دورية أكاديمية
أعرض في EDS

Enhanced Synaptic Inhibition in the Dorsolateral Geniculate Nucleus in a Mouse Model of Glaucoma.

التفاصيل البيبلوغرافية
العنوان: Enhanced Synaptic Inhibition in the Dorsolateral Geniculate Nucleus in a Mouse Model of Glaucoma.
المؤلفون: Van Hook MJ; Department of Ophthalmology and Visual Sciences, Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198 matt.vanhook@unmc.edu.; Departments of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska 68198., McCool S; Department of Ophthalmology and Visual Sciences, Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198.; Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198.
المصدر: ENeuro [eNeuro] 2024 Jul 11; Vol. 11 (7). Date of Electronic Publication: 2024 Jul 11 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 101647362 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2373-2822 (Electronic) Linking ISSN: 23732822 NLM ISO Abbreviation: eNeuro Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Washington, DC] : Society for Neuroscience, [2014]-
مواضيع طبية MeSH: Geniculate Bodies*/physiology , Glaucoma*/metabolism , Glaucoma*/physiopathology , Glaucoma*/pathology , Mice, Inbred DBA* , Disease Models, Animal* , Neural Inhibition*/physiology , Synapses*/physiology , Synapses*/metabolism, Animals ; Male ; Inhibitory Postsynaptic Potentials/physiology ; Mice ; Female ; Intraocular Pressure/physiology ; Receptors, GABA-A/metabolism
مستخلص: Elevated intraocular pressure (IOP) triggers glaucoma by damaging the output neurons of the retina called retinal ganglion cells (RGCs). This leads to the loss of RGC signaling to visual centers of the brain such as the dorsolateral geniculate nucleus (dLGN), which is critical for processing and relaying information to the cortex for conscious vision. In response to altered levels of activity or synaptic input, neurons can homeostatically modulate postsynaptic neurotransmitter receptor numbers, allowing them to scale their synaptic responses to stabilize spike output. While prior work has indicated unaltered glutamate receptor properties in the glaucomatous dLGN, it is unknown whether glaucoma impacts dLGN inhibition. Here, using DBA/2J mice, which develop elevated IOP beginning at 6-7 months of age, we tested whether the strength of inhibitory synapses on dLGN thalamocortical relay neurons is altered in response to the disease state. We found an enhancement of feedforward disynaptic inhibition arising from local interneurons along with increased amplitude of quantal inhibitory synaptic currents. A combination of immunofluorescence staining for the γ-aminobutyric acid (GABA) A -α1 receptor subunit, peak-scaled nonstationary fluctuation analysis, and measures of homeostatic synaptic scaling pointed to an ∼1.4-fold increase in GABA receptors at postsynaptic inhibitory synapses, although several pieces of evidence indicate a nonuniform scaling across inhibitory synapses within individual relay neurons. Together, these results indicate an increase in inhibitory synaptic strength in the glaucomatous dLGN, potentially pointing toward homeostatic compensation for disruptions in network and neuronal function triggered by increased IOP.
Competing Interests: The authors declare no competing financial interests.
(Copyright © 2024 Van Hook and McCool.)
التعليقات: Update of: bioRxiv. 2024 Mar 30:2024.03.27.587036. doi: 10.1101/2024.03.27.587036. (PMID: 38586044)
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معلومات مُعتمدة: R01 EY030507 United States EY NEI NIH HHS
فهرسة مساهمة: Keywords: GABA; glaucoma; homeostatic plasticity; inhibition; synaptic scaling; thalamus
المشرفين على المادة: 0 (Receptors, GABA-A)
تواريخ الأحداث: Date Created: 20240627 Date Completed: 20240711 Latest Revision: 20240714
رمز التحديث: 20240714
مُعرف محوري في PubMed: PMC11242868
DOI: 10.1523/ENEURO.0263-24.2024
PMID: 38937109
قاعدة البيانات: MEDLINE
الوصف
تدمد:2373-2822
DOI:10.1523/ENEURO.0263-24.2024