First report of Leishmania tropica in domestic and wild animal hosts in hyperendemic areas of human cutaneous leishmaniasis in western Yemen: a neglected tropical disease needing One Health approach.

التفاصيل البيبلوغرافية
العنوان:	First report of Leishmania tropica in domestic and wild animal hosts in hyperendemic areas of human cutaneous leishmaniasis in western Yemen: a neglected tropical disease needing One Health approach.
المؤلفون:	Al-Ashwal MA; Department of Parasitology, Faculty of Medicine, Universiti Malaya, 50603, Kuala Lumpur, Malaysia., Al-Adhroey AH; Department of Community Medicine, Faculty of Medicine, Thamar University, Dhamar, Yemen., Atroosh WM; Department of Parasitology, Faculty of Medicine, Universiti Malaya, 50603, Kuala Lumpur, Malaysia. wahib_atrosh@yahoo.com.; Department of Microbiology and Parasitology, Faculty of Medicine and Health Sciences, University of Aden, Aden, Yemen. wahib_atrosh@yahoo.com., Al-Subbary AA; National Centre of Public Health Laboratories, Ministry of Health and Population, Dhamar, Yemen., Albhri AA; Al-Medan Health Centre, Ministry of Health and Population, Dhamar, Yemen., Azlan UW; Department of Parasitology, Faculty of Medicine, Universiti Malaya, 50603, Kuala Lumpur, Malaysia., Tan JH; Department of Parasitology, Faculty of Medicine, Universiti Malaya, 50603, Kuala Lumpur, Malaysia., Alkhali AA; Laboratory of Biotechnology, Environment and Quality, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco., Alshoteri SA; Department of Microbiology and Parasitology, Faculty of Medicine and Health Sciences, University of Aden, Aden, Yemen., Sady H; Centre for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Alharazi TH; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Hail, Hail, Kingdom of Saudi Arabia.; Department of Medical Parasitology, Faculty of Medicine and Health Sciences, Taiz University, Taiz, Yemen., Lau YL; Department of Parasitology, Faculty of Medicine, Universiti Malaya, 50603, Kuala Lumpur, Malaysia., Al-Mekhlafi HM; Department of Parasitology, Faculty of Medicine, Universiti Malaya, 50603, Kuala Lumpur, Malaysia. halmekhlafi@yahoo.com.; Department of Epidemiology, Faculty of Public Health and Tropical Medicine, Jazan University, 45142, Jazan, Saudi Arabia. halmekhlafi@yahoo.com.; Department of Parasitology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a 1247, Yemen. halmekhlafi@yahoo.com.
المصدر:	Parasitology research [Parasitol Res] 2024 Jun 27; Vol. 123 (6), pp. 256. Date of Electronic Publication: 2024 Jun 27.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Springer International Country of Publication: Germany NLM ID: 8703571 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1955 (Electronic) Linking ISSN: 09320113 NLM ISO Abbreviation: Parasitol Res Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Berlin : Springer International, c1987-
مواضيع طبية MeSH:	Leishmania tropica/genetics , Leishmania tropica/isolation & purification , Leishmania tropica/classification , Leishmaniasis, Cutaneous/epidemiology , Leishmaniasis, Cutaneous/veterinary , Leishmaniasis, Cutaneous/parasitology , Animals, Wild/parasitology , Animals, Domestic/parasitology , Phylogeny* , One Health*, Animals ; Yemen/epidemiology ; Humans ; Cross-Sectional Studies ; DNA, Protozoan/genetics ; Neglected Diseases/parasitology ; Neglected Diseases/epidemiology ; Neglected Diseases/veterinary ; Endemic Diseases/veterinary ; DNA, Ribosomal Spacer/genetics ; Polymerase Chain Reaction/veterinary ; Sequence Analysis, DNA ; Male
مستخلص:	Cutaneous leishmaniasis (CL), a neglected tropical disease, is a major public health concern in Yemen, with Leishmania tropica identified as the main causative agent. This study aims to investigate the occurrence and distribution of Leishmania parasites in domestic and wild animals in CL endemic areas in the western highlands of Yemen. A cross-sectional study was conducted in the Utmah District of western Yemen. Blood and skin scraping specimens were collected from 122 domestic and wild animals and tested for the Leishmania DNA using internal transcribed spacer 1 (ITS1) nested polymerase chain reaction. Phylogenetic analyses were performed on 20 L. tropica sequences obtained from animals in this study and 34 sequences from human isolates (collected concurrently from the same study area) retrieved from the GenBank. Overall, L. tropica was detected in 16.4% (20/122) of the examined animals, including 11 goats, two dogs, two bulls, one cow, one donkey, one rabbit, one rat and one bat. None of the examined cats and sheep was positive. The animal sequences were segregated into four different L. tropica haplotypes, with the majority of the animal (15/20) and human (32/34) sequences composed of one dominant haplotype/genotype. These findings represent the first confirmed evidence of natural L. tropica infections in different kinds of domestic and wild animals in western Yemen, suggesting these animals potentially have a role in the transmission of CL in Yemen. Therefore, a One Health approach is required for the effective prevention and control of this devastating disease among endemic populations. (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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معلومات مُعتمدة:	RG331-15AFR Universiti Malaya
فهرسة مساهمة:	Keywords: Leishmania tropica; Cutaneous leishmaniasis; Domestic animal; Infectious diseases; Reservoir hosts; Wild animal; Yemen
المشرفين على المادة:	0 (DNA, Protozoan) 0 (DNA, Ribosomal Spacer)
تواريخ الأحداث:	Date Created: 20240627 Date Completed: 20240627 Latest Revision: 20240703
رمز التحديث:	20240703
DOI:	10.1007/s00436-024-08273-3
PMID:	38935203
قاعدة البيانات:	MEDLINE

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تدمد:	1432-1955
DOI:	10.1007/s00436-024-08273-3