دورية أكاديمية
Adjuvant ArtinM favored the host immunity against Cryptococcus gattii infection in C57BL/6 mice.
| العنوان: | Adjuvant ArtinM favored the host immunity against Cryptococcus gattii infection in C57BL/6 mice. |
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| المؤلفون: | Martins Oliveira-Brito PK; Department of Cell & Molecular Biology & Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., de Campos GY; Department of Cell & Molecular Biology & Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Guimarães JG; Department of Cell & Molecular Biology & Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Machado MP; Department of Cell & Molecular Biology & Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Serafim LC; Microbiology Postgraduate Program of the Microbiology Department of the Biomedical Sciences Institute (ICB) of University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Lazo Chica JE; Institute of Natural & Biological Sciences, Federal University of Triângulo Mineiro, Uberaba, Brazil., Roque-Barreira MC; Department of Cell & Molecular Biology & Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., da Silva TA; Department of Cell & Molecular Biology & Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.; Clinical Hematology Lab, Department of Clinical Analysis, School of Pharmaceutical Sciences in Araraquara (FCFAR), Sao Paulo State University (UNESP), Araraquara, São Paulo, Brazil.; National Institute of Science & Technology in Human Pathogenic Fungi, School of Pharmaceutical Sciences of Ribeirao Preto, University of São Paulo, Ribeirão Preto, São Paulo,Brazil. |
| المصدر: | Immunotherapy [Immunotherapy] 2024 Jun 28, pp. 1-16. Date of Electronic Publication: 2024 Jun 28. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Future Medicine Country of Publication: England NLM ID: 101485158 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-7448 (Electronic) Linking ISSN: 1750743X NLM ISO Abbreviation: Immunotherapy Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Future Medicine |
| مستخلص: | Aim: Cryptococcus gattii causes a severe fungal infection with high mortality rate among immunosuppressed and immunocompetent individuals. Due to limitation of current antifungal treatment, new immunotherapeutic approaches are explored. Methods: This study investigated an immunization strategy utilizing heat-inactivated C. gattii with ArtinM as an adjuvant. C57BL/6 mice were intranasally immunized with heat-killed C. gattii and ArtinM was administrated either before immunization or along with HK- C. gattii . Mice were infected with C. gattii and the efficacy of the immunization protocol was evaluated. Results: Mice that received ArtinM exhibited increased levels of IL-10 and relative expression of IL-23 in the lungs, reduced fungal burden and preserved tissue integrity post-infection. Conclusion: Adjuvant ArtinM improved immunization against C. gattii infection in C57BL/6 mice. |
| فهرسة مساهمة: | Keywords: ArtinM; CD14; Cryptococcus gattii; TLR2; immunomodulation; lectin; vaccine Local Abstract: [plain-language-summary] Cryptococcus gattii is a fungus that can make lungs sick. Right now, there are no good treatments for it, so scientists are trying to find new ways to fight it. In a recent study, they tested a type of immunotherapy called ArtinM to see if it could help. When they gave ArtinM to mice, the mice got healthier and had less fungus in their lungs. This means ArtinM might be able to help fight this fungus. |
| تواريخ الأحداث: | Date Created: 20240628 Latest Revision: 20240628 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1080/1750743X.2024.2360384 |
| PMID: | 38940276 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1750-7448 |
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| DOI: | 10.1080/1750743X.2024.2360384 |