دورية أكاديمية
Sex Differences in Coronary Artery Disease Characteristics Among Patients With Type 2 Myocardial Infarction.
| العنوان: | Sex Differences in Coronary Artery Disease Characteristics Among Patients With Type 2 Myocardial Infarction. |
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| المؤلفون: | Lin C; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., McCarthy CP; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Mohebi R; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Liu Y; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Blankstein R; Cardiovascular Division, Department of Medicine and Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA., Murphy SP; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Miksenas H; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Rogers C; HeartFlow Inc, Mountain View, California, USA., Amponsah DK; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Rambarat PK; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Raghavan A; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Levin A; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Ghoshhajra B; Division of Cardiovascular Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA., Wasfy JH; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Hedgire S; Division of Cardiovascular Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA., Januzzi JL Jr; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Heart Failure and Biomarker Clinical Trials, Baim Institute for Clinical Research, Boston, Massachusetts, USA. |
| المصدر: | JACC. Advances [JACC Adv] 2023 Dec 22; Vol. 3 (2), pp. 100795. Date of Electronic Publication: 2023 Dec 22 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Inc Country of Publication: United States NLM ID: 9918419284106676 Publication Model: eCollection Cited Medium: Internet ISSN: 2772-963X (Electronic) Linking ISSN: 2772963X NLM ISO Abbreviation: JACC Adv Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [New York] : Elsevier Inc., [2022]- |
| مستخلص: | Background: Type 2 myocardial infarction (MI) results from coronary supply and demand imbalance and has a poor prognosis. It is crucial to identify potential sex-based differences in the prevalence and nature of coronary artery disease (CAD) within this population. Objectives: The purpose of this study was to evaluate sex-based disease differences in type 2 MI among patients evaluated with coronary computed tomography angiography and fractional flow reserve. Methods: In a single-center, prospective study, patients with strictly adjudicated type 2 MI underwent coronary computed tomography angiography with fractional flow reserve. Results: Among 50 study participants enrolled, 50% were women. A similar mix of MI precipitants was present in both sexes. ST-segment depression was more common in women (64% vs 32%), while men were more likely to have T wave inversion (68% vs 36%). Women and men had comparable coronary artery calcium scores (median: 152 [Q1, Q3: 45, 762] vs 234 [Q1, Q3: 56, 422]). Prevalence of any CAD (84% vs 100%), obstructive CAD (24% vs 28%), and hemodynamically significant focal stenosis (20% vs 32%) were similar between sexes. Total plaque volume was similar between sexes, but women had significantly lower levels of low-attenuation plaque (median: 3 [Q1, Q3: 1, 7] vs 9 [Q1, Q3: 3, 14]). Conclusions: Among patients with type 2 MI, prevalence of any CAD and obstructive CAD did not differ according to sex. Total plaque volume was similar between sexes, but women had a lower volume of low-attenuation plaque (DEFINing the PrEvalence and Characteristics of Coronary Artery Disease Among Patients With TYPE 2 Myocardial Infarction Using CT-FFR [DEFINE TYPE2MI]; NCT04864119). Competing Interests: Dr Wasfy is supported by 10.13039/100000968American Heart Association (18 CDA 34110215); is chair of the New England Comparative Effectiveness Public Affairs Council (CEPAC); has received grant support from the American Heart Association and the National Institutes of Health; and has received past consulting fees from Pfizer and Biotronik. Dr Januzzi is supported by the Hutter Family Professorship. Dr McCarthy has received consulting income from Abbott Laboratories and Roche Diagnostics. Dr Ghoshhajra is on the Executive Committee of the Society of Cardiovascular Computed Tomography (President); has received grant support from 10.13039/501100011699Siemens Healthineers and the 10.13039/100000002National Institutes of Health; and received consulting fees from Siemens Healthineers, Philips Healthcare, and 3DR Labs (all unrelated to this work). Dr Rogers is an employee and shareholder of HeartFlow, Inc. Dr Blankstein has received research support from 10.13039/100002429Amgen Inc and 10.13039/100004336Novartis Inc; and has served as a consultant/advisory board for Caristo Inc, Elucid Inc, Hearflow Inc, Beren Therapeutics, Nanox AI. Dr Januzzi is a Trustee of the American College of Cardiology; a Director at Imbria Pharmaceuticals; an Advisor at Jana Care; has received grant support from 10.13039/100001316Abbott, Applied Therapeutics, 10.13039/100020588HeartFlow Inc, Innolife, and 10.13039/100016545Roche Diagnostics; consulting income from Abbott, Janssen, Novartis, Merck, and Roche Diagnostics; and participates in clinical endpoint committees/data safety monitoring boards for Abbott, AbbVie, Bayer, CVRx, Intercept, Pfizer, and Takeda. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. (© 2024 The Authors.) |
| References: | JACC Cardiovasc Imaging. 2016 Sep;9(9):1099-1113. (PMID: 27609151) Circulation. 2019 Nov 12;140(20):1661-1678. (PMID: 31416350) J Am Heart Assoc. 2017 Dec 14;6(12):. (PMID: 29242184) Int J Cardiol. 2021 Sep 1;338:24-29. (PMID: 34058288) J Cardiovasc Comput Tomogr. 2017 Nov;11(6):462-467. (PMID: 28986147) J Am Coll Cardiol. 2018 Oct 30;72(18):2231-2264. (PMID: 30153967) Am J Cardiol. 2021 May 15;147:8-15. (PMID: 33621523) Circulation. 2015 Nov 3;132(18):1710-8. (PMID: 26350057) J Am Coll Cardiol. 2019 Apr 16;73(14):1846-1860. (PMID: 30975302) J Am Coll Cardiol. 2019 Jun 25;73(24):3230-3232. (PMID: 31221266) Circulation. 2020 Jan 21;141(3):161-171. (PMID: 31587565) J Am Coll Cardiol. 2020 Mar 10;75(9):1003-1013. (PMID: 32138959) J Cardiovasc Med (Hagerstown). 2017 May;18(5):341-347. (PMID: 28107211) BMJ. 2018 Nov 7;363:k4247. (PMID: 30404896) J Am Coll Cardiol. 2022 May 17;79(19):1873-1886. (PMID: 35550683) J Am Coll Cardiol. 2021 Sep 21;78(12):1242-1253. (PMID: 34531025) Circulation. 2018 Mar 20;137(12):1236-1245. (PMID: 29150426) JACC Cardiovasc Imaging. 2024 Feb;17(2):165-175. (PMID: 37410009) Circulation. 2006 Jan 3;113(1):30-7. (PMID: 16365194) Heart. 2021 Sep;107(18):1480-1486. (PMID: 33879450) J Cardiovasc Comput Tomogr. 2017 Jul - Aug;11(4):249-257. (PMID: 28506470) J Am Coll Cardiol. 2021 Jun 29;77(25):3160-3170. (PMID: 34167641) Circ Cardiovasc Qual Outcomes. 2018 Feb;11(2):e004437. (PMID: 29449443) |
| فهرسة مساهمة: | Keywords: coronary computed tomography angiography; fractional flow reserve; sex-based differences; type 2 myocardial infarction |
| سلسلة جزيئية: | ClinicalTrials.gov NCT04864119 |
| تواريخ الأحداث: | Date Created: 20240628 Latest Revision: 20240629 |
| رمز التحديث: | 20240629 |
| مُعرف محوري في PubMed: | PMC11198490 |
| DOI: | 10.1016/j.jacadv.2023.100795 |
| PMID: | 38939381 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2772-963X |
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| DOI: | 10.1016/j.jacadv.2023.100795 |