دورية أكاديمية
Impact of SLC22A1 variants rs622342 and rs72552763 on HbA1c and metformin plasmatic concentration levels in patients with type 2 diabetes mellitus.
العنوان: | Impact of SLC22A1 variants rs622342 and rs72552763 on HbA1c and metformin plasmatic concentration levels in patients with type 2 diabetes mellitus. |
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المؤلفون: | Ortega-Ayala A; Department of Pharmacology, Faculty of Medicine, National Autonomous University of Mexico, Mexico City 04510, Mexico., De Andrés F; Department of Analytical Chemistry and Food Technology, Faculty of Pharmacy, University of Castilla-La Mancha, 02071 Albacete, Spain., Llerena A; University Institute for Bio-sanitary Research of Extremadura, 06002 Badajoz, Spain., Bartolo-Montiel CM; Directorate of Planification, Teaching, and Research, High-Speciality Regional Hospital of Ixtapaluca, Ixtapaluca 56530, Mexico., Molina-Guarneros JA; Department of Pharmacology, Faculty of Medicine, National Autonomous University of Mexico, Mexico City 04510, Mexico. |
المصدر: | Biomedical reports [Biomed Rep] 2024 Jun 17; Vol. 21 (2), pp. 117. Date of Electronic Publication: 2024 Jun 17 (Print Publication: 2024). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: [Spandidos Publications] Country of Publication: England NLM ID: 101613227 Publication Model: eCollection Cited Medium: Internet ISSN: 2049-9442 (Electronic) Linking ISSN: 20499434 NLM ISO Abbreviation: Biomed Rep Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: [London] : [Spandidos Publications], [2013]- |
مستخلص: | Type 2 diabetes mellitus (T2DM) is a major global health problem. Response to first-line therapy is variable. This is partially due to interindividual variability across those genes codifying transport, metabolising, and drug activation proteins involved in first-line pharmacological treatment. Single nucleotide polymorphisms (SNPs) of genes SLC22A1, SLC22A2 and SLC22A3 affect metformin therapeutic response in patients with T2DM patients. The present study investigated allelic and genotypic frequencies of organic cation (OCT)1, OCT2, and OCT3 polymorphisms among metformin-treated patients with type 2 diabetes mellitus (T2DM). It also reports the association between clinical and genetic variables with glycated haemoglobin (HbA1c) control in 59 patients with T2DM. Patients were genotyped through real-time PCR (TaqMan assays). Metformin plasmatic levels were determined by mass spectrometry. Neither the analysis of HbA1c control by SNPs in SLC22A1 , SLC22A2 and SLC22A3 , nor the dominant genotypic model analysis yielded statistical significance between genotypes in polymorphisms rs72552763 (P=0.467), rs622342 (P=0.221), rs316019 (P=0.220) and rs2076828 (P=0.215). HbA1c levels were different in rs72552763 [GAT/GAT, 6.0 (5.7-6.6), GAT/del=6.5 (6.2-9.0), del/del=6.5 (6.4-6.8); P=0.022] and rs622342 [A/A=6.0 (5.8-6.5), A/C=6.4 (6.1-7.7), C/C=6.8 (6.4-9.3); P=0.009] genotypes. The dominant genotypic model found the lowest HbA1c levels in GAT/GAT (P=0.005) and A/A (P=0.010), in rs72552763 (GAT/GAT vs. GAT/del + del/del) and rs622342 (A/A vs. A/C + CC), respectively. There was a significant correlation between HbA1c levels and metformin dosage amongst del allele carriers in rs72552763 (β Competing Interests: The authors declare that they have no competing interests. (Copyright: © 2024 Ortega-Ayala et al.) |
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فهرسة مساهمة: | Keywords: HbA1c; SLC22A1; glycaemic control; metformin; organic cation 1; rs622342; rs72552763 |
تواريخ الأحداث: | Date Created: 20240628 Latest Revision: 20240629 |
رمز التحديث: | 20240629 |
مُعرف محوري في PubMed: | PMC11209864 |
DOI: | 10.3892/br.2024.1806 |
PMID: | 38938740 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2049-9442 |
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DOI: | 10.3892/br.2024.1806 |