دورية أكاديمية
Risk factors for corneal graft rejection after penetrating keratoplasty for keratoconus.
| العنوان: | Risk factors for corneal graft rejection after penetrating keratoplasty for keratoconus. |
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| المؤلفون: | Alsubaie H; Anterior Segment Division, King Khaled Eye Specialist Hospital, Al Urubah Rd, 11462, Riyadh, Saudi Arabia., Alrubaian A; Anterior Segment Division, King Khaled Eye Specialist Hospital, Al Urubah Rd, 11462, Riyadh, Saudi Arabia.; Department of Ophthalmology, College of Medicine, Al-Imam Muhammad Ibn Saud Islamic University, Riyadh, Saudi Arabia., Ahmad K; Department of Research, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia., Ahad MA; Anterior Segment Division, King Khaled Eye Specialist Hospital, Al Urubah Rd, 11462, Riyadh, Saudi Arabia. mahad@kkesh.med.sa. |
| المصدر: | International ophthalmology [Int Ophthalmol] 2024 Jun 27; Vol. 44 (1), pp. 286. Date of Electronic Publication: 2024 Jun 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Kluwer Country of Publication: Netherlands NLM ID: 7904294 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-2630 (Electronic) Linking ISSN: 01655701 NLM ISO Abbreviation: Int Ophthalmol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Dordrecht : Kluwer Original Publication: The Hague, Junk. |
| مواضيع طبية MeSH: | Keratoplasty, Penetrating*/adverse effects , Keratoplasty, Penetrating*/methods , Keratoconus*/surgery , Graft Rejection*/epidemiology , Graft Rejection*/etiology , Graft Survival*, Humans ; Male ; Retrospective Studies ; Female ; Risk Factors ; Adult ; Middle Aged ; Follow-Up Studies ; Visual Acuity ; Young Adult ; Incidence ; Postoperative Complications/epidemiology ; Adolescent |
| مستخلص: | Purpose: To evaluate the association between donor-related factors and the risk of rejection in patients undergoing penetrating keratoplasty (PKP) for keratoconus. Methods: A retrospective review was performed of keratoconus patients with no corneal neovascularization who underwent PKP from November 2014 to December 2016 and completed at least two years of follow-up. Preoperative, donor, operative, and postoperative data were collected and analyzed to identify factors leading to corneal graft rejection. Results: A total of 201 eyes (of 201 patients) that underwent PKP for keratoconus were included. Of these, 22.9% (95% CI 17.6-29.2%) had an episode of graft rejection. The overall graft survival rate was 98.5%. Receipts with a history of corneal transplant in the fellow eye (IRR 1.69, 95% CI 1.01, 2.80; p = 0.044) and those with postoperative stromal neovascularization (IRR 2.51, 95% CI 1.49, 4.21; p = 0.001) had a significantly higher incidence of rejection than those without these features. In univariate analysis, death-to-surgery time and death-to-excision time (DET) showed a weak association with graft rejection (p 0.05 and 0.08 respectively); However, in the multivariable analysis, this significance was lost. Grafts with a death-to-excision time (DET) greater than 8 h had a 0.53X lower risk of rejection compared with grafts with DET within 8 h or less (p = 0.05). Rejection was higher in patients receiving grafts with a preservation time within 7 days or less compared with preservation time greater than 7 days (30.6% vs. 21.2%, respectively, p = 0.291). Conclusion: In the multivariable analysis, none of the donor-related factors were significantly associated with graft rejection; however, short death-to-surgery time may be associated with rejection after PKP. Recipients with a history of PKP in the fellow eye and those who developed corneal neovascularization were also at increased risk of developing rejection after keratoplasty. (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.) |
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| فهرسة مساهمة: | Keywords: Graft rejection; Keratoconus; Penetrating keratoplasty |
| تواريخ الأحداث: | Date Created: 20240627 Date Completed: 20240627 Latest Revision: 20240627 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1007/s10792-024-02955-8 |
| PMID: | 38935251 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1573-2630 |
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| DOI: | 10.1007/s10792-024-02955-8 |