Yongin, 17104, Republic of Korea., Go GW; Department of Food and Nutrition, Hanyang University, Seoul, 04763, Republic of Korea., Yoon TM; Antimicrobial Materials Lab., Dynesoze Co., Ltd., R&D Center, Yongin, 16827, Republic of Korea., Kim TY; Antimicrobial Materials Lab., Dynesoze Co., Ltd., R&D Center, Yongin, 16827, Republic of Korea., Kim W; Department of Food and Nutrition, Yonsei University, Seoul, 03722, Republic of Korea.
المصدر: Molecular nutrition & food research [Mol Nutr Food Res] 2024 Aug; Vol. 68 (15), pp. e2400158. Date of Electronic Publication: 2024 Jun 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101231818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1613-4133 (Electronic) Linking ISSN: 16134125 NLM ISO Abbreviation: Mol Nutr Food Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Weinheim, Germany : Wiley-VCH, c2004-
مواضيع طبية MeSH: Dioscorea*/chemistry , Ovariectomy* , Plant Extracts*/pharmacology , Menopause*/drug effects, Animals ; Female ; Uterus/drug effects ; Mice ; Phytoestrogens/pharmacology ; Weight Gain/drug effects ; Glucose Intolerance/drug therapy ; Mice, Inbred C57BL ; Osteoporosis/drug therapy ; Osteoporosis/prevention & control ; Estrogens/pharmacology ; Estrogens/deficiency
مستخلص: Scope: The decline in estrogen during menopause contributes to a variety of menopausal symptoms, for which hormone replacement therapy (HRT) has been extensively applied. Regarding side effects and limited effectiveness of HRT for specific individuals, there is a growing interest in safe alternatives such as phytoestrogens which are structurally analogous to estrogens. This study aims to investigate the efficacy of yam and gromwell extracts, rich in bioactive compounds, and the synergistic effect of extracts on symptoms induced by estrogen deficiency in ovariectomized (OVX) mice.
Methods and Results: OVX mice receive dietary intervention of either yam, gromwell extract, or their mixture for 14 weeks. Sham-operated mice and E2-injected OVX mice serve as positive controls. Following 14 weeks of oral administration, blood, adipose tissue, vagina, uterus, femurs, and tibias are harvested for further investigation. Consequently, yam and gromwell extracts ameliorate menopausal conditions such as weight gain, glucose intolerance, dyslipidemia, and osteoporosis in estrogen-deficient OVX mice. In addition, the mixture of yam and gromwell extracts synergistically aids in the relief of the indications.
Conclusion: These results indicate the potential use of yam and gromwell extracts, as well as their mixture, for the development of healthy functional foods to modulate menopausal symptoms.
(© 2024 Wiley‐VCH GmbH.)
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معلومات مُعتمدة: S3266988 Technology Development Program funded by the Ministry of SMEs and Startups (MSS, Korea); 2023R1A2C1002852 National Research Foundation of Korea
فهرسة مساهمة: Keywords: functional foods; herbs; menopause; ovariectomy; phytoestrogen
المشرفين على المادة: 0 (Plant Extracts)
0 (Phytoestrogens)
0 (Estrogens)
تواريخ الأحداث: Date Created: 20240627 Date Completed: 20240816 Latest Revision: 20240816
رمز التحديث: 20240816
DOI: 10.1002/mnfr.202400158
PMID: 38934532
قاعدة البيانات: MEDLINE
الوصف
تدمد:1613-4133
DOI:10.1002/mnfr.202400158