دورية أكاديمية
When synchronous mucinous metaplasia and neoplasia of the female genital tract and peutz-jeghers syndrome meet: a case report and literature reviews.
| العنوان: | When synchronous mucinous metaplasia and neoplasia of the female genital tract and peutz-jeghers syndrome meet: a case report and literature reviews. |
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| المؤلفون: | Zhou Y; College of Medicine, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong, People's Republic of China.; Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, Shandong, People's Republic of China.; Shandong Engineering Laboratory for Urogynecology, Qilu Hospital of Shandong University, Jinan, Shandong, People's Republic of China., Wang X; College of Medicine, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong, People's Republic of China.; Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, Shandong, People's Republic of China.; Shandong Engineering Laboratory for Urogynecology, Qilu Hospital of Shandong University, Jinan, Shandong, People's Republic of China., Li Y; College of Medicine, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong, People's Republic of China.; Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, Shandong, People's Republic of China.; Shandong Engineering Laboratory for Urogynecology, Qilu Hospital of Shandong University, Jinan, Shandong, People's Republic of China., Zhang W; College of Medicine, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong, People's Republic of China.; Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, Shandong, People's Republic of China.; Shandong Engineering Laboratory for Urogynecology, Qilu Hospital of Shandong University, Jinan, Shandong, People's Republic of China., Xu X; College of Medicine, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong, People's Republic of China.; Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, Shandong, People's Republic of China.; Shandong Engineering Laboratory for Urogynecology, Qilu Hospital of Shandong University, Jinan, Shandong, People's Republic of China., Pang Y; College of Medicine, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong, People's Republic of China. yingxinpang@126.com.; Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, Shandong, People's Republic of China. yingxinpang@126.com.; Shandong Engineering Laboratory for Urogynecology, Qilu Hospital of Shandong University, Jinan, Shandong, People's Republic of China. yingxinpang@126.com., Liu P; College of Medicine, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong, People's Republic of China. peishuliu@126.com.; Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, Shandong, People's Republic of China. peishuliu@126.com.; Shandong Engineering Laboratory for Urogynecology, Qilu Hospital of Shandong University, Jinan, Shandong, People's Republic of China. peishuliu@126.com. |
| المصدر: | BMC women's health [BMC Womens Health] 2024 Jun 28; Vol. 24 (1), pp. 375. Date of Electronic Publication: 2024 Jun 28. |
| نوع المنشور: | Case Reports; Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101088690 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6874 (Electronic) Linking ISSN: 14726874 NLM ISO Abbreviation: BMC Womens Health Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : BioMed Central, 2001- |
| مواضيع طبية MeSH: | Peutz-Jeghers Syndrome*/complications , Peutz-Jeghers Syndrome*/diagnosis , Peutz-Jeghers Syndrome*/pathology , Metaplasia*, Humans ; Female ; Genital Neoplasms, Female/pathology ; Genital Neoplasms, Female/diagnosis ; Adenocarcinoma, Mucinous/diagnosis ; Adenocarcinoma, Mucinous/pathology ; Adenocarcinoma, Mucinous/complications ; Ovarian Neoplasms/pathology ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/complications ; Adult ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/complications ; Neoplasms, Multiple Primary/pathology ; Neoplasms, Multiple Primary/diagnosis |
| مستخلص: | Background: Peutz-Jeghers syndrome (PJS) is characterized by the presence of hamartomatous polyps in the gastrointestinal tract and mucocutaneous pigmentation on the lips, oral mucosa, nose, fingers, and toes. Synchronous mucinous metaplasia and neoplasia of the female genital tract (SMMN-FGT) refers to the occurrence of multifocal mucinous lesions in at least two sites, including the cervix, uterus, fallopian tubes, and ovaries, in the female genital tract. SMMN-FGT and PJS are rare diseases with a very low incidence, especially when occurring simultaneously. Case Presentation: We report a case in which a woman with a large mass on the left ovary underwent a gynecological surgery and was diagnosed with cervical gastric-type adenocarcinoma and mucinous lesions in the endometrium, bilateral fallopian tubes, and ovary, i.e., SMMN-FGT, by postoperative paraffin pathology. The patient sought medical attention for abdominal distension and enlargement. A gynecological ultrasound revealed a multilocular cystic mass in the pelvis, while serum tumor markers were within normal limits, with mildly elevated carbohydrate antigen 199 and carbohydrate antigen 125 levels. Cervical thin-prep cytology test result was negative. The patient had a family history of PJS with black spots on her skin and mucous membranes since the age of 8 years. She underwent multiple partial small bowel resections and gastrointestinal polypectomy owing to intestinal obstruction and intussusception. She underwent left adnexectomy, hysterectomy, right salpingectomy, greater omental resection, appendectomy and right ovary biopsy, and received six courses of adjuvant chemotherapy with Lopressor plus Carboplatin. Genetic testing revealed a heterozygous serine threonine kinase 11 germline mutation and there were no signs of recurrence during the 18-month follow-up period after treatment. Conclusions: This is a rare case in which PJS was complicated by SMMN-FGT. Owing to its extreme rarity, there are no guidelines, but reported cases appear to indicate a poor prognosis. We retrospectively reviewed all cases of collisions between PJS and SMMN-FGT and explored the clinical features, pathological characteristics, diagnosis, treatment methods, and prognosis when the two diseases coexisted. The aim is to deepen the clinicians' understanding of this disease for early detection, diagnosis and treatment. (© 2024. The Author(s).) |
| References: | Gynecol Oncol. 1991 Jul;42(1):74-8. (PMID: 1916514) Tumour Biol. 2017 Jun;39(6):1010428317705131. (PMID: 28653895) N Engl J Med. 1949 Dec 29;241(26):1031-6. (PMID: 15398245) J Oncol. 2020 Jul 14;2020:6384190. (PMID: 32733558) Gynecol Oncol. 2004 Jan;92(1):337-42. (PMID: 14751181) Obstet Gynecol. 1977 Jul;50(1 Suppl):15s-17s. (PMID: 876533) Arch Anat Cytol Pathol. 1981;29(6):353-7. (PMID: 6275805) Am J Surg Pathol. 2015 Nov;39(11):1449-57. (PMID: 26457350) Am J Gastroenterol. 2015 Feb;110(2):223-62; quiz 263. (PMID: 25645574) Am J Surg Pathol. 2021 Aug 1;45(8):1061-1074. (PMID: 33534223) Am J Surg Pathol. 1994 Dec;18(12):1205-12. (PMID: 7977943) Adv Anat Pathol. 2019 Jan;26(1):1-12. (PMID: 30234500) Hum Pathol. 1986 Aug;17(8):858-61. (PMID: 3733073) Nature. 1998 Jan 8;391(6663):184-7. (PMID: 9428765) Pathol Int. 2011 Jun;61(6):369-72. (PMID: 21615613) Histopathology. 2009 Jan;54(2):184-91. (PMID: 19207943) Int J Surg Pathol. 2023 Feb;31(1):92-97. (PMID: 35466733) |
| معلومات مُعتمدة: | ZR2020QH044 Natural Science Foundation of Shandong Province; ZR2020MH272 Natural Science Foundation of Shandong Province; ZR2020MH272 Natural Science Foundation of Shandong Province |
| فهرسة مساهمة: | Keywords: Adenocarcinoma; Female genital tract; Mucinous metaplasia and neoplasia; Peutz-Jeghers syndrome; STK11 |
| تواريخ الأحداث: | Date Created: 20240627 Date Completed: 20240628 Latest Revision: 20240630 |
| رمز التحديث: | 20240630 |
| مُعرف محوري في PubMed: | PMC11212150 |
| DOI: | 10.1186/s12905-024-03184-y |
| PMID: | 38937781 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1472-6874 |
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| DOI: | 10.1186/s12905-024-03184-y |