دورية أكاديمية
Synthesis, biological evaluation, and molecular docking of novel 1,3,4-substituted-thiadiazole derivatives as potential anticancer agent.
العنوان: | Synthesis, biological evaluation, and molecular docking of novel 1,3,4-substituted-thiadiazole derivatives as potential anticancer agent. |
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المؤلفون: | Shaikh SA; Department of Chemistry, Savitribai Phule Pune University, Kr. V. N. Naik Shikshan Prasarak Sanstha's Arts, Commerce and Science College, Canada Corner, Nashik, Maharashtra, 422002, India. saminshaikh80@gmail.com.; Department of Chemistry, Savitribai Phule Pune University, KTHM College, Nashik, Maharashtra, 422002, India. saminshaikh80@gmail.com., Wakchaure SN; Department of Synthetic R & D, Delta Finochem Pvt. Ltd., G. No. 350, Wadivarhe, Igatpuri, Nashik, Maharashtra, 422403, India. satish_nclpune@yahoo.co.in.; Friedrich Alexander University Erlangen-Nuremberg (FAU), 91058, Erlangen, Germany. satish_nclpune@yahoo.co.in., Labhade SR; Department of Chemistry, Savitribai Phule Pune University, KTHM College, Nashik, Maharashtra, 422002, India., Kale RR; Department of Chemistry, Savitribai Phule Pune University, KTHM College, Nashik, Maharashtra, 422002, India., Alavala RR; SVKM's NMIMS, Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, Vile Parle (W), Mumbai, Maharashtra, 400056, India., Chobe SS; Department of Chemistry, Savitribai Phule Pune University, M.G.Vs. L. V. H. Arts, Science and Commerce College, Panchavati, Nashik, Maharashtra, 422003, India., Jain KS; Department of Chemistry, Savitribai Phule Pune University, Kr. V. N. Naik Shikshan Prasarak Sanstha's Arts, Commerce and Science College, Canada Corner, Nashik, Maharashtra, 422002, India., Labhade HS; Department of Chemistry, Savitribai Phule Pune University, KTHM College, Nashik, Maharashtra, 422002, India., Bhanushali DD; Department of Chemistry, Savitribai Phule Pune University, Kr. V. N. Naik Shikshan Prasarak Sanstha's Arts, Commerce and Science College, Canada Corner, Nashik, Maharashtra, 422002, India. |
المصدر: | BMC chemistry [BMC Chem] 2024 Jun 27; Vol. 18 (1), pp. 119. Date of Electronic Publication: 2024 Jun 27. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Nature Country of Publication: Switzerland NLM ID: 101741142 Publication Model: Electronic Cited Medium: Internet ISSN: 2661-801X (Electronic) Linking ISSN: 2661801X NLM ISO Abbreviation: BMC Chem Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Cham, Switzerland : Springer Nature, [2019]- |
مستخلص: | In an attempt to develop potent anti-cancer agents, a new 1,3,4-substituted-thiadiazole derivatives (8b-g), starting from 4-substituted-thiazol-2-chloroacetamides (4b-g), were synthesized and evaluated for their cytotoxic effects on multiple human cancer cell lines, including the hepatocellular carcinoma (HEPG-2), human lung carcinoma (A549), human breast carcinoma (MCF-7) and pseudo-normal human embryonic liver (L02) cancer cell lines by an MTT assay. Among all synthesized compounds, compound 8d showed the potent anti-cancer activities with GI (© 2024. The Author(s).) |
References: | Int J Mol Sci. 2022 May 13;23(10):. (PMID: 35628286) J Control Release. 2020 Jan 10;317:347-374. (PMID: 31751636) Nature. 1998 Jul 9;394(6689):145-51. (PMID: 9671298) Invest New Drugs. 2008 Feb;26(1):59-65. (PMID: 17938863) Anticancer Agents Med Chem. 2016;16(10):1301-14. (PMID: 27484056) SAR QSAR Environ Res. 2015;26(10):783-93. (PMID: 26305108) J Clin Oncol. 2010 Jun 20;28(18):3015-22. (PMID: 20479412) Br J Pharmacol. 2014 Jan;171(1):55-68. (PMID: 24102143) Eur J Med Chem. 2017 Sep 8;137:462-475. (PMID: 28624701) Redox Biol. 2020 Jan;29:101394. (PMID: 31790851) J Med Chem. 2006 Oct 19;49(21):6177-96. (PMID: 17034125) Cancer Chemother Pharmacol. 2009 Sep;64(4):723-32. (PMID: 19169685) EMBO J. 2008 Jul 9;27(13):1907-18. (PMID: 18566585) J Med Chem. 2004 Mar 25;47(7):1739-49. (PMID: 15027865) Cancers (Basel). 2021 May 01;13(9):. (PMID: 34062779) Acta Pol Pharm. 2009 Mar-Apr;66(2):161-7. (PMID: 19719050) N Engl J Med. 2012 Nov;367(18):1694-703. (PMID: 23020132) Expert Opin Ther Pat. 2017 Apr;27(4):477-505. (PMID: 27976971) |
فهرسة مساهمة: | Keywords: Anticancer agents; Antiproliferative activity; Molecular docking; Synthesis optimization; Thiazole-Thiadiazole compounds |
تواريخ الأحداث: | Date Created: 20240627 Latest Revision: 20240629 |
رمز التحديث: | 20240629 |
مُعرف محوري في PubMed: | PMC11210122 |
DOI: | 10.1186/s13065-024-01196-1 |
PMID: | 38937800 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2661-801X |
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DOI: | 10.1186/s13065-024-01196-1 |