دورية أكاديمية

Pharmacokinetics of nalbuphine administered intravenously and subcutaneously in goats (Capra aegagrus hircus).

التفاصيل البيبلوغرافية
العنوان: Pharmacokinetics of nalbuphine administered intravenously and subcutaneously in goats (Capra aegagrus hircus).
المؤلفون: Garcia JD; Large Animal Clinical Sciences, University of Tennessee College of Veterinary Medicine, Knoxville, Tennessee, USA., Smith JS; Large Animal Clinical Sciences, University of Tennessee College of Veterinary Medicine, Knoxville, Tennessee, USA., Minich D; Department of Veterinary Clinical Medicine, University of Illinois Urbana-Champaign, Urbana-Champaign, Illinois, USA., Hopson M; Large Animal Clinical Sciences, University of Tennessee College of Veterinary Medicine, Knoxville, Tennessee, USA., Rahn R; Large Animal Clinical Sciences, University of Tennessee College of Veterinary Medicine, Knoxville, Tennessee, USA., Hampton C; Large Animal Clinical Sciences, University of Tennessee College of Veterinary Medicine, Knoxville, Tennessee, USA., Graves M; Large Animal Clinical Sciences, University of Tennessee College of Veterinary Medicine, Knoxville, Tennessee, USA., Bussières G; Small Animal Clinical Sciences, University of Tennessee College of Veterinary Medicine, Knoxville, Tennessee, USA., Mulon PY; Large Animal Clinical Sciences, University of Tennessee College of Veterinary Medicine, Knoxville, Tennessee, USA., Ebner LS; Lincoln Memorial University - Richard A. Gillespie College of Veterinary Medicine, Harrogate, Tennessee, USA., Cox S; Biomedical and Diagnostic Sciences, University of Tennessee College of Veterinary Medicine, Knoxville, Tennessee, USA.
المصدر: Journal of veterinary pharmacology and therapeutics [J Vet Pharmacol Ther] 2024 Jun 27. Date of Electronic Publication: 2024 Jun 27.
Publication Model: Ahead of Print
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 7910920 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2885 (Electronic) Linking ISSN: 01407783 NLM ISO Abbreviation: J Vet Pharmacol Ther Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford, Blackwell Scientific Publications.
مستخلص: The purpose of this study was to evaluate the pharmacokinetics (PK) of intravenously (IV) and subcutaneously (SC) administered nalbuphine in domestic goats. Nalbuphine hydrochloride was administered at 0.8 mg/kg for both IV and SC routes in six goats with a minimum of 10-day washout period between sample collection phases. Eighteen plasma samples were collected over a 36-hour period, analyzed using reverse phase high-performance liquid chromatography (HPLC). Plasma data were analyzed using compartmental and noncompartmental approaches. Following IV nalbuphine administration, elimination half-life, area under the plasma concentration time curve from time 0 to infinity (AUC0 - ∞), concentration at time zero (C 0 ), and total body clearance were 120.4 ± 39.1 (min -1  ± SD), 17311.01 ± 7227.32 (min·ng·mL -1  ± SD), 675.6 ± 337.13 (ng·mL -1  ± SD), and 44.5 ± 13.8 (mL·min -1 ·kg -1  ± SD), respectively. After SC nalbuphine administration, elimination half-life, area under the plasma concentration time curve from time 0 to infinity (AUC0 - ∞), and maximum plasma drug concentration were 129 ± 52.9 (min -1  ± SD), 20826.5 ± 14376.2 (min·ng·mL -1 ), and 368.03 ± 503.78 (ng·mL -1 ). Calculated bioavailability for the SC route was 138 ± 126 (% ± SD). Nalbuphine in goats is characterized by rapid elimination and high subcutaneous bioavailability and may be a safe analgesic opioid option in goats in the future.
(© 2024 John Wiley & Sons Ltd.)
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معلومات مُعتمدة: CEM, LACS
فهرسة مساهمة: Keywords: Nalbuphine; analgesia; goat; opioid; pain management; pharmacokinetics
تواريخ الأحداث: Date Created: 20240628 Latest Revision: 20240628
رمز التحديث: 20240628
DOI: 10.1111/jvp.13463
PMID: 38937921
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-2885
DOI:10.1111/jvp.13463