دورية أكاديمية
DNA Nanocage-Assisted Size-Selective Recognition and Quantification toward Low-Mass Soluble β-Amyloid Oligomers.
العنوان: | DNA Nanocage-Assisted Size-Selective Recognition and Quantification toward Low-Mass Soluble β-Amyloid Oligomers. |
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المؤلفون: | Chen J; College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P. R. China., Liu Q; College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P. R. China., Fu Y; College of Chemistry and Chemical Engineering, Hunan University, Changsha 410083, P. R. China., Xiang J; College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P. R. China. |
المصدر: | Analytical chemistry [Anal Chem] 2024 Jul 16; Vol. 96 (28), pp. 11397-11403. Date of Electronic Publication: 2024 Jun 28. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6882 (Electronic) Linking ISSN: 00032700 NLM ISO Abbreviation: Anal Chem Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Washington, American Chemical Society. |
مواضيع طبية MeSH: | Amyloid beta-Peptides*/analysis , Amyloid beta-Peptides*/blood , Amyloid beta-Peptides*/chemistry , DNA*/chemistry, Humans ; Nanostructures/chemistry ; Particle Size ; Electrochemical Techniques/methods ; Alzheimer Disease/diagnosis ; Alzheimer Disease/metabolism ; Alzheimer Disease/blood ; Biosensing Techniques/methods ; Solubility ; Aptamers, Nucleotide/chemistry ; Molecular Weight |
مستخلص: | Low-mass soluble β-amyloid peptide oligomers (LSAβOs) play a crucial role in the pathogenesis of Alzheimer's disease. However, these oligomers exhibit heterogeneity in terms of structure, stability, and stoichiometry, and their abundance in biofluids is low, making accurate identification challenging. In this study, we developed a DNA nanocage-assisted method for selective sizing and sensitive quantification of LSAβOs in serum. Using LSAβO less than 10 kDa (LSAβO |
المشرفين على المادة: | 0 (Amyloid beta-Peptides) 9007-49-2 (DNA) 0 (Aptamers, Nucleotide) |
تواريخ الأحداث: | Date Created: 20240628 Date Completed: 20240716 Latest Revision: 20240805 |
رمز التحديث: | 20240806 |
DOI: | 10.1021/acs.analchem.4c01465 |
PMID: | 38940533 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1520-6882 |
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DOI: | 10.1021/acs.analchem.4c01465 |