دورية أكاديمية
Antifungal efficacy of natural antiseptic products against Candida auris.
| العنوان: | Antifungal efficacy of natural antiseptic products against Candida auris. |
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| المؤلفون: | Wu WG; Department of Pathology, Princess Margaret Hospital, Hong Kong, Special Administrative Region, China., Luk KS; Department of Pathology, Princess Margaret Hospital, Hong Kong, Special Administrative Region, China.; Infection Control Team, Princess Margaret Hospital, Hong Kong, Special Administrative Region, China.; Infection Control Team, Caritas Medical Centre, Hong Kong, Special Administrative Region, China.; Infection Control Team, Yan Chai Hospital, Hong Kong, Special Administrative Region, China., Hung MF; Department of Pathology, Princess Margaret Hospital, Hong Kong, Special Administrative Region, China., Tsang WY; Department of Pathology, Princess Margaret Hospital, Hong Kong, Special Administrative Region, China., Lee KP; Department of Pathology, Princess Margaret Hospital, Hong Kong, Special Administrative Region, China.; Infection Control Team, Caritas Medical Centre, Hong Kong, Special Administrative Region, China., Lam BH; Department of Pathology, Princess Margaret Hospital, Hong Kong, Special Administrative Region, China., Cheng KL; Infection Control Team, Caritas Medical Centre, Hong Kong, Special Administrative Region, China., Cheung WS; Infection Control Team, Princess Margaret Hospital, Hong Kong, Special Administrative Region, China., Tang HL; Infection Control Team, Yan Chai Hospital, Hong Kong, Special Administrative Region, China., To WK; Department of Pathology, Princess Margaret Hospital, Hong Kong, Special Administrative Region, China.; Infection Control Team, Princess Margaret Hospital, Hong Kong, Special Administrative Region, China. |
| المصدر: | Medical mycology [Med Mycol] 2024 Jul 04; Vol. 62 (7). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 9815835 Publication Model: Print Cited Medium: Internet ISSN: 1460-2709 (Electronic) Linking ISSN: 13693786 NLM ISO Abbreviation: Med Mycol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2014- : Oxford : Oxford University Press Original Publication: Oxford : Blackwell Science, c1998- |
| مواضيع طبية MeSH: | Microbial Sensitivity Tests* , Anti-Infective Agents, Local*/pharmacology , Antifungal Agents*/pharmacology , Candida auris*/drug effects, Humans ; Tea Tree Oil/pharmacology ; Honey ; Chlorhexidine/pharmacology ; Leptospermum/chemistry |
| مستخلص: | Candida auris is an emerging fungal pathogen responsible for healthcare-associated infections and outbreaks with high mortality around the world. It readily colonizes the skin, nares, respiratory and urinary tract of hospitalized patients, and such colonization may lead to invasive Candida infection in susceptible patients. However, there is no recommended decolonization protocol for C. auris by international health authorities. The aim of this study is to evaluate the susceptibility of C. auris to commonly used synthetic and natural antiseptic products using an in vitro, broth microdilution assay. Synthetic antiseptics including chlorhexidine, povidone-iodine, and nystatin were shown to be fungicidal against C. auris. Among the natural antiseptics tested, tea tree oil and manuka oil were both fungicidal against C. auris at concentrations less than or equal to 1.25% (v/v). Manuka honey inhibited C. auris at 25% (v/v) concentrations. Among the commercial products tested, manuka body wash and mouthwash were fungicidal against C. auris at concentrations less than or equal to 0.39% (w/v) and 6.25% (v/v) of products as supplied for use, respectively, while tea tree body wash and MedihoneyTM wound gel demonstrated fungistatic properties. In conclusion, this study demonstrated good in vitro antifungal efficacy of tea tree oil, manuka oil, manuka honey, and commercially available antiseptic products containing these active ingredients. Future studies are warranted to evaluate the effectiveness of these antiseptic products in clinical settings. (© The Author(s) 2024. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology.) |
| معلومات مُعتمدة: | 2023-CRC-MRG-02 Clinical Research Centre Mini Research; Hospital Authority |
| فهرسة مساهمة: | Keywords: Candida auris; decolonization; manuka; natural; tea tree Local Abstract: [plain-language-summary] Candida auris is an emerging superbug fungus that poses a serious threat to global public health. The excellent antifungal efficacy of natural antiseptics and their commercial hygiene products provide new insights into the development of an alternative decolonization regimen against C. auris. |
| المشرفين على المادة: | 0 (Anti-Infective Agents, Local) 0 (Antifungal Agents) 68647-73-4 (Tea Tree Oil) R4KO0DY52L (Chlorhexidine) |
| تواريخ الأحداث: | Date Created: 20240627 Date Completed: 20240716 Latest Revision: 20240716 |
| رمز التحديث: | 20240717 |
| DOI: | 10.1093/mmy/myae060 |
| PMID: | 38936838 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1460-2709 |
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| DOI: | 10.1093/mmy/myae060 |