دورية أكاديمية
أعرض في EDS

Identifying plasma proteomic signatures from health to heart failure, across the ejection fraction spectrum.

التفاصيل البيبلوغرافية
العنوان: Identifying plasma proteomic signatures from health to heart failure, across the ejection fraction spectrum.
المؤلفون: Andrzejczyk K; Department of Cardiology, Thorax Center, Cardiovascular Institute, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Abou Kamar S; Department of Cardiology, Thorax Center, Cardiovascular Institute, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Department of Cardiology, Franciscus Gasthuis & Vlietland, Rotterdam, The Netherlands., van Ommen AM; Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Canto ED; Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Department of General Practice & Nursing Science, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Petersen TB; Department of Cardiology, Thorax Center, Cardiovascular Institute, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Department of Biostatistics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Valstar G; Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Akkerhuis KM; Department of Cardiology, Thorax Center, Cardiovascular Institute, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Cramer MJ; Clinical Cardiology Department, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Umans V; Department of Cardiology, Northwest Clinics, Alkmaar, the Netherlands., Rutten FH; Department of General Practice & Nursing Science, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Teske A; Clinical Cardiology Department, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Boersma E; Department of Cardiology, Thorax Center, Cardiovascular Institute, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Menken R; Cardiology Centers of the Netherlands, Utrecht, The Netherlands., van Dalen BM; Department of Cardiology, Thorax Center, Cardiovascular Institute, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Department of Cardiology, Franciscus Gasthuis & Vlietland, Rotterdam, The Netherlands., Hofstra L; Cardiology Centers of the Netherlands, Utrecht, The Netherlands., Verhaar M; Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Brugts J; Department of Cardiology, Thorax Center, Cardiovascular Institute, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Asselbergs F; Clinical Cardiology Department, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., den Ruijter H; Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Clinical Cardiology Department, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Kardys I; Department of Cardiology, Thorax Center, Cardiovascular Institute, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. i.kardys@erasmusmc.nl.
المصدر: Scientific reports [Sci Rep] 2024 Jun 27; Vol. 14 (1), pp. 14871. Date of Electronic Publication: 2024 Jun 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Heart Failure*/blood , Heart Failure*/metabolism , Heart Failure*/physiopathology , Stroke Volume* , Proteomics*/methods, Humans ; Female ; Male ; Aged ; Middle Aged ; Proteome/metabolism ; Proteome/analysis ; Biomarkers/blood ; Blood Proteins/metabolism
مستخلص: Circulating proteins may provide insights into the varying biological mechanisms involved in heart failure (HF) with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF). We aimed to identify specific proteomic patterns for HF, by comparing proteomic profiles across the ejection fraction spectrum. We investigated 4210 circulating proteins in 739 patients with normal (Stage A/Healthy) or elevated (Stage B) filling pressures, HFpEF, or ischemic HFrEF (iHFrEF). We found 2122 differentially expressed proteins between iHFrEF-Stage A/Healthy, 1462 between iHFrEF-HFpEF and 52 between HFpEF-Stage A/Healthy. Of these 52 proteins, 50 were also found in iHFrEF vs. Stage A/Healthy, leaving SLITRK6 and NELL2 expressed in lower levels only in HFpEF. Moreover, 108 proteins, linked to regulation of cell fate commitment, differed only between iHFrEF-HFpEF. Proteomics across the HF spectrum reveals overlap in differentially expressed proteins compared to stage A/Healthy. Multiple proteins are unique for distinguishing iHFrEF from HFpEF, supporting the capacity of proteomics to discern between these conditions.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Biomarkers; HFpEF; HFrEF; Heart failure; Proteomics
المشرفين على المادة: 0 (Proteome)
0 (Biomarkers)
0 (Blood Proteins)
تواريخ الأحداث: Date Created: 20240627 Date Completed: 20240627 Latest Revision: 20240630
رمز التحديث: 20240630
مُعرف محوري في PubMed: PMC11211454
DOI: 10.1038/s41598-024-65667-0
PMID: 38937570
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-024-65667-0