دورية أكاديمية
أعرض في EDS

Absence of farnesol salvage in Candida albicans and probably in other fungi.

التفاصيل البيبلوغرافية
العنوان: Absence of farnesol salvage in Candida albicans and probably in other fungi.
المؤلفون: Voshall A; Division of Genetics and Genomics, Boston Children's Hospital, Boston, Massachusetts, USA.; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA., Gutzmann DJ; School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA., Verdaguer IB; Department of Parasitology, Institute of Biomedical Sciences of the University of São Paulo, São Paulo, Brazil., Crispim M; Department of Parasitology, Institute of Biomedical Sciences of the University of São Paulo, São Paulo, Brazil., Boone CH; School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA., Atkin AL; School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA., Nickerson KW; School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
المصدر: Applied and environmental microbiology [Appl Environ Microbiol] 2024 Jul 24; Vol. 90 (7), pp. e0087424. Date of Electronic Publication: 2024 Jun 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 7605801 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5336 (Electronic) Linking ISSN: 00992240 NLM ISO Abbreviation: Appl Environ Microbiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, American Society for Microbiology.
مواضيع طبية MeSH: Farnesol*/metabolism , Candida albicans*/drug effects , Candida albicans*/genetics , Candida albicans*/metabolism, Polyisoprenyl Phosphates/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae/drug effects ; Saccharomyces cerevisiae/growth & development ; Genome, Fungal ; Sesquiterpenes
مستخلص: Farnesol salvage, a two-step pathway converting farnesol to farnesyl pyrophosphate (FPP), occurs in bacteria, plants, and animals. This paper investigates the presence of this pathway in fungi. Through bioinformatics, biochemistry, and physiological analyses, we demonstrate its absence in the yeasts Saccharomyces cerevisiae and Candida albicans , suggesting a likely absence across fungi. We screened 1,053 fungal genomes, including 34 from C. albicans , for potential homologs to four genes ( Arabidopsis thaliana AtFOLK , AtVTE5 , AtVTE6 , and Plasmodium falciparum PfPOLK ) known to accomplish farnesol/prenol salvage in other organisms. Additionally, we showed that 3 H-farnesol was not converted to FPP or any other phosphorylated prenol, and exogenous farnesol was not metabolized within 90 minutes at any phase of growth and did not rescue cells from the toxic effects of atorvastatin, but it did elevate the levels of intracellular farnesol (F i ). All these experiments were conducted with C. albicans . In sum, we found no evidence for farnesol salvage in fungi.
Importance: The absence of farnesol salvage constitutes a major difference in the metabolic capabilities of fungi. In terms of fungal physiology, the lack of farnesol salvage pathways relates to how farnesol acts as a quorum-sensing molecule in Candida albicans and why farnesol should be investigated for use in combination with other known antifungal antibiotics. Its absence is essential for a model (K. W. Nickerson et al., Microbiol Mol Biol Rev 88:e00081-22, 2024), wherein protein farnesylation, protein chaperones, and the unfolded protein response are combined under the unifying umbrella of a cell's intracellular farnesol (F i ). In terms of human health, farnesol should have at least two different modes of action depending on whether those cells have farnesol salvage. Because animals have farnesol salvage, we can now see the importance of dietary prenols as well as the potential importance of farnesol in treating neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, and multiple sclerosis.
Competing Interests: The authors declare no conflict of interest.
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فهرسة مساهمة: Keywords: Candida albicans; ergosterol biosynthetic pathway; farnesol; salvage
المشرفين على المادة: 4602-84-0 (Farnesol)
0 (Polyisoprenyl Phosphates)
79W6B01D07 (farnesyl pyrophosphate)
0 (Sesquiterpenes)
تواريخ الأحداث: Date Created: 20240628 Date Completed: 20240724 Latest Revision: 20240726
رمز التحديث: 20240726
مُعرف محوري في PubMed: PMC11267938
DOI: 10.1128/aem.00874-24
PMID: 38940563
قاعدة البيانات: MEDLINE
الوصف
تدمد:1098-5336
DOI:10.1128/aem.00874-24