دورية أكاديمية
Exploring separation mechanisms and lipophilicity in hydrophilic interaction chromatography conditions by thin-layer chromatography of anesthetics and adjuvant drugs as polar model compounds.
| العنوان: | Exploring separation mechanisms and lipophilicity in hydrophilic interaction chromatography conditions by thin-layer chromatography of anesthetics and adjuvant drugs as polar model compounds. |
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| المؤلفون: | Radoičić A; Innovative Centre of Faculty of Chemistry Ltd., Belgrade, Serbia., Šegan S; Department of Chemistry, Institute of Chemistry, Technology, and Metallurgy, University of Belgrade, Belgrade, Serbia., Milojković-Opsenica D; Department of Analytical Chemistry, University of Belgrade-Faculty of Chemistry, Belgrade, Serbia. |
| المصدر: | Journal of separation science [J Sep Sci] 2024 Jun; Vol. 47 (12), pp. e2400099. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101088554 Publication Model: Print Cited Medium: Internet ISSN: 1615-9314 (Electronic) Linking ISSN: 16159306 NLM ISO Abbreviation: J Sep Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Weinheim, Germany : Wiley-VCH, c2001- |
| مواضيع طبية MeSH: | Hydrophobic and Hydrophilic Interactions*, Chromatography, Thin Layer ; Solvents/chemistry ; Adsorption ; Chromatography, Liquid |
| مستخلص: | The chromatographic behavior of the selected compounds was studied under conditions of hydrophilic interaction liquid chromatography (HILIC). The effect of mobile phase composition on the retention in different chromatographic systems was systematically examined using high-performance thin-layer chromatography. The sorbents of different polarity and adsorption characteristics were selected and mixtures of water and organic solvents of various compositions, from pure water to pure organic solvent were used as mobile phases. Increasing the amount of water in the mobile phase leads to a conversion of the separation mechanism, and the retention curves have a characteristic "U" shape. The conversion between the adsorption and partition mechanisms is most likely continuous and depends on the chemical nature of separated substances, the stationary phase as well as on organic component of the mobile phase. Silica gel can be considered the most suitable stationary phase for the systematic investigation of the chromatographic behavior of the test compounds, whereas acetonitrile was the most suitable solvent. The obtained results contribute to the understanding of the dominant separation mechanism, the type, and the intensity of the interactions between separated substances with both stationary and mobile phases. Besides, the lipophilicity parameters obtained under HILIC conditions were evaluated and correlated with the calculated values. (© 2024 Wiley‐VCH GmbH.) |
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| معلومات مُعتمدة: | 451-03-66/2024-03/200026 Ministry of Science, Technological Development and Innovation of the Republic of Serbia; 451-03-66/2024-03/200168 Ministry of Science, Technological Development and Innovation of the Republic of Serbia; 451-03-66/2024-03/200288 Ministry of Science, Technological Development and Innovation of the Republic of Serbia |
| فهرسة مساهمة: | Keywords: hydrophilic interaction liquid chromatography; lipophilicity; retention mechanisms; small polar molecules; thin‐layer chromatography |
| المشرفين على المادة: | 0 (Solvents) |
| تواريخ الأحداث: | Date Created: 20240628 Date Completed: 20240628 Latest Revision: 20240628 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1002/jssc.202400099 |
| PMID: | 38937914 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1615-9314 |
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| DOI: | 10.1002/jssc.202400099 |