دورية أكاديمية
The role of matrix metalloproteinase-9 in cardiac remodeling and dysfunction and as a possible blood biomarker in heart failure.
| العنوان: | The role of matrix metalloproteinase-9 in cardiac remodeling and dysfunction and as a possible blood biomarker in heart failure. |
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| المؤلفون: | Rodrigues KE; Biodiversity and Biotechnology Post Graduate Program - BIONORTE, Institute of Biological Sciences, Federal University of Para, Belem, Brazil; Cardiovascular System Pharmacology and Toxicology Laboratory, Institute of Biological Sciences, Federal University of Para, Belem, Brazil., Pontes MHB; Cardiovascular System Pharmacology and Toxicology Laboratory, Institute of Biological Sciences, Federal University of Para, Belem, Brazil; Pharmacology and Biochemistry Post Graduate Program - FARMABIO, Institute of Biological Sciences, Federal University of Para, Belem, Brazil., Cantão MBS; Cardiovascular System Pharmacology and Toxicology Laboratory, Institute of Biological Sciences, Federal University of Para, Belem, Brazil; Pharmacology and Biochemistry Post Graduate Program - FARMABIO, Institute of Biological Sciences, Federal University of Para, Belem, Brazil., Prado AF; Biodiversity and Biotechnology Post Graduate Program - BIONORTE, Institute of Biological Sciences, Federal University of Para, Belem, Brazil; Cardiovascular System Pharmacology and Toxicology Laboratory, Institute of Biological Sciences, Federal University of Para, Belem, Brazil; Pharmacology and Biochemistry Post Graduate Program - FARMABIO, Institute of Biological Sciences, Federal University of Para, Belem, Brazil. Electronic address: alejandrofp@ufpa.br. |
| المصدر: | Pharmacological research [Pharmacol Res] 2024 Aug; Vol. 206, pp. 107285. Date of Electronic Publication: 2024 Jun 26. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8907422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1186 (Electronic) Linking ISSN: 10436618 NLM ISO Abbreviation: Pharmacol Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oct. 2015- : Amsterdam ; Elsevier Original Publication: London ; San Diego : Academic Press, c1989- |
| مواضيع طبية MeSH: | Heart Failure*/blood , Heart Failure*/diagnosis , Heart Failure*/physiopathology , Biomarkers*/blood , Matrix Metalloproteinase 9*/blood , Ventricular Remodeling*, Humans ; Animals |
| مستخلص: | Heart failure (HF) is the leading cause of morbidity and mortality in cardiovascular diseases, being responsible for many hospitalizations annually. HF is considered a public health problem with significant economic and social impact, which makes searches essential for strategies that improve the ability to predict and diagnose HF. In this way, biomarkers can help in risk stratification for a more personalized approach to patients with HF. Preclinical and clinical evidence shows the participation of matrix metalloproteinase 9 (MMP-9) in the HF process. In this review, we will demonstrate the critical role that MMP-9 plays in cardiac remodeling and dysfunction. We will also show its importance as a blood biomarker in acute and chronic HF patients. Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest. (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Extracellular matrix; Fibrosis; Inflammation; MMP-9; Systolic and diastolic dysfunction |
| المشرفين على المادة: | 0 (Biomarkers) EC 3.4.24.35 (Matrix Metalloproteinase 9) |
| تواريخ الأحداث: | Date Created: 20240628 Date Completed: 20240722 Latest Revision: 20240821 |
| رمز التحديث: | 20240821 |
| DOI: | 10.1016/j.phrs.2024.107285 |
| PMID: | 38942342 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1096-1186 |
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| DOI: | 10.1016/j.phrs.2024.107285 |