دورية أكاديمية
Host innate immune systems gather intel on invading microbes via pathogen-derived extracellular vesicles.
| العنوان: | Host innate immune systems gather intel on invading microbes via pathogen-derived extracellular vesicles. |
|---|---|
| المؤلفون: | Kwaku GN; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Ward RA; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Vyas JM; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Harding HB; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. |
| المصدر: | Extracellular vesicle [Extracell Vesicle] 2024 Jun; Vol. 3. Date of Electronic Publication: 2024 May 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 9918487587406676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2773-0417 (Electronic) Linking ISSN: 27730417 NLM ISO Abbreviation: Extracell Vesicle Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [New York] : Elsevier, Inc., [2022]- |
| مستخلص: | Extracellular vesicles (EVs) are membrane-bound vesicles released into the extracellular milieu from various cell types including host cells and pathogens that infect them. As carriers of nucleic acids, proteins, lipids, metabolites, and virulence factors, EVs act as delivery vehicles for intercellular communication and quorum sensing. Innate immune cells have the capacity to intercept, internalize, and interpret 'messages' contained within these EVs. This review categorizes the ability of EVs secreted by bacterial, parasitic, and fungal pathogens to trigger both pro- and anti-inflammatory innate immune responses in the host. Understanding molecular pathways and inflammatory responses activated in innate immune cells upon pathogen-derived EV stimulation is critical to gain insight into potential therapeutics and combat these infectious diseases. |
| References: | Microb Cell Fact. 2023 Sep 9;22(1):177. (PMID: 37689682) Cell Rep. 2017 May 23;19(8):1545-1557. (PMID: 28538175) Int J Mol Sci. 2021 Jul 01;22(13):. (PMID: 34281154) Front Microbiol. 2021 Oct 15;12:748706. (PMID: 34721352) BMC Microbiol. 2008 Jun 02;8:87. (PMID: 18518965) Virulence. 2021 Dec;12(1):2017-2036. (PMID: 34348595) Parasit Vectors. 2022 Jul 8;15(1):245. (PMID: 35804396) mSystems. 2021 Aug 31;6(4):e0082221. (PMID: 34427507) NPJ Biofilms Microbiomes. 2023 Jun 3;9(1):30. (PMID: 37270554) Front Immunol. 2018 Apr 30;9:850. (PMID: 29760697) Nano Lett. 2015 Feb 11;15(2):1403-9. (PMID: 25615236) Proc Natl Acad Sci U S A. 2021 Nov 16;118(46):. (PMID: 34772807) Microb Pathog. 2017 Sep;110:1-6. (PMID: 28634130) Parasit Vectors. 2021 Jul 8;14(1):358. (PMID: 34238339) mSphere. 2020 May 6;5(3):. (PMID: 32376699) PLoS Negl Trop Dis. 2008 Mar 26;2(3):e209. (PMID: 18365036) Sci Rep. 2022 Aug 8;12(1):13330. (PMID: 35941134) Front Cell Infect Microbiol. 2022 Jun 06;12:879237. (PMID: 35734578) Front Immunol. 2023 Jun 29;14:1192326. (PMID: 37457708) J Extracell Vesicles. 2015 Nov 26;4:28734. (PMID: 26613751) Stem Cells. 2023 May 15;41(5):468-481. (PMID: 36827175) Parasite Immunol. 2018 Sep;40(9):e12571. (PMID: 29974519) Front Cell Infect Microbiol. 2022 Feb 28;12:834653. (PMID: 35295759) PLoS Pathog. 2018 Mar 30;14(3):e1006945. (PMID: 29601598) Exp Parasitol. 2019 Mar;198:39-45. (PMID: 30716304) Front Cell Infect Microbiol. 2022 Oct 28;12:1018314. (PMID: 36389143) Immunohorizons. 2020 Aug 20;4(8):508-519. (PMID: 32819967) Sci Rep. 2020 Oct 26;10(1):18293. (PMID: 33106559) Nat Commun. 2016 Jan 25;7:10515. (PMID: 26806181) Sci Rep. 2019 May 10;9(1):7212. (PMID: 31076615) Int J Mol Sci. 2023 Sep 03;24(17):. (PMID: 37686429) Biomaterials. 2021 Jan;268:120550. (PMID: 33278684) J Fungi (Basel). 2023 May 04;9(5):. (PMID: 37233252) Nat Commun. 2017 Sep 20;8(1):626. (PMID: 28931823) mBio. 2021 Mar 30;12(2):. (PMID: 33785616) Proteomics. 2009 Dec;9(24):5425-36. (PMID: 19834908) Int J Parasitol. 2020 Aug;50(9):685-696. (PMID: 32598872) Cell Microbiol. 2020 Oct;22(10):e13238. (PMID: 32558196) J Immunol. 2012 Mar 1;188(5):2427-36. (PMID: 22279105) Int J Mol Sci. 2023 Dec 06;24(24):. (PMID: 38139005) Front Immunol. 2020 Dec 21;11:583644. (PMID: 33408714) PLoS Negl Trop Dis. 2021 Apr 2;15(4):e0009304. (PMID: 33798196) Nat Commun. 2017 Sep 7;8(1):481. (PMID: 28883390) mBio. 2019 Apr 2;10(2):. (PMID: 30940711) Nat Cell Biol. 2007 Jun;9(6):654-9. (PMID: 17486113) NPJ Biofilms Microbiomes. 2024 Mar 21;10(1):28. (PMID: 38514622) Nat Microbiol. 2024 Jan;9(1):95-107. (PMID: 38168615) Cell Microbiol. 2015 Mar;17(3):389-407. (PMID: 25287304) Biomedicines. 2021 Aug 20;9(8):. (PMID: 34440259) Microb Pathog. 2024 Apr;189:106606. (PMID: 38437994) Crit Rev Microbiol. 2021 Feb;47(1):91-111. (PMID: 33482069) PLoS Negl Trop Dis. 2015 Sep 24;9(9):e0004069. (PMID: 26401956) Acta Trop. 2021 Jan;213:105761. (PMID: 33221281) Front Microbiol. 2019 Sep 04;10:2008. (PMID: 31551957) Infect Immun. 2010 Apr;78(4):1601-9. (PMID: 20145096) Nat Cell Biol. 2019 Jan;21(1):9-17. (PMID: 30602770) mBio. 2022 Jun 28;13(3):e0030122. (PMID: 35420476) Life Sci. 2021 Aug 15;279:119644. (PMID: 34048813) Front Microbiol. 2018 May 23;9:1036. (PMID: 29875750) Nat Commun. 2021 Oct 29;12(1):6235. (PMID: 34716343) mBio. 2021 Aug 31;12(4):e0165721. (PMID: 34253061) Curr Res Microb Sci. 2023 Mar 06;4:100185. (PMID: 36942003) PLoS Negl Trop Dis. 2021 Jan 7;15(1):e0008884. (PMID: 33411714) Front Microbiol. 2021 Jan 08;11:603183. (PMID: 33488545) |
| معلومات مُعتمدة: | R01 AI136529 United States AI NIAID NIH HHS; R01 AI150181 United States AI NIAID NIH HHS; R21 AI152499 United States AI NIAID NIH HHS |
| فهرسة مساهمة: | Keywords: Extracellular vesicles; Inflammatory pathways; Innate immunity; Therapeutics |
| تواريخ الأحداث: | Date Created: 20240628 Latest Revision: 20240630 |
| رمز التحديث: | 20240630 |
| مُعرف محوري في PubMed: | PMC11209872 |
| DOI: | 10.1016/j.vesic.2024.100043 |
| PMID: | 38939756 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2773-0417 |
|---|---|
| DOI: | 10.1016/j.vesic.2024.100043 |